{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:09:00Z","timestamp":1783984140932,"version":"3.55.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"DOI":"10.13039\/100030692","name":"Intramural Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Z01-HL006257, Z01-HL006213, and Z01-HL006039"],"award-info":[{"award-number":["Z01-HL006257, Z01-HL006213, and Z01-HL006039"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Swedish Society for Medical Research","doi-asserted-by":"publisher","award":["SSMF PD20-004"],"award-info":[{"award-number":["SSMF PD20-004"]}],"id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart Lung Foundation","doi-asserted-by":"publisher","award":["20210205"],"award-info":[{"award-number":["20210205"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart Lung Foundation","doi-asserted-by":"publisher","award":["20220463"],"award-info":[{"award-number":["20220463"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006358","name":"Foundation Blanceflor","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006358","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Pressure\u2013volume (PV) loops have utility in the evaluation of cardiac pathophysiology but require invasive measurements. Recently, a time-varying elastance model to derive PV loops non-invasively was proposed, using left ventricular (LV) volume by cardiovascular magnetic resonance (CMR) and brachial cuff pressure as inputs. Validation was performed using CMR and pressure measurements acquired on the same day, but not simultaneously, and without varying pre-loads. This study validates the non-invasive elastance model used to estimate PV loops at varying pre-loads, compared with simultaneous measurements of invasive pressure and volume from real-time CMR, acquired concurrent to an inferior vena cava (IVC) occlusion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We performed dynamic PV loop experiments under CMR guidance in 15 pigs (n = 7 na\u00efve, n = 8 with ischaemic cardiomyopathy). Pre-load was altered by IVC occlusion, while simultaneously acquiring invasive LV pressures and volumes from real-time CMR. Pairing pressure and volume signals yielded invasive PV loops, and model-based PV loops were derived using real-time LV volumes. Haemodynamic parameters derived from invasive and model-based PV loops were compared. Across 15 pigs, 297 PV loops were recorded. Intra-class correlation coefficient (ICC) agreement was excellent between model-based and invasive parameters: stroke work (bias = 0.007 \u00b1 0.03\u2005J, ICC = 0.98), potential energy (bias = 0.02 \u00b1 0.03\u2005J, ICC = 0.99), ventricular energy efficiency (bias = