{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:21:19Z","timestamp":1792794079459,"version":"4.5.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000851","name":"Queen Mary, University of London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000851","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UKRI Future Leaders Fellowship","award":["MR\/W004720\/1"],"award-info":[{"award-number":["MR\/W004720\/1"]}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["101083771"],"award-info":[{"award-number":["101083771"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health Research Barts Biomedical Research Centre","award":["NIHR203330"],"award-info":[{"award-number":["NIHR203330"]}],"id":[{"id":"https:\/\/ror.org\/0187kwz08","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As transcatheter aortic valve implantation (TAVI) expands to younger populations, durability has become a concern, requiring a lifetime rather than a single-procedure perspective. While clinical trials suggest comparable mid-term performance to surgical bioprostheses, data beyond 10 years remain limited, particularly for bicuspid valves, valve-in-valve procedures, and complex anatomies. Computational modelling combines patient anatomy and device design in computer-based simulations to study valve performance under physiological loading. Applied to TAVI, these models can reproduce implantation, evaluate mechanical stresses, and simulate blood flow, providing mechanistic insights into deterioration processes, including altered leaflet loading, stent deformation, and thrombosis-prone flow. Although these simulations do not directly assess durability, they use surrogate metrics linked with these mechanisms, helping identify factors that may influence longevity and guide design and procedural refinements. Clinically, modelling could support patient-specific planning and reintervention strategies, informing decisions across the valve-replacement pathway, an important consideration as younger patients are likely to undergo multiple lifetime procedures. Integrating these tools into pre-procedural planning may help anticipate challenges such as coronary access, annular geometry, and redo feasibility. However, current studies report elements of verification and field-level validation, but none complete a pre-specified, calibrated surrogate-to-outcome validation with uncertainty\/sensitivity analysis; thus, durability predictions remain exploratory. Progress needs transparent verification, field checks vs. bench or imaging, surrogate calibration to data, outcome testing in independent cohorts, and routine uncertainty\/sensitivity reporting, with close clinician-engineer collaboration. This review underscores the need for a multidisciplinary approach and provides a critical analysis of the available tools and their potential to advance long-term outcomes.<\/jats:p>","DOI":"10.1093\/ehjdh\/ztag020","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T12:37:32Z","timestamp":1769863052000},"source":"Crossref","is-referenced-by-count":7,"title":["Understanding the mechanisms of TAVI durability through computational modelling: a multidisciplinary review"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7009-3447","authenticated-orcid":false,"given":"Elisa","family":"Rauseo","sequence":"first","affiliation":[{"name":"William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]},{"name":"Barts Heart Centre, Barts Health NHS Trust , W. Smithfield, London EC1A 7BE ,","place":["UK"]},{"name":"Digital Environment Research Institute, Queen Mary University of London , 67-75 New Rd, London E1 1HH ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bevis","sequence":"additional","affiliation":[{"name":"Digital Environment Research Institute, Queen Mary University of London , 67-75 New Rd, London E1 1HH ,","place":["UK"]},{"name":"School of Engineering and Materials Science, Queen Mary University of London , Mile End Road, London E1 4NS ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"Digital Environment Research Institute, Queen Mary University of London , 67-75 New Rd, London E1 1HH ,","place":["UK"]},{"name":"Department of Medicine, University of Cambridge , Cambridge ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen E","family":"Petersen","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]},{"name":"Barts Heart Centre, Barts Health NHS Trust , W. Smithfield, London EC1A 7BE ,","place":["UK"]},{"name":"NIHR Barts Biomedical Research Centre, Queen Mary University of London , Charterhouse Square, London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7941-9653","authenticated-orcid":false,"given":"Anthony","family":"Mathur","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, Barts Health NHS Trust , W. Smithfield, London EC1A 7BE ,","place":["UK"]},{"name":"NIHR Barts Biomedical Research Centre, Queen Mary University of London , Charterhouse Square, London ,","place":["UK"]},{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory G","family":"Slabaugh","sequence":"additional","affiliation":[{"name":"Digital Environment Research Institute, Queen Mary University of London , 67-75 New Rd, London E1 1HH ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-0928","authenticated-orcid":false,"given":"Caroline H","family":"Roney","sequence":"additional","affiliation":[{"name":"Digital Environment Research Institute, Queen Mary University of London , 67-75 New Rd, London E1 1HH ,","place":["UK"]},{"name":"School of Engineering and Materials Science, Queen Mary University of London , Mile End Road, London E1 4NS ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"2026021723264285400_ztag020-B1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur Heart J"},{"key":"2026021723264285400_ztag020-B2","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jacc.2020.11.035","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Writing Committee Members","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2026021723264285400_ztag020-B3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.amjcard.2024.08.014","article-title":"Long-term results following transcatheter versus surgical aortic valve replacement in low-risk patients with severe aortic stenosis: a systematic review and meta-analysis of randomized trials","volume":"230","author":"Caminiti","year":"2024","journal-title":"Am J Cardiol"},{"key":"2026021723264285400_ztag020-B4","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1161\/CIRCULATIONAHA.118.036606","article-title":"Five-year clinical and echocardiographic outcomes from the NOTION randomized clinical trial in patients at lower surgical risk","volume":"139","author":"Thyregod","year":"2019","journal-title":"Circulation"},{"key":"2026021723264285400_ztag020-B5","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1093\/eurheartj\/ehae043","article-title":"Transcatheter or surgical aortic valve implantation: 10-year outcomes of the NOTION trial","volume":"45","author":"H\u00f8rsted Thyregod","year":"2024","journal-title":"Eur Heart J"},{"key":"2026021723264285400_ztag020-B6","doi-asserted-by":"crossref","first-page":"102478","DOI":"10.1016\/j.cpcardiol.2024.102478","article-title":"Complications in transcatheter aortic valve replacement: a comprehensive analysis and management strategies","volume":"49","author":"Zou","year":"2024","journal-title":"Curr Probl Cardiol"},{"key":"2026021723264285400_ztag020-B7","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/S0140-6736(17)30757-2","article-title":"Subclinical leaflet thrombosis in surgical and transcatheter bioprosthetic aortic valves: an observational study","volume":"389","author":"Chakravarty","year":"2017","journal-title":"Lancet"},{"key":"2026021723264285400_ztag020-B8","doi-asserted-by":"crossref","first-page":"S3629","DOI":"10.21037\/jtd.2018.07.38","article-title":"Valve durability after transcatheter aortic valve implantation","volume":"10","author":"Kataruka","year":"2018","journal-title":"J Thorac Dis"},{"key":"2026021723264285400_ztag020-B9","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.3390\/jcm12175645","article-title":"TAVI after more than 20 years","volume":"12","author":"Postolache","year":"2023","journal-title":"J Clin Med"},{"key":"2026021723264285400_ztag020-B10","doi-asserted-by":"crossref","first-page":"100032","DOI":"10.1016\/j.shj.2022.100032","article-title":"Biomechanics of transcatheter aortic valve replacement complications and computational predictive modeling","volume":"6","author":"Esmailie","year":"2022","journal-title":"Struct Heart"},{"key":"2026021723264285400_ztag020-B11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/14779072.2021.1850265","article-title":"In silico approaches for transcatheter aortic valve replacement