{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:13:43Z","timestamp":1784754823592,"version":"3.55.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG10\/71\/28462"],"award-info":[{"award-number":["PG10\/71\/28462"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome-ISSF","award":["204809\/Z\/16\/Z"],"award-info":[{"award-number":["204809\/Z\/16\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Vitamin D deficiency is associated with cardiovascular events in chronic kidney disease (CKD) yet the impact of supplementation is controversial. Previous active vitamin D supplementation studies did not show improvement in cardiac structure or function but the effect of native vitamin D supplementation in CKD patients with low vitamin D levels is unknown. We have addressed this question via both a randomized double-blind prospective study and a meta-analysis of three randomized placebo-controlled studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We conducted a randomized double-blind, placebo-controlled trial of vitamin D supplementation in stable, non-diabetic, CKD three to four patients with circulating vitamin D &amp;lt;75nmol\/L, who were receiving treatment with ACEi or ARB and had high-normal left ventricular (LV) mass. Patients were randomized to receive six directly observed doses of 100\u00a0000\u2009IU cholecalciferol (n\u2009=\u200925) or matched placebo (n\u2009=\u200923). The primary endpoint was changed in LV mass index (LVMI) over 52\u2009weeks, as assessed by cardiac magnetic resonance imaging. Secondary endpoints included changes in LV ejection fraction (LVEF); LV and right ventricular volumes and left and right atrial area. Vitamin D concentration increased with the administration of cholecalciferol. The change in LVMI with cholecalciferol [median (inter-quartile range), \u22120.25\u2009g (\u22127.20 to 5.30)] was no different from placebo [\u22124.30\u2009g (9.70 to 2.60)]. There was no difference in changes of LVEF; LV and right ventricular volumes and left and right atrial area. The meta-analysis of three 52-week, randomized placebo-controlled studies using active\/native vitamin D supplementation showed no differences in LVMI measurements.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Vitamin D supplementation does not have beneficial effects on LV mass in CKD patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcvp\/pvz080","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T12:08:19Z","timestamp":1575893299000},"page":"302-311","source":"Crossref","is-referenced-by-count":18,"title":["Impact of vitamin D on cardiac structure and function in chronic kidney disease patients with hypovitaminosis D: a randomized controlled trial and meta-analysis"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6863-2325","authenticated-orcid":false,"given":"Debasish","family":"Banerjee","sequence":"first","affiliation":[{"name":"Renal and Transplantation Unit, St George\u2019s University Hospital NHS Foundation Trust, G 2.113, Grosvenor Wing, Blackshaw Road, Tooting, London SW17 0QT, UK"},{"name":"Cardiology Clinical Academic Group, Molecular and Clinical Sciences Research Centre, St George\u2019s University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihil","family":"Chitalia","sequence":"additional","affiliation":[{"name":"Cardiology Clinical Academic Group, Molecular and Clinical Sciences Research Centre, St George\u2019s University of London, London, UK"},{"name":"Renal Medicine, Darent Valley Hospital, Dartford, Kent, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina Chis","family":"Ster","sequence":"additional","affiliation":[{"name":"Institute of Infection and Immunity, St George's University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Appelbaum","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Centre, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Thadhani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA"},{"name":"Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Kaski","sequence":"additional","affiliation":[{"name":"Cardiology Clinical Academic Group, Molecular and Clinical Sciences Research Centre, St George\u2019s University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goldsmith","sequence":"additional","affiliation":[{"name":"Cardiology Clinical Academic Group, Molecular and Clinical Sciences Research Centre, St George\u2019s University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"key":"2021072618110596000_pvz080-B1","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1161\/01.HYP.0000102971.85504.7c","article-title":"American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. 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