{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:16:21Z","timestamp":1789820181088,"version":"4.0.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"DOI":"10.1093\/ehjcvp\/pvx020","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T11:09:21Z","timestamp":1497352161000},"page":"54-63","source":"Crossref","is-referenced-by-count":41,"title":["Loop diuretics for chronic heart failure: a foe in disguise of a friend?"],"prefix":"10.1093","volume":"4","author":[{"given":"Chris J","family":"Kapelios","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Malliaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Kaldara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Vakrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N","family":"Nanas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"key\n\t\t\t\t20180105045352_pvx020-B1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.cardfail.2010.04.004","article-title":"HFSA 2010 comprehensive heart failure practice guideline","volume":"16","author":"Heart Failure Society of America","year":"2010","journal-title":"J Card Fail"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"18","author":"Authors\/Task Force Members; Document Reviewers","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B3","first-page":"CD003838","article-title":"Diuretics for heart failure","volume":"2","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B4","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/ejhf.619","article-title":"Dosing of loop diuretics in chronic heart failure: it\u2019s time for evidence","volume":"18","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/eurheartj\/ehi696","article-title":"Incidence of renal dysfunction over 6\u2009months in patients with chronic heart failure due to left ventricular systolic dysfunction: contributing factors and relationship to prognosis","volume":"27","year":"2006","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B6","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cardfail.2010.01.001","article-title":"Renal function in outpatients with chronic heart failure","volume":"16","year":"2010","journal-title":"J Card Fail"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B7","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/ejhf.462","article-title":"Loop diuretics, renal function and clinical outcome in patients with heart failure and reduced ejection fraction","volume":"18","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B8","first-page":"154","article-title":"High furosemide dose has detrimental effects on survival of patients with stable heart failure","volume":"56","year":"2015","journal-title":"Hellenic J Cardiol"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B9","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/CIRCHEARTFAILURE.113.000553","article-title":"Incidence and predictors of end-stage renal disease in outpatients with systolic heart failure","volume":"6","year":"2013","journal-title":"Circ Heart Fail"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ahj.2011.12.003","article-title":"Incidence, clinical predictors, and prognostic impact of worsening renal function in elderly patients with chronic heart failure on intensive medical therapy","volume":"163","author":"TIME-CHF Investigators","year":"2012","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ejhf.210","article-title":"Impact of worsening renal function related to medication in heart failure","volume":"17","author":"TIME\u2010CHF investigators","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/ehjcvp\/pvw016","article-title":"Mineralocorticoid receptor antagonists in patients with heart failure: current experience and future perspectives","volume":"3","year":"2017","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/ehjcvp\/pvv026","article-title":"Short-term mortality risk of serum potassium levels in acute heart failure following myocardial infarction","volume":"1","year":"2015","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B14","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.ejheart.2004.09.006","article-title":"Clinical and neurohumoral consequences of diuretic withdrawal in patients with chronic, stabilized heart failure and systolic dysfunction","volume":"7","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B15","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.jacc.2010.10.065","article-title":"Volume status and diuretic therapy in systolic heart failure and the detection of early abnormalities in renal and tubular function","volume":"57","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B16","first-page":"CD008966","article-title":"B-type natriuretic peptide-guided treatment for heart failure","volume":"12","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B17","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jchf.2014.05.014","article-title":"The effects of dose reduction of furosemide on glomerular filtration rate in stable systolic heart failure","volume":"2","year":"2014","journal-title":"JACC Heart Fail"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B18","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.ijcard.2014.09.156","article-title":"Lowering furosemide dose in stable chronic heart failure patients with reduced ejection fraction is not accompanied by decompensation: a randomized study","volume":"177","year":"2014","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B19","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1161\/01.CIR.100.12.1311","article-title":"Diuretics and risk of arrhythmic death in patients with left ventricular dysfunction","volume":"100","year":"1999","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B20","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0735-1097(03)00765-4","article-title":"Diuretic use, progressive heart failure, and death in patients in the Studies Of Left Ventricular Dysfunction (SOLVD)","volume":"42","author":"Studies of Left Ventricular