inspection","volume":"19","author":"Luraghi","year":"2021","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"2026021723264285400_ztag020-B12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijcard.2016.01.138","article-title":"Mathematics and transcatheter aortic valve implantation: use of computational fluid dynamics and finite element analysis. Is this the future?","volume":"207","author":"Zuin","year":"2016","journal-title":"Int J Cardiol"},{"key":"2026021723264285400_ztag020-B13","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.jacc.2021.02.038","article-title":"Valve academic research consortium 3: updated endpoint definitions for aortic valve clinical research","volume":"77","author":"G\u00e9n\u00e9reux","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2026021723264285400_ztag020-B14","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/CIRCULATIONAHA.117.030729","article-title":"Standardized definition of structural valve degeneration for surgical and transcatheter bioprosthetic aortic valves","volume":"137","author":"Dvir","year":"2018","journal-title":"Circulation"},{"key":"2026021723264285400_ztag020-B15","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1093\/eurheartj\/ehx303","article-title":"Standardized definitions of structural deterioration and valve failure in assessing long-term durability of transcatheter and surgical aortic bioprosthetic valves: a consensus statement from the European Association of Percutaneous Cardiovascular Interventions (EAPCI) endorsed by the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"38","author":"Capodanno","year":"2017","journal-title":"Eur Heart J"},{"key":"2026021723264285400_ztag020-B16","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.jtcvs.2008.05.054","article-title":"The sinus of valsalva relieves abnormal stress on aortic valve leaflets by facilitating smooth closure","volume":"136","author":"Katayama","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026021723264285400_ztag020-B17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/10255840500141486","article-title":"Finite element modelling and simulations in cardiovascular mechanics and cardiology: a bibliography 1993\u20132004","volume":"8","author":"Mackerle","year":"2005","journal-title":"Comput Methods Biomech Biomed Engin"},{"key":"2026021723264285400_ztag020-B18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/heartjnl-2015-308044","article-title":"Computational fluid dynamics modelling in cardiovascular medicine","volume":"102","author":"Morris","year":"2016","journal-title":"Heart"},{"key":"2026021723264285400_ztag020-B19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.medengphy.2020.01.008","article-title":"Fluid\u2013structure interaction modeling in cardiovascular medicine\u2014a systematic review 2017\u20132019","volume":"78","author":"Hirschhorn","year":"2020","journal-title":"Med Eng Phys"},{"key":"2026021723264285400_ztag020-B20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11517-024-03215-8","article-title":"Generation of a virtual cohort of TAVI patients for in silico trials: a statistical shape and machine learning analysis","volume":"63","author":"Scuoppo","year":"2024","journal-title":"Med Biol Eng Comput"},{"key":"2026021723264285400_ztag020-B21","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1016\/j.jbiomech.2015.07.031","article-title":"Comparison of transcatheter aortic valve and surgical bioprosthetic valve durability: a fatigue simulation study","volume":"48","author":"Martin","year":"2015","journal-title":"J Biomech"},{"key":"2026021723264285400_ztag020-B22","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3390\/bioengineering10020188","article-title":"Mild paravalvular leak may pose an increased thrombogenic risk in transcatheter aortic valve replacement (TAVR) patients-insights from patient specific in vitro and in silico studies","volume":"10","author":"Kovarovic","year":"2023","journal-title":"Bioengineering"},{"key":"2026021723264285400_ztag020-B23","first-page":"512","volume-title":"Current Directions in Biomedical Engineering","author":"Borowski","year":"2022"},{"key":"2026021723264285400_ztag020-B24","first-page":"927","article-title":"Valve thrombosis following transcatheter aortic valve replacement: significance of blood stasis on the leaflets","volume":"51","author":"Vahidkhah","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"2026021723264285400_ztag020-B25","doi-asserted-by":"crossref","first-page":"108517","DOI":"10.1016\/j.cmpb.2024.108517","article-title":"Computational