{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:11:32Z","timestamp":1789503092409,"version":"build-2803163510"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"publisher","award":["628.011.214"],"award-info":[{"award-number":["628.011.214"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Invasive haemodynamic monitoring of heart failure (HF) is used to detect deterioration in an early phase thereby preventing hospitalizations. However, this invasive approach is costly and presently lacks widespread accessibility. Hence, there is a pressing need to identify an alternative non-invasive method that is reliable and more readily available. In this pilot study, we investigated the relation between wrist-derived photoplethysmography (PPG) signals and the invasively measured pulmonary capillary wedge pressure (PCWP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Fourteen patients with aortic valve stenosis who underwent transcatheter aortic valve replacement with concomitant right heart catheterization and PPG measurements were included. Six unique features of the PPG signals [heart rate, heart rate variability, systolic amplitude (SA), diastolic amplitude, crest time (CT), and large artery stiffness index (LASI)] were extracted. These features were used to estimate the continuous PCWP values and the categorized PCWP (low &amp;lt; 12\u2005mmHg vs. high \u2265 12\u2005mmHg). All PPG features resulted in regression models that showed low correlations with the invasively measured PCWP. Classification models resulted in higher performances: the model based on the SA and the model based on the LASI both resulted in an area under the curve (AUC) of 0.86 and the model based on the CT resulted in an AUC of 0.72.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These results demonstrate the capability to non-invasively classify patients into clinically meaningful categories of PCWP using PPG signals from a wrist-worn wearable device. To enhance and fully explore its potential, the relationship between PPG and PCWP should be further investigated in a larger cohort of HF patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjdh\/ztae020","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T17:44:52Z","timestamp":1709833492000},"page":"379-383","source":"Crossref","is-referenced-by-count":4,"title":["Photoplethysmography and intracardiac pressures: early insights from a pilot study"],"prefix":"10.1093","volume":"5","author":[{"given":"Niels T B","family":"Scholte","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center , Dr. Molewaterplein 40, 3015 GD, Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemiek E","family":"van Ravensberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center , Dr. Molewaterplein 40, 3015 GD, Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roos","family":"Edgar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Center , Nijmegen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2449-8504","authenticated-orcid":false,"given":"Antoon J M","family":"van den Enden","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center , Dr. Molewaterplein 40, 3015 GD, Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas M D A","family":"van Mieghem","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center , Dr. Molewaterplein 40, 3015 GD, Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper J","family":"Brugts","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center , Dr. Molewaterplein 40, 3015 GD, Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-7805","authenticated-orcid":false,"given":"Judith L","family":"Bonnes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Center , Nijmegen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0272-5617","authenticated-orcid":false,"given":"Nico","family":"Bruining","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center , Dr. Molewaterplein 40, 3015 GD, Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6340-2590","authenticated-orcid":false,"given":"Robert M A","family":"van der Boon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center , Dr. Molewaterplein 40, 3015 GD, Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"2024052015212716100_ztae020-B1","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: a comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2023","journal-title":"Cardiovasc Res"},{"key":"2024052015212716100_ztae020-B2","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1093\/eurheartj\/ehad280","article-title":"Telemonitoring for heart failure: a 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How to handle the problems of zero leveling and respiratory swings","volume":"190","author":"Kovacs","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2024052015212716100_ztae020-B7","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jacbts.2023.02.001","article-title":"A novel multisensor device for absolute intracardiac pressure measurement, detection, and management of heart failure","volume":"8","author":"Mace","year":"2023","journal-title":"JACC Basic Transl Sci"},{"key":"2024052015212716100_ztae020-B8","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1016\/j.jacc.2017.04.043","article-title":"Hospitalization for recently diagnosed versus worsening chronic heart failure: from the ASCEND-HF trial","volume":"69","author":"Greene","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2024052015212716100_ztae020-B9","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.amjcard.2016.11.063","article-title":"Usefulness of a noninvasive device to identify elevated left ventricular filling pressure using finger photoplethysmography during a valsalva maneuver","volume":"119","author":"Galiatsatos","year":"2017","journal-title":"Am J Cardiol"},{"key":"2024052015212716100_ztae020-B10","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.amjcard.2017.06.029","article-title":"Usefulness of pulse amplitude changes during the valsalva maneuver measured using finger photoplethysmography to identify elevated pulmonary capillary wedge pressure in patients with heart failure","volume":"120","author":"Gilotra","year":"2017","journal-title":"Am J Cardiol"},{"key":"2024052015212716100_ztae020-B11","doi-asserted-by":"crossref","first-page":"e003676","DOI":"10.1161\/CIRCGEN.121.003676","article-title":"Machine learning to understand genetic and clinical factors associated with the pulse waveform dicrotic notch","volume":"16","author":"Cunningham","year":"2023","journal-title":"Circ Genom Precis Med"}],"container-title":["European Heart Journal - Digital Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjdh\/advance-article-pdf\/doi\/10.1093\/ehjdh\/ztae020\/57011272\/ztae020.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjdh\/article-pdf\/5\/3\/379\/57764999\/ztae020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjdh\/article-pdf\/5\/3\/379\/57764999\/ztae020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T15:21:41Z","timestamp":1716218501000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjdh\/article\/5\/3\/379\/7623698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,7]]},"published-print":{"date-parts":[[2024,5,20]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjdh\/ztae020","relation":{},"ISSN":["2634-3916"],"issn-type":[{"value":"2634-3916","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,3,7]]}}}