{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:58:48Z","timestamp":1769727528685,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016242","name":"Boston Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016242","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Investigator-Sponsored Research Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>HeartLogic, an algorithm in implanted devices, predicts heart failure (HF) episodes via a remotely monitored index, aiding proactive congestion treatment to prevent acute decompensation. This study assessed the efficacy and safety of pre-emptive HF management using the HeartLogic index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The HeartLogic France Cohort Study is a prospective multicentre investigation involving 310 HF patients with implanted cardioverter defibrillators enrolled from 10 French centres. The HeartLogic\u2122 index was monitored for 12 months, and when the index reached \u226516, patients were contacted to adjust HF treatment. The primary endpoint was unscheduled hospitalization for HF. An independent blinded committee adjudicated the events. A total of 309 patients (65 \u00b1 10 years old; 83.5% male, left ventricular ejection fraction 31 \u00b1 9%) were included in the analysis. Ischemic cardiomyopathy was present in 61.2% (n = 189) of the patients, and 52.8% (n = 163) had a cardiac resynchronization therapy device. During follow-up, 406 alerts occurred in 158 patients (1.33 alerts\/patient-year), resulting in treatment modification in 39.6% of alerts. A total of 24 unplanned HF hospitalizations occurred in 19 (6.1%) patients. Sixteen (66.7%) of those hospitalizations were preceded by a HeartLogic alert, of which 14 (87.5%) triggered a drug modification before hospitalization. Eighteen deaths (5.8%) occurred, including 10 due to cardiovascular causes. An increase in creatinine \u226530% and symptomatic hypotension were reported in two patients. Hyperkalemia and hyponatremia were not observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pre-emptive HF management guided by the HeartLogic index was associated with low rates of unplanned hospitalizations and adverse events over a 12-month follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov, ID: NCT04619888.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjdh\/ztaf133","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:06:31Z","timestamp":1762952791000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact and safety of remote monitoring of heart failure patients managed with the HeartLogic algorithm: the HeartLogic France Cohort Study"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9350-2437","authenticated-orcid":false,"given":"Rodrigue","family":"Garcia","sequence":"first","affiliation":[{"name":"Cardiology Department, University Hospital of Poitiers , 2 rue de la Mil\u00e9trie, Poitiers F-86021 ,","place":["France"]},{"name":"Centre D'Investigation Clinique 1402, University Hospital of Poitiers , 2 rue de la Mil\u00e9trie, Poitiers F-86021 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7980-6036","authenticated-orcid":false,"given":"Daniel","family":"Gras","sequence":"additional","affiliation":[{"name":"Cardiology Department, H\u00f4pital Priv\u00e9 du Confluent , 2-4 Rue \u00c9ric Tabarly, Nantes 44000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6697-7194","authenticated-orcid":false,"given":"Jacques","family":"Mansourati","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital of Brest , Boulevard Tanguy Prigent, Brest 29200 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7183-4278","authenticated-orcid":false,"given":"Pascal","family":"Defaye","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Grenoble Alpes , Avenue des Maquis du Gr\u00e9sivaudan, Grenoble 38043 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3449-1800","authenticated-orcid":false,"given":"Arnaud","family":"Bisson","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital of Tours , Avenue de la R\u00e9publique, Chambray-l\u00e8s-Tours 37170 ,","place":["France"]},{"name":"Cardiology Department, University Hospital of Orl\u00e9ans , 14 Avenue de l'H\u00f4pital, Orl\u00e9ans 45100 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1280-7042","authenticated-orcid":false,"given":"Serge","family":"Boveda","sequence":"additional","affiliation":[{"name":"Cardiology Department, Clinique Pasteur , 45 Avenue de Lombez, Toulouse 31076 ,","place":["France"]},{"name":"Universiteit Ziekenhuis, Vrije Universiteit Brussel (VUB) , Laarbeeklaan 101, Jette Brussels 1090 ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5942-9964","authenticated-orcid":false,"given":"Lisa","family":"Durocher","sequence":"additional","affiliation":[{"name":"Centre D'Investigation Clinique 1402, University Hospital of Poitiers , 2 rue de la Mil\u00e9trie, Poitiers F-86021 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