hemodynamic indices to identify transcatheter aortic valve implantation degeneration","volume":"259","author":"Crugnola","year":"2025","journal-title":"Comput Methods Programs Biomed"},{"key":"2026021723264285400_ztag020-B26","doi-asserted-by":"crossref","first-page":"e3704","DOI":"10.1002\/cnm.3704","article-title":"Fluid\u2013structure interaction analysis of transcatheter aortic valve implantation","volume":"39","author":"Fumagalli","year":"2023","journal-title":"Int J Numer Method Biomed Eng"},{"key":"2026021723264285400_ztag020-B27","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s13239-021-00596-x","article-title":"Predictive model for thrombus formation after transcatheter valve replacement","volume":"12","author":"Hatoum","year":"2021","journal-title":"Cardiovasc Eng Technol"},{"key":"2026021723264285400_ztag020-B28","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1007\/s10439-020-02532-x","article-title":"Influence of patient-specific characteristics on transcatheter heart valve neo-sinus flow: an in silico study","volume":"48","author":"Singh-Gryzbon","year":"2020","journal-title":"Ann Biomed Eng"},{"key":"2026021723264285400_ztag020-B29","doi-asserted-by":"crossref","first-page":"100180","DOI":"10.1016\/j.shj.2023.100180","article-title":"Early detection of risk of neo-sinus blood stasis post-transcatheter aortic valve replacement using personalized hemodynamic analysis","volume":"7","author":"Khodaei","year":"2023","journal-title":"Struct Heart"},{"key":"2026021723264285400_ztag020-B30","doi-asserted-by":"crossref","first-page":"046120","DOI":"10.1063\/5.0170583","article-title":"Altered blood flow due to larger aortic diameters in patients with transcatheter heart valve thrombosis","volume":"7","author":"Jahren","year":"2023","journal-title":"APL Bioeng"},{"key":"2026021723264285400_ztag020-B31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/bioengineering8050052","article-title":"Corevalve vs. Sapien 3 transcatheter aortic valve replacement: a finite element analysis study","volume":"8","author":"Nappi","year":"2021","journal-title":"Bioengineering"},{"key":"2026021723264285400_ztag020-B32","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s10439-023-03419-3","article-title":"Effect of sinotubular junction size on TAVR leaflet thrombosis: a fluid\u2013structure interaction analysis","volume":"52","author":"Oks","year":"2024","journal-title":"Ann Biomed Eng"},{"key":"2026021723264285400_ztag020-B33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jbiomech.2016.12.031","article-title":"The impact of imperfect frame deployment and rotational orientation on stress within the prosthetic leaflets during transcatheter aortic valve implantation","volume":"53","author":"Bailey","year":"2017","journal-title":"J Biomech"},{"key":"2026021723264285400_ztag020-B34","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s10439-015-1429-x","article-title":"Fluid\u2013structure interaction model of a percutaneous aortic valve: comparison with an in vitro test and feasibility study in a patient-specific case","volume":"44","author":"Wu","year":"2016","journal-title":"Ann Biomed Eng"},{"key":"2026021723264285400_ztag020-B35","doi-asserted-by":"crossref","first-page":"110804","DOI":"10.1016\/j.jbiomech.2021.110804","article-title":"Force distribution within the frame of self-expanding transcatheter aortic valve: insights from in-vivo finite element analysis","volume":"128","author":"Xiong","year":"2021","journal-title":"J Biomech"},{"key":"2026021723264285400_ztag020-B36","doi-asserted-by":"crossref","first-page":"107886","DOI":"10.1016\/j.cmpb.2023.107886","article-title":"In silico fatigue optimization of TAVR stent designs with physiological motion in a beating heart model","volume":"243","author":"Baylous","year":"2024","journal-title":"Comput Methods Programs Biomed"},{"key":"2026021723264285400_ztag020-B37","first-page":"90","article-title":"Prosthetic valve monitoring via in situ pressure sensors","volume":"13","author":"Bailoor","year":"2022","journal-title":"In Silico Concept Evaluation using Supervised Learning. Cardiovasc Eng Technol"},{"key":"2026021723264285400_ztag020-B38","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s13239-022-00614-6","article-title":"Leaflet stresses during full