{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:33:44Z","timestamp":1793370824542,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/17\/48\/32907"],"award-info":[{"award-number":["FS\/17\/48\/32907"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart and Lung Foundation","doi-asserted-by":"publisher","award":["20210635"],"award-info":[{"award-number":["20210635"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart and Lung Foundation","doi-asserted-by":"publisher","award":["20220675"],"award-info":[{"award-number":["20220675"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Region of Scania, Sweden, Bundy Academy, Swedish Heart Association, Swedish Society of Cardiology, Lisa och Johan Gr\u00f6nbergs Stiftelse"},{"name":"Swedish Society for Clinical Physiology"},{"name":"British Heart Foundation Senior Clinical Research Fellowships"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Left ventricular (LV) pressure-volume (PV) loops provide gold-standard physiological information but require invasive measurements of ventricular intracavity pressure, limiting clinical and research applications. A non-invasive method for the computation of PV loops from magnetic resonance imaging and brachial cuff blood pressure has recently been proposed. Here we evaluated the fidelity of the non-invasive PV algorithm against invasive LV pressures in humans.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Four heart failure patients with EF &amp;lt; 35% and LV dyssynchrony underwent cardiovascular magnetic resonance (CMR) imaging and subsequent LV catheterization with sequential administration of two different intravenous metabolic substrate infusions (insulin\/dextrose and lipid emulsion), producing eight datasets at different haemodynamic states. Pressure-volume loops were computed from CMR volumes combined with (i) a time-varying elastance function scaled to brachial blood pressure and temporally stretched to match volume data, or (ii) invasive pressures averaged from 19 to 30 sampled beats. Method comparison was conducted using linear regression and Bland-Altman analysis. Non-invasively derived PV loop parameters demonstrated high correlation and low bias when compared to invasive data for stroke work (R2 = 0.96, P &amp;lt; 0.0001, bias 4.6%), potential energy (R2 = 0.83, P = 0.001, bias 1.5%), end-systolic pressure-volume relationship (R2 = 0.89, P = 0.0004, bias 5.8%), ventricular efficiency (R2 = 0.98, P &amp;lt; 0.0001, bias 0.8%), arterial elastance (R2 = 0.88, P = 0.0006, bias \u22128.0%), mean external power (R2 = 0.92, P = 0.0002, bias 4.4%), and energy per ejected volume (R2 = 0.89, P = 0.0001, bias 3.7%). Variations in estimated end-diastolic pressure did not significantly affect results (P &amp;gt; 0.05 for all). Intraobserver analysis after one year demonstrated 0.9\u20133.4% bias for LV volumetry and 0.2\u20135.4% for PV loop-derived parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pressure-volume loops can be precisely and accurately computed from CMR imaging and brachial cuff blood pressure in humans.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyad035","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T18:49:01Z","timestamp":1698259741000},"source":"Crossref","is-referenced-by-count":28,"title":["Non-invasive left ventricular pressure-volume loops from cardiovascular magnetic resonance imaging and brachial blood pressure: validation using pressure catheter measurements"],"prefix":"10.1093","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2262-3562","authenticated-orcid":false,"given":"Per M","family":"Arvidsson","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford , Oxford OX3 9DU , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peregrine G","family":"Green","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre, John Radcliffe Hospital , Oxford OX3 9DU , United Kingdom"},{"name":"Department of Physiology, Anatomy and Genetics, University of Oxford , Oxford OX1 3PT , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford , Oxford OX3 9DU , United Kingdom"},{"name":"Department of Cardiovascular Medicine, Heart and Lung Research Institute , Papworth Road , Cambridge CB2 0AY, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8036-6253","authenticated-orcid":false,"given":"Mayooran","family":"Shanmuganathan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford , Oxford OX3 9DU , United Kingdom"},{"name":"Cardiology Department, Buckinghamshire Healthcare NHS Trust, Wycombe Hospital , Queen Alexandra Road , High Wycombe HP11 2TT, United Kingdom"},{"name":"Heart Transplant Department, Harefield Hospital, Royal Brompton and Harefield Hospitals , Hill End Road , Harefield UB9 6JH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2848-3326","authenticated-orcid":false,"given":"Einar","family":"Heiberg","sequence":"additional","affiliation":[{"name":"Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Sk\u00e5ne University Hospital , Lund , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Luigi","family":"De Maria","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre, John Radcliffe Hospital , Oxford OX3 9DU , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-3159","authenticated-orcid":false,"given":"H\u00e5kan","family":"Arheden","sequence":"additional","affiliation":[{"name":"Clinical Physiology, Department of Clinical Sciences Lund, Lund University, Sk\u00e5ne University Hospital , Lund , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8453-6133","authenticated-orcid":false,"given":"Neil","family":"Herring","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy