{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:46:14Z","timestamp":1780609574632,"version":"3.54.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim of the present study was to establish the safety and efficacy profile of prasugrel and ticagrelor in real-life acute coronary syndrome (ACS) patients with renal dysfunction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>All consecutive patients from RENAMI (REgistry of New Antiplatelets in patients with Myocardial Infarction) and BLEEMACS (Bleeding complications in a Multicenter registry of patients discharged with diagnosis of Acute Coronary Syndrome) registries were stratified according to estimated glomerular filtration rate (eGFR) lower or greater than 60\u2009mL\/min\/1.73\u2009m2. Death and myocardial infarction (MI) were the primary efficacy endpoints. Major bleedings (MBs), defined as Bleeding Academic Research Consortium bleeding types 3 to 5, constituted the safety endpoint. A total of 19\u00a0255 patients were enrolled. Mean age was 63\u2009\u00b1\u200912; 14\u00a0892 (77.3%) were males. A total of 2490 (12.9%) patients had chronic kidney disease (CKD), defined as eGFR &amp;lt;60\u2009mL\/min\/1.73\u2009m2. Mean follow-up was 13\u2009\u00b1\u20095\u2009months. Mortality was significantly higher in CKD patients (9.4% vs. 2.6%, P\u2009&amp;lt;\u20090.0001), as well as the incidence of reinfarction (5.8% vs. 2.9%, P\u2009&amp;lt;\u20090.0001) and MB (5.7% vs. 3%, P\u2009&amp;lt;\u20090.0001). At Cox multivariable analysis, potent P2Y12 inhibitors significantly reduced the mortality rate [hazard ratio (HR) 0.82, 95% confidence interval (CI) 0.54\u20130.96; P\u2009=\u20090.006] and the risk of reinfarction (HR 0.53, 95% CI 0.30\u20130.95; P\u2009=\u20090.033) in CKD patients as compared to clopidogrel. The reduction of risk of reinfarction was confirmed in patients with preserved renal function. Potent P2Y12 inhibitors did not increase the risk of MB in CKD patients (HR 1.00, 95% CI 0.59\u20131.68; P\u2009=\u20090.985).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In ACS patients with CKD, prasugrel and ticagrelor are associated with lower risk of death and recurrent MI without increasing the risk of MB.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcvp\/pvz048","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T07:48:01Z","timestamp":1568015281000},"page":"31-42","source":"Crossref","is-referenced-by-count":53,"title":["P2Y12 inhibitors in acute coronary syndrome patients with renal dysfunction: an analysis from the RENAMI and BleeMACS projects"],"prefix":"10.1093","volume":"6","author":[{"given":"Ovidio","family":"De Filippo","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medical Sciences, AOU Citt\u00e0 della Salute e della Scienza, University of Turin, Corso Bramante 88\/90, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"D\u2019Ascenzo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medical Sciences, AOU Citt\u00e0 della Salute e della Scienza, University of Turin, Corso Bramante 88\/90, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Raposeiras-Roubin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Alvaro Cunqueiro, Estrada de Clara Campoamor, 341, Vigo, Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Abu-Assi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Alvaro Cunqueiro, Estrada de Clara Campoamor, 341, Vigo, Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Peyracchia","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medical Sciences, AOU Citt\u00e0 della Salute e della Scienza, University of Turin, Corso Bramante 88\/90, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7868-1852","authenticated-orcid":false,"given":"Pier Paolo","family":"Bocchino","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medical Sciences, AOU Citt\u00e0 della Salute e della Scienza, University of Turin, Corso Bramante 88\/90, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Kinnaird","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital of Wales, Heath Park Way, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Ariza-Sol\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital de Bellvitge, Av. Mare de D\u00e9u de Bellvitge, 3, 08907 L'Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Liebetrau","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kerckhoff Heart and Thorax Center, Benekestr. 2-8 61231, Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Manzano-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Virgen Arrtixaca, Ctra. Madrid-Cartagena, s\/n, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Boccuzzi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, S.G. Bosco Hospital, Piazza del Donatore di Sangue, 3, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Paulo Simao","family":"Henriques","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Templin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B","family":"Wilton","sequence":"additional","affiliation":[{"name":"Libin Cardiovascular Institute of Alberta, GE64 3280 Hospital Drive NW, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Omed\u00e8","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medical Sciences, AOU Citt\u00e0 della Salute e della Scienza, University of Turin, Corso Bramante 88\/90, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazar","family":"Velicki","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, and Institute of Cardiovascular Diseases Vojvodina, Put doktora Goldmana 4, 21204 Sremska Kamenica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Xanthopoulou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Patras University Hospital, Rion, 265 04 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Correia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital S\u00e3o Rafael - Avenida S\u00e3o Rafael, 2152 - S\u00e3o Marcos, 41253-196 Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Cerrato","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Orbassano, and San Luigi Gonzaga University Hospital, Regione Gonzole, 10, 10043 Orbassano Rivoli, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rognoni","sequence":"additional","affiliation":[{"name":"Coronary Care Unit and Catheterization Laboratory, A.O.U. Maggiore della Carit\u00e0, Corso Mazzini 18, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo","family":"Fabrizio","sequence":"additional","affiliation":[{"name":"Department of Cardiology, S.G. Bosco Hospital, Piazza del Donatore di Sangue, 3, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Nu\u00f1ez-Gil","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Cardiovascular Institute, Hospital Cl\u00ednico Universitario San Carlos, Calle del Prof Mart\u00edn Lagos, s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Iannaccone","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cSS. Annunziata\u201d Hospital, Via Ospedali, 9, Savigliano, Cuneo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Montabone","sequence":"additional","affiliation":[{"name":"Department of Cardiology, S.G. Bosco Hospital, Piazza del Donatore di Sangue, 3, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Assiut University, Libraries Street, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Fujii","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Durante","sequence":"additional","affiliation":[{"name":"U.O. Cardiologia, Ospedale Valduce, Via Dante Alighieri, 11, 22100 Como, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiantao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Gili","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Magnani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Varbella","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Orbassano, and San Luigi Gonzaga University Hospital, Regione Gonzole, 10, 10043 Orbassano Rivoli, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuma","family":"Kawaji","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mitsubishi Kyoto Hospital, 1 Katsura Gosho-cho, Nishikyo-ku, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Flores","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Virgen Arrtixaca, Ctra. Madrid-Cartagena, s\/n, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Garay","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital de Bellvitge, Av. 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