device simulation of crimping to 6\u2005mm in transcatheter aortic valve implantation, TAVI","volume":"13","author":"Bressloff","year":"2022","journal-title":"Cardiovasc Eng Technol"},{"key":"2026021723264285400_ztag020-B39","doi-asserted-by":"crossref","first-page":"104745","DOI":"10.1016\/j.jmbbm.2021.104745","article-title":"Simulating the time evolving geometry, mechanical properties, and fibrous structure of bioprosthetic heart valve leaflets under cyclic loading","volume":"123","author":"Zhang","year":"2021","journal-title":"J Mech Behav Biomed Mater"},{"key":"2026021723264285400_ztag020-B40","doi-asserted-by":"crossref","first-page":"19007","DOI":"10.1073\/pnas.2002821117","article-title":"Thinner biological tissues induce leaflet flutter in aortic heart valve replacements","volume":"117","author":"Johnson","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026021723264285400_ztag020-B41","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1016\/j.jbiomech.2010.08.010","article-title":"Simulated elliptical bioprosthetic valve deformation: implications for asymmetric transcatheter valve deployment","volume":"43","author":"Sun","year":"2010","journal-title":"J Biomech"},{"key":"2026021723264285400_ztag020-B42","doi-asserted-by":"crossref","first-page":"108828","DOI":"10.1016\/j.compbiomed.2024.108828","article-title":"The relation between aortic morphology and transcatheter aortic heart valve thrombosis: particle tracing and platelet activation in larger aortic roots with and without neo-sinus","volume":"179","author":"Bornemann","year":"2024","journal-title":"Comput Biol Med"},{"key":"2026021723264285400_ztag020-B43","first-page":"499","volume-title":"Current Directions in Biomedical Engineering","author":"Borowski","year":"2023"},{"key":"2026021723264285400_ztag020-B44","doi-asserted-by":"crossref","first-page":"e3641","DOI":"10.1002\/cnm.3641","article-title":"Structural analysis of regional transcatheter aortic valve underexpansion and its implications for subclinical leaflet thrombosis","volume":"38","author":"Qiu","year":"2022","journal-title":"Int J Numer Method Biomed Eng"},{"key":"2026021723264285400_ztag020-B45","doi-asserted-by":"crossref","first-page":"e3649","DOI":"10.1002\/cnm.3649","article-title":"Fluid\u2013structure interaction analysis of eccentricity and leaflet rigidity on thrombosis biomarkers in bioprosthetic aortic valve replacements","volume":"38","author":"Oks","year":"2022","journal-title":"Int J Numer Method Biomed Eng"},{"key":"2026021723264285400_ztag020-B46","first-page":"418","article-title":"Aortic flow patterns after simulated implantation of transcatheter aortic valves","volume":"56","author":"Kopanidis","year":"2015","journal-title":"Hellenic J Cardiol"},{"key":"2026021723264285400_ztag020-B47","doi-asserted-by":"crossref","first-page":"201838","DOI":"10.1098\/rsos.201838","article-title":"Numerical models for assessing the risk of leaflet thrombosis post-transcatheter aortic valve-in-valve implantation: risk of leaflet thrombosis post ViV TAVI","volume":"7","author":"Mayo","year":"2020","journal-title":"R Soc Open Sci"},{"key":"2026021723264285400_ztag020-B48","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.athoracsur.2017.02.052","article-title":"Blood stasis on transcatheter valve leaflets and implications for valve-in-valve leaflet thrombosis","volume":"104","author":"Vahidkhah","year":"2017","journal-title":"Ann Thorac Surg"},{"key":"2026021723264285400_ztag020-B49","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jbiomech.2017.04.020","article-title":"Supra-annular valve-in-valve implantation reduces blood stasis on the transcatheter aortic valve leaflets","volume":"58","author":"Vahidkhah","year":"2017","journal-title":"J Biomech"},{"key":"2026021723264285400_ztag020-B50","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1080\/17434440.2018.1536427","article-title":"Principles of TAVR valve design, modelling, and testing","volume":"15","author":"Rotman","year":"2018","journal-title":"Expert Rev Med Devices"},{"key":"2026021723264285400_ztag020-B51","doi-asserted-by":"crossref","first-page":"804565","DOI":"10.3389\/fcvm.2021.804565","article-title":"Characterization of turbulent flow behind a transcatheter aortic valve in different implantation positions","volume":"8","author":"Pietrasanta","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"2026021723264285400_ztag020-B52","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jacc.2024.05.064","article-title":"Treatment