and Genetics, University of Oxford , Oxford OX1 3PT , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver J","family":"Rider","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford , Oxford OX3 9DU , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"2024010307191102100_qyad035-B1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1152\/physrev.1990.70.2.247","article-title":"Ventricular energetics","volume":"70","author":"Suga","year":"1990","journal-title":"Physiol Rev"},{"key":"2024010307191102100_qyad035-B2","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"2024010307191102100_qyad035-B3","doi-asserted-by":"crossref","first-page":"e008493","DOI":"10.1161\/CIRCIMAGING.118.008493","article-title":"Noninvasive quantification of pressure-volume loops from brachial pressure and cardiovascular magnetic resonance","volume":"12","author":"Seemann","year":"2019","journal-title":"Circ Cardiovasc Imaging"},{"key":"2024010307191102100_qyad035-B4","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1161\/01.CIR.94.10.2497","article-title":"Single-beat estimation of end-systolic pressure-volume relation in humans","volume":"94","author":"Senzaki","year":"1996","journal-title":"Circulation"},{"key":"2024010307191102100_qyad035-B5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/cpf.12718","article-title":"Non-invasive quantification of pressure-volume loops from cardiovascular magnetic resonance at rest and during dobutamine stress","volume":"41","author":"Sj\u00f6berg","year":"2021","journal-title":"Clin Physiol Funct Imaging"},{"key":"2024010307191102100_qyad035-B6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/CIRCULATIONAHA.122.062166","article-title":"Retained metabolic flexibility of the failing human heart","volume":"148","author":"Watson","year":"2023","journal-title":"Circulation"},{"key":"2024010307191102100_qyad035-B7","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","article-title":"2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European society of cardiology (ESC). developed with the special contribution of the heart failure association (HFA) of the ESC","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2024010307191102100_qyad035-B8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.amjcard.2022.09.001","article-title":"Noninvasive assessment of left ventricular pressure-volume relations: inter- and intraobserver variability and assessment across heart failure subtypes","volume":"184","author":"Edlund","year":"2022","journal-title":"Am J Cardiol"},{"key":"2024010307191102100_qyad035-B9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/01.CIR.86.2.513","article-title":"Effective arterial elastance as index of arterial vascular load in humans","volume":"86","author":"Kelly","year":"1992","journal-title":"Circulation"},{"key":"2024010307191102100_qyad035-B10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1475-925X-11-73","article-title":"Beat-to-beat estimation of the continuous left and right cardiac elastance from metrics commonly available in clinical settings","volume":"11","author":"Stevenson","year":"2012","journal-title":"Biomed Eng Online"},{"key":"2024010307191102100_qyad035-B11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1053\/j.jvca.2017.09.032","article-title":"Accuracy of a simulation algorithm for modelling LV contractility, diastolic capacitance, and energetics using data available from common hemodynamic monitors and echocardiography","volume":"32","author":"Heerdt","year":"2018","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"2024010307191102100_qyad035-B12","first-page":"H498","article-title":"Total mechanical energy of a ventricle model and cardiac oxygen consumption","volume":"236","author":"Suga","year":"1979","journal-title":"Am J Physiol"},{"key":"2024010307191102100_qyad035-B13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"2024010307191102100_qyad035-B14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1475-925X-4-10","article-title":"Passive and active ventricular elastances of the left ventricle","volume":"4","author":"Zhong","year":"2005","journal-title":"Biomed Eng Online"},{"key":"2024010307191102100_qyad035-B15","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1161\/01.RES.32.3.314","article-title":"Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio","volume":"32","author":"Suga","year":"1973","journal-title":"Circ Res"},{"key":"2024010307191102100_qyad035-B16","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1161\/01.CIR.78.3.661","article-title":"Transmitral pressure-flow velocity relation. Importance of regional pressure gradients in the left ventricle during diastole","volume":"78","author":"Courtois","year":"1988","journal-title":"Circulation"},{"key":"2024010307191102100_qyad035-B17","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1161\/01.CIR.81.5.1688","article-title":"Physiological early diastolic intraventricular pressure gradient is lost during acute myocardial ischemia","volume":"81","author":"Courtois","year":"1990","journal-title":"Circulation"},{"key":"2024010307191102100_qyad035-B18","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1161\/01.CIR.82.4.1413","article-title":"Characterization of regional diastolic pressure gradients in the right ventricle","volume":"82","author":"Courtois","year":"1990","journal-title":"Circulation"},{"key":"2024010307191102100_qyad035-B19","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1152\/japplphysiol.00198.2020","article-title":"Quantification