Dysfunction","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B21","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cardfail.2006.03.006","article-title":"Diuretic use, progressive heart failure, and death in patients in the DIG study","volume":"12","year":"2006","journal-title":"J Card Fail"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B22","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/eurheartj\/ehi890","article-title":"Heart failure, chronic diuretic use, and increase in mortality and hospitalization: an observational study using propensity score methods","volume":"27","year":"2006","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B23","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ijcard.2007.05.032","article-title":"A propensity-matched study of the effects of chronic diuretic therapy on mortality and hospitalization in older adults with heart failure","volume":"125","year":"2008","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B24","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1253\/circj.CJ-11-1196","article-title":"Loop diuretic use at discharge is associated with adverse outcomes in hospitalized patients with heart failure: a report from the Japanese cardiac registry of heart failure in cardiology (JCARE-CARD)","volume":"76","author":"JCARE-CARD Investigators","year":"2012","journal-title":"Circ J"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B25","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1253\/circj.CJ-16-0216","article-title":"Prognostic impact of loop diuretics in patients with chronic heart failure\u2014effects of addition of renin-angiotensin-aldosterone system inhibitors and \u03b2-Blockers","volume":"80","author":"CHART-2 Investigators","year":"2016","journal-title":"Circ J"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1067\/mhj.2002.123144","article-title":"Diuretic resistance predicts mortality in patients with advanced heart failure","volume":"144","author":"PRAISE Investigators. Prospective Randomized Amlodipine Survival Evaluation","year":"2002","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B27","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.amjcard.2005.12.072","article-title":"Relation of loop diuretic dose to mortality in advanced heart failure","volume":"97","year":"2006","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B28","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.cardfail.2008.01.015","article-title":"The association between high-dose diuretics and clinical stability in ambulatory chronic heart failure patients","volume":"14","year":"2008","journal-title":"J Card Fail"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B29","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ahj.2010.05.032","article-title":"Diuretic dose and long-term outcomes in elderly patients with heart failure after hospitalization","volume":"160","year":"2010","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/1074248410388807","article-title":"Prognostic implications of diuretic dose in chronic heart failure","volume":"16","year":"2011","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B31","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jacc.2011.01.052","article-title":"Interaction between loop diuretic-associated mortality and blood urea nitrogen concentration in chronic heart failure","volume":"58","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B32","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1751-7133.2011.00252.x","article-title":"Association of furosemide dose with clinical status, left ventricular dysfunction, natriuretic peptides, and outcome in clinically stable patients with chronic systolic heart failure","volume":"18","year":"2012","journal-title":"Congest Heart Fail"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B33","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/ijcp.12144","article-title":"Effects on survival of loop diuretic dosing in ambulatory patients with chronic heart failure using a propensity score analysis","volume":"67","year":"2013","journal-title":"Int J Clin Pract"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B34","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/eurheartj\/eht514","article-title":"Treatment with higher dosages of heart failure medication is associated with improved outcome following cardiac resynchronization therapy","volume":"35","year":"2014","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B35","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1136\/heartjnl-2013-305294","article-title":"Prospective development and validation of a model to predict heart failure hospitalisation","volume":"100","year":"2014","journal-title":"Heart"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B36","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s11936-009-0045-1","article-title":"How to use diuretics in heart failure","volume":"11","year":"2009","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"key\n\t\t\t\t20180105045352_pvx020-B37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jamda.2013.02.002","article-title":"Morbus diureticus in the elderly: epidemic overuse of a widely applied group of drugs","volume":"14","year":"2013","journal-title":"J Am Med Dir Assoc"}],"container-title":["European Heart Journal - Cardiovascular Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjcvp\/article-pdf\/4\/1\/54\/23029158\/pvx020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T09:54:06Z","timestamp":1515146046000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/ehjcvp\/article\/4\/1\/54\/3870393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,19]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,6,19]]},"published-print":{"date-parts":[[2018,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcvp\/pvx020","relation":{},"ISSN":["2055-6837","2055-6845"],"issn-type":[{"value":"2055-6837","type":"print"},{"value":"2055-6845","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,1]]},"published":{"date-parts":[[2017,6,19]]}}}