of transcatheter aortic valve thrombosis: jacc review topic of the week","volume":"84","author":"Adrichem","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"2026021723264285400_ztag020-B53","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1016\/j.jacc.2020.04.043","article-title":"Subclinical leaflet thrombosis in transcatheter and surgical bioprosthetic valves: PARTNER 3 cardiac computed tomography substudy","volume":"75","author":"Makkar","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2026021723264285400_ztag020-B54","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.jacc.2017.02.051","article-title":"Bioprosthetic valve thrombosis","volume":"69","author":"Puri","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2026021723264285400_ztag020-B55","volume-title":"Assessing Credibility of Computational Modeling Through Verification and Validation: Application to Medical Devices","author":"ASME. V&V40\u20142018","year":"2018"},{"key":"2026021723264285400_ztag020-B56","doi-asserted-by":"crossref","first-page":"107727","DOI":"10.1016\/j.cmpb.2023.107727","article-title":"Credibility assessment of computational models according to ASME V&V40: application to the Bologna biomechanical computed tomography solution","volume":"240","author":"Aldieri","year":"2023","journal-title":"Comput Methods Programs Biomed"},{"key":"2026021723264285400_ztag020-B57","doi-asserted-by":"crossref","first-page":"e1012289","DOI":"10.1371\/journal.pcbi.1012289","article-title":"Credibility assessment of in silico clinical trials for medical devices","volume":"20","author":"Pathmanathan","year":"2024","journal-title":"PLoS Comput Biol"},{"key":"2026021723264285400_ztag020-B58","doi-asserted-by":"crossref","first-page":"15","DOI":"10.14797\/mdcvj.1201","article-title":"Transcatheter aortic valve implantation: long-term outcomes and durability","volume":"19","author":"Desai","year":"2023","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"2026021723264285400_ztag020-B59","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1161\/CIRCINTERVENTIONS.122.012388","article-title":"Lifetime management of aortic stenosis: transcatheter versus surgical treatment for young and low-risk patients","volume":"15","author":"Russo","year":"2022","journal-title":"Circ Cardiovasc Interv"},{"key":"2026021723264285400_ztag020-B60","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s13239-016-0285-7","article-title":"Fluid\u2013structure interaction study of transcatheter aortic valve dynamics using smoothed particle hydrodynamics","volume":"7","author":"Mao","year":"2016","journal-title":"Cardiovasc Eng Technol"},{"key":"2026021723264285400_ztag020-B61","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.3390\/jcm12144774","article-title":"Latest developments in adapting deep learning for assessing TAVR procedures and outcomes","volume":"12","author":"Tahir","year":"2023","journal-title":"J Clin Med"},{"key":"2026021723264285400_ztag020-B62","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3390\/bioengineering6040104","article-title":"A proof of concept study of using machine-learning in artificial aortic valve design: from leaflet design to stress analysis","volume":"6","author":"Liang","year":"2019","journal-title":"Bioengineering"},{"key":"2026021723264285400_ztag020-B63","unstructured":"EDITH consortium . EDITH CSA Deliverable 3.2: first draft of the VHT roadmap, 2023. 10.5281\/zenodo.8200955"}],"container-title":["European Heart Journal - Digital Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjdh\/advance-article-pdf\/doi\/10.1093\/ehjdh\/ztag020\/66712793\/ztag020.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjdh\/article-pdf\/7\/2\/ztag020\/66712793\/ztag020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjdh\/article-pdf\/7\/2\/ztag020\/66712793\/ztag020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T04:26:57Z","timestamp":1771388817000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjdh\/article\/doi\/10.1093\/ehjdh\/ztag020\/8455665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,27]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjdh\/ztag020","relation":{},"ISSN":["2634-3916"],"issn-type":[{"value":"2634-3916","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,1,27]]},"article-number":"ztag020"}}