of left ventricular contribution to stroke work by longitudinal and radial force-length loops","volume":"129","author":"Seemann","year":"2020","journal-title":"J Appl Physiol (1985)"},{"key":"2024010307191102100_qyad035-B20","doi-asserted-by":"crossref","first-page":"W70","DOI":"10.1097\/RTI.0000000000000665","article-title":"Biventricular pressure-volume loop assessment before and after pulmonary valve replacement in tetralogy of fallot","volume":"37","author":"Binka","year":"2022","journal-title":"J Thorac Imaging"},{"key":"2024010307191102100_qyad035-B21","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1093\/cvr\/cvad028","article-title":"Mild hypothermia attenuates ischaemia\/reperfusion injury: insights from serial non-invasive pressure-volume loops","volume":"119","author":"Berg","year":"2023","journal-title":"Cardiovasc Res"},{"key":"2024010307191102100_qyad035-B22","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1161\/CIRCULATIONAHA.105.540435","article-title":"Hemodynamic effects of long-term cardiac resynchronization therapy: analysis by pressure-volume loops","volume":"113","author":"Steendijk","year":"2006","journal-title":"Circulation"},{"key":"2024010307191102100_qyad035-B23","doi-asserted-by":"crossref","first-page":"H723","DOI":"10.1152\/ajpheart.00555.2003","article-title":"Quantification of left ventricular mechanical dyssynchrony by conductance catheter in heart failure patients","volume":"286","author":"Steendijk","year":"2004","journal-title":"Am J Physiol Hear Circ Physiol"},{"key":"2024010307191102100_qyad035-B24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1161\/CIRCIMAGING.112.980037","article-title":"Cardiac MRI: a new gold standard for ventricular volume quantification during high-intensity exercise","volume":"6","author":"La Gerche","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"2024010307191102100_qyad035-B25","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1532-429X-15-96","article-title":"Moderate intensity supine exercise causes decreased cardiac volumes and increased outer volume variations: a cardiovascular magnetic resonance study","volume":"15","author":"Steding-Ehrenborg","year":"2013","journal-title":"J Cardiovasc Magn Reson"},{"key":"2024010307191102100_qyad035-B26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12968-018-0491-6","article-title":"Cardiac work is related to creatine kinase energy supply in human heart failure: A cardiovascular magnetic resonance spectroscopy study","volume":"20","author":"Gabr","year":"2018","journal-title":"J Cardiovasc Magn Reson"},{"key":"2024010307191102100_qyad035-B27","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s12471-016-0811-0","article-title":"How to diagnose heart failure with preserved ejection fraction: the value of invasive stress testing","volume":"24","author":"Huis in \u2018t Veld","year":"2016","journal-title":"Neth Hear J"},{"key":"2024010307191102100_qyad035-B28","doi-asserted-by":"crossref","first-page":"e13160","DOI":"10.14814\/phy2.13160","article-title":"The quest for load-independent left ventricular chamber properties: exploring the normalized pressure\u2013volume loop","volume":"5","author":"Kohli","year":"2017","journal-title":"Physiol Rep"},{"key":"2024010307191102100_qyad035-B29","doi-asserted-by":"crossref","first-page":"H181","DOI":"10.1152\/ajpheart.00650.2020","article-title":"E-wave asymmetry elucidates diastolic ventricular stiffness-relaxation coupling: model-based prediction with in vivo validation","volume":"320","author":"Amrute","year":"2021","journal-title":"Am J Physiol Hear Circ Physiol"},{"key":"2024010307191102100_qyad035-B30","doi-asserted-by":"crossref","first-page":"H534","DOI":"10.1152\/ajpheart.01268.2006","article-title":"Left ventricular volume measurement in mice by conductance catheter: evaluation and optimization of calibration","volume":"293","author":"Nielsen","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2024010307191102100_qyad035-B31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00395-005-0542-7","article-title":"Direct comparison of magnetic resonance imaging and conductance microcatheter in the evaluation of left ventricular function in mice","volume":"101","author":"Jacoby","year":"2006","journal-title":"Basic Res Cardiol"},{"key":"2024010307191102100_qyad035-B32","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/01.CIR.81.2.703","article-title":"The conductance method of left ventricular volume estimation. Methodologic limitations put into perspective","volume":"81","author":"Burkhoff","year":"1990","journal-title":"Circulation"}],"container-title":["European Heart Journal - Imaging Methods and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjimp\/advance-article-pdf\/doi\/10.1093\/ehjimp\/qyad035\/52543786\/qyad035.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjimp\/article-pdf\/1\/2\/qyad035\/54932119\/qyad035.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjimp\/article-pdf\/1\/2\/qyad035\/54932119\/qyad035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T07:20:05Z","timestamp":1704266405000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjimp\/article\/doi\/10.1093\/ehjimp\/qyad035\/7329705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,9,8]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjimp\/qyad035","relation":{},"ISSN":["2755-9637"],"issn-type":[{"value":"2755-9637","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9]]},"published":{"date-parts":[[2023,9]]},"article-number":"qyad035"}}