{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:55:39Z","timestamp":1782845739618,"version":"3.54.5"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Aortic root motion is suspected to contribute to proximal aortic dissection. While motion of the aorta in four dimensions can be traced with real-time imaging, displacement and rotation in quantitative terms remain unknown. The hypothesis was to show feasibility of quantification of three-dimensional aortic root motion from dynamic CT imaging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Dynamic CT images of 40 patients for coronary assessment were acquired using a dynamic protocol. Scans were ECG-triggered and segmented in 10 time-stepped phases (0\u201390%) per cardiac cycle. With identification of the sinotubular junction (STJ), a patient-specific co-ordinate system was created with the z-axis (out-of-plane) parallel to longitudinal direction. The left and right coronary ostia were traced at each time-step to quantify downward motion in reference to the STJ plane, motion within the STJ plane (in-plane), and the degree of rotation. Enrolled individuals had an age of 65 \u00b1 12, and 14 were male (35%). The out-of-plane motion was recorded with the largest displacement of 10.26 \u00b1 2.20 and 8.67 \u00b1 1.69\u2005mm referenced by left and right coronary ostia, respectively. The mean downward movement of aortic root was 9.13 \u00b1 1.86\u2005mm. The largest in-plane motion was recorded at 9.17 \u00b1 2.33\u2005mm and 6.51 \u00b1 1.75\u2005mm referenced by left and right coronary ostia, respectively. The largest STJ in-plane motion was 7.37 \u00b1 1.96\u2005mm, and rotation of the aortic root was 11.8 \u00b1 4.60\u00b0.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In vivo spatial and temporal displacement of the aortic root can be identified and quantified from multiphase ECG-gated contrast-enhanced CT images. Knowledge of normal 4D motion of the aortic root may help understand its biomechanical impact in patients with aortopathy and pre- and post-surgical or transcatheter aortic valve replacement.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyae007","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T13:34:17Z","timestamp":1706880857000},"source":"Crossref","is-referenced-by-count":4,"title":["Four-dimensional analysis of aortic root motion in normal population using retrospective multiphase computed tomography"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6843-6466","authenticated-orcid":false,"given":"Xun","family":"Yuan","sequence":"first","affiliation":[{"name":"Cardiology and Aortic Centre, Royal Brompton & Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , Sydney Street, London SW3 6NP , UK"},{"name":"National Heart and Lung Institute, School of Medicine, Imperial College London , Exhibition Road, London SW7 2BX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"Kan","sequence":"additional","affiliation":[{"name":"Center for Vascular Surgery and Wound Care, Jinshan Hospital, Fudan University , Shanghai , China"},{"name":"Department of Chemical Engineering, Imperial College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianpeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3051-4355","authenticated-orcid":false,"given":"Saeed","family":"Mirsadraee","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, School of Medicine, Imperial College London , Exhibition Road, London SW7 2BX , UK"},{"name":"Department of Radiology, Royal Brompton & Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Mittal","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, School of Medicine, Imperial College London , Exhibition Road, London SW7 2BX , UK"},{"name":"Department of Radiology, Royal Brompton & Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Radiology, East and North Hertfordshire NHS Foundation Trust , Middlesex , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Saunders","sequence":"additional","affiliation":[{"name":"Department of Radiology, East and North Hertfordshire NHS Foundation Trust , Middlesex , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Yun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Imperial College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-8030","authenticated-orcid":false,"given":"Christoph A","family":"Nienaber","sequence":"additional","affiliation":[{"name":"Cardiology and Aortic Centre, Royal Brompton & Harefield Hospitals, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , Sydney Street, London SW3 6NP , UK"},{"name":"National Heart and Lung Institute, School of Medicine, Imperial College London , Exhibition Road, London SW7 2BX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"2024071810063194600_qyae007-B1","doi-asserted-by":"crossref","first-page":"16071","DOI":"10.1038\/nrdp.2016.71","article-title":"Aortic dissection","volume":"2","author":"Nienaber","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2024071810063194600_qyae007-B2","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","article-title":"2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. 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