{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:09:29Z","timestamp":1782259769410,"version":"3.54.5"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To evaluate whether phase analysis imaging may predict treatment response and long-term prognosis after cardiac resynchronization therapy (CRT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Sixty-nine patients underwent myocardial perfusion imaging followed by CRT. Patients with ischaemic heart disease and non-ischaemic cardiomyopathy (NICM) were identified. Left ventricular (LV) mechanical dyssynchrony (LVMD) was assessed at phase analysis and the region of the latest mechanical activation was identified. LV pacing lead position was considered \u2018concordant\u2019 when located in the region of the latest mechanical activation, and \u2018discordant\u2019 otherwise. The \u20186 months post-CRT\u2019\/\u2018baseline\u2019 ratio of LV ejection fraction was computed as a measure of CRT response. LVMD was revealed in 47\/69 patients, 27 of whom (57%) had a concordant LV lead implantation. Only concordant pacing was associated with LV functional improvement (ejection fraction ratio: 1.28 \u00b1 0.25 vs. 1.11 \u00b1 0.32 in discordant stimulation, P = 0.028). However, this relationship persisted only in patients with NICM (P &amp;lt; 0.001), while it disappeared in those with ischaemic heart disease (P = NS). Twenty-eight events occurred during 30 \u00b1 21 months follow-up. While discordant LV lead location was the major predictor of unfavourable prognosis (hazard ratio 3.29, 95% confidence interval 1.25\u20138.72; P = 0.016), this relationship was confirmed only in patients with NICM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Phase analysis of myocardial perfusion imaging may guide CRT implantation, identifying patients who would most likely benefit from this procedure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyad004","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T19:50:32Z","timestamp":1687204232000},"source":"Crossref","is-referenced-by-count":1,"title":["Prognostic impact of cardiac resynchronization therapy guided by phase analysis: a CZT study"],"prefix":"10.1093","volume":"1","author":[{"given":"Riccardo","family":"Liga","sequence":"first","affiliation":[{"name":"Dipartimento di Patologia Chirurgica, Medica, Molecolare e dell\u2019Area Critica, University of Pisa , Pisa , Italy"},{"name":"Cardio-thoracic and Vascular Department, University Hospital of Pisa , Pisa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Startari","sequence":"additional","affiliation":[{"name":"Fondazione Toscana Gabriele Monasterio , Via Moruzzi, 1 , 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Spatafora","sequence":"additional","affiliation":[{"name":"Cardio-thoracic and Vascular Department, University Hospital of Pisa , Pisa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Michelotti","sequence":"additional","affiliation":[{"name":"Cardio-thoracic and Vascular Department, University Hospital of Pisa , Pisa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Gimelli","sequence":"additional","affiliation":[{"name":"Fondazione Toscana Gabriele Monasterio , Via Moruzzi, 1 , 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"2023083116223113900_qyad004-B1","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"2023083116223113900_qyad004-B2","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/eurheartj\/ehab364","article-title":"2021 ESC guidelines on cardiac pacing and cardiac resynchronization therapy","volume":"42","author":"Glikson","year":"2021","journal-title":"Eur Heart 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patients","volume":"28","author":"Ypenburg","year":"2007","journal-title":"Eur Heart J"},{"key":"2023083116223113900_qyad004-B6","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1007\/s12350-021-02796-3","article-title":"Predictive values of left ventricular mechanical dyssynchrony for CRT response in heart failure patients with different pathophysiology","volume":"29","author":"He","year":"2022","journal-title":"J Nucl Cardiol"},{"key":"2023083116223113900_qyad004-B7","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.026943","article-title":"Myocardial revascularization in patients with ischemic cardiomyopathy: for whom and how","volume":"12","author":"Liga","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"2023083116223113900_qyad004-B8","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1007\/s00259-015-3008-7","article-title":"Relationships between myocardial perfusion abnormalities and poststress left ventricular functional impairment on cadmium-zinc-telluride imaging","volume":"42","author":"Gimelli","year":"2015","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2023083116223113900_qyad004-B9","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s12350-017-1036-3","article-title":"Interactions between myocardial sympathetic denervation and left ventricular mechanical dyssynchrony: a CZT analysis","volume":"26","author":"Gimelli","year":"2019","journal-title":"J Nucl Cardiol"},{"key":"2023083116223113900_qyad004-B10","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.amjcard.2010.11.010","article-title":"Defining left bundle branch block in the era of cardiac resynchronization therapy","volume":"107","author":"Strauss","year":"2011","journal-title":"Am J Cardiol"}],"container-title":["European Heart Journal - Imaging Methods and 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