{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:22:41Z","timestamp":1788535361153,"version":"build-2803163510"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF22OC0079241"],"award-info":[{"award-number":["NNF22OC0079241"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centre for Regional Development in the Capital Region of Denmark"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Heart failure (HF) in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) is associated with poor prognosis but often under-recognized. Coronary computed tomography angiography (CCTA), increasingly used in NSTE-ACS, contains cardiopulmonary features not routinely assessed for HF. We evaluated whether an artificial intelligence (AI) algorithm applied to CCTA could identify HF likelihood in NSTE-ACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this retrospective external validation study, the AI algorithm was applied without retraining or recalibration to CCTA scans from 1009 patients with NSTE-ACS in the VERDICT trial. Using a pre-specified threshold, patients were classified as low or high AI likelihood of HF. The primary outcome was HF during index hospitalization. The secondary outcome was post-discharge HF hospitalization among patients discharged alive without HF, with analyses adjusted for global registry of acute coronary events score &amp;gt;140 and severe coronary artery disease. Death was treated as a competing risk. Overall, 838 patients (83%) were classified as low AI likelihood and 171 (17%) as high. During index hospitalization, HF was diagnosed in 10 patients (1%) with low AI likelihood and 12 (7%) with high. Sensitivity was 55%, specificity 84%, positive predictive value 7%, and negative predictive value 99%. High AI likelihood was associated with increased risk of index HF (subdistribution hazard ratio, 5.39, 95% confidence interval (CI) 2.32\u201312.50). After discharge, HF hospitalization occurred in 25 patients (3%) with low AI likelihood and 14 (8%) with high. High AI likelihood remained associated with HF hospitalization (subdistribution hazard ratio 2.56, 95% CI 1.34\u20134.90).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AI-based CCTA analysis identified a large low-risk subgroup and a smaller subgroup at increased HF risk, supporting further evaluation of opportunistic HF assessment from CCTA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjdh\/ztag133","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:15:47Z","timestamp":1786706147000},"source":"Crossref","is-referenced-by-count":0,"title":["Artificial intelligence detection of heart failure on coronary computed tomography angiography: external validation in patients with non-ST-segment elevation acute coronary syndrome"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-7357","authenticated-orcid":false,"given":"Anne Sophie Overgaard","family":"Olesen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Bispebjerg Bakke 23, 2400 Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen ,","place":["Denmark"]},{"name":"British Heart Foundation Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow , 126 University Place, G12 8TA Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9544-6114","authenticated-orcid":false,"given":"Kristina Cecilia","family":"Miger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Bispebjerg Bakke 23, 2400 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3081-1547","authenticated-orcid":false,"given":"Silas Nyboe","family":"\u00d8rting","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-0693","authenticated-orcid":false,"given":"Jens","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6328-902X","authenticated-orcid":false,"given":"Marleen","family":"de Bruijne","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Radiology and Nuclear Medicine, Erasmus University Medical Center , Rotterdam ,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8774-6563","authenticated-orcid":false,"given":"Mikael Ploug","family":"Boesen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen ,","place":["Denmark"]},{"name":"Department of Radiology, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-1554","authenticated-orcid":false,"given":"Klaus Fuglsang","family":"Kofoed","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen ,","place":["Denmark"]},{"name":"Department of Radiology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5511-4668","authenticated-orcid":false,"given":"Johannes","family":"Grand","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Amager and Hvidovre , Hvidovre ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3621-3775","authenticated-orcid":false,"given":"Jens Jakob","family":"Thune","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg , Bispebjerg Bakke 23, 2400 Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Blegdamsvej 3B, 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8903-4906","authenticated-orcid":false,"given":"Alasdair D","family":"Henderson","sequence":"additional","affiliation":[{"name":"British Heart Foundation Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow , 126 University Place, G12 8TA Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4306-5317","authenticated-orcid":false,"given":"Pardeep S","family":"Jhund","sequence":"additional","affiliation":[{"name":"British Heart Foundation Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow , 126 University Place, G12 8TA Glasgow 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