{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:25:00Z","timestamp":1778808300660,"version":"3.51.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":63,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000860","name":"European Society of Cardiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000860","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ESC Research","award":["App000080404"],"award-info":[{"award-number":["App000080404"]}]},{"DOI":"10.13039\/501100005609","name":"University of Turku","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005609","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Epicardial adipose tissue (EAT) has emerged as a mediator between systemic inflammatory disorders and cardiovascular disease, and may therefore play a role in the pathophysiology of cardiac involvement in systemic sclerosis (SSc). The aim of this study was to assess the correlation between EAT and left ventricular (LV) function, and to determine the prognostic value of EAT in patients with SSc.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Consecutive patients with SSc who underwent non-contrast thorax computed tomography and echocardiography were included. EAT mass was quantified using dedicated software. The study endpoint was all-cause mortality. A total of 230 SSc patients (age 53 \u00b1 15 years, 14% male) were included. The median value of EAT mass was 67\u2005g (interquartile range: 45\u2013101\u2005g). Patients with increased EAT mass (\u226567\u2005g) showed more impaired LV diastolic function as compared with patients with less EAT mass (&amp;lt;67\u2005g), and even after adjusting for age and comorbidities, EAT mass was independently associated with LV diastolic function parameters. During a median follow-up of 8 years, 42 deaths occurred. Kaplan\u2013Meier analysis showed that patients with increased EAT mass had higher all-cause mortality rate as compared with patients with less EAT mass (29% vs. 7%; P &amp;lt; 0.001). In the multivariable analysis, EAT was independently associated with all-cause mortality after adjusting for important covariates (HR: 1.006; 95% CI: 1.001\u20131.010).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with SSc, EAT is independently associated with LV diastolic dysfunction and higher mortality rate.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyad037","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T22:56:45Z","timestamp":1699397805000},"source":"Crossref","is-referenced-by-count":5,"title":["Epicardial adipose tissue in patients with systemic sclerosis"],"prefix":"10.1093","volume":"1","author":[{"given":"Xu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333 ZA , The Netherlands"},{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease , XCF3+6R6, Chaoyang, Beijing 100029 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steele C","family":"Butcher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333 ZA , The Netherlands"},{"name":"Department of Cardiology, Royal Perth Hospital , Victoria Square, Perth WA 6000, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-1777","authenticated-orcid":false,"given":"Rinchyenkhand","family":"Myagmardorj","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mongolia-Japan Teaching Hospital, Mongolian National University of Medical Sciences , Botanic street, Ulaanbaatar 13270 , Mongolia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie I E","family":"Liem","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333 ZA , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333 ZA , The Netherlands"},{"name":"Hospital University Germans Trias i Pujol, Fundaci\u00f3 Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol , Carretera de Canyet, s\/n, Badalona 08916 , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7368-0500","authenticated-orcid":false,"given":"Jeroen J","family":"Bax","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333 ZA , The Netherlands"},{"name":"Heart Center, University of Turku and Turku University Hospital , U-sairaala, Kiinamyllynkatu 4-8, Turku 20521 , Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeska K","family":"De Vries-Bouwstra","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mongolia-Japan Teaching Hospital, Mongolian National University of Medical Sciences , Botanic street, Ulaanbaatar 13270 , Mongolia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-5769","authenticated-orcid":false,"given":"Nina Ajmone","family":"Marsan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , Albinusdreef 2, Leiden 2333 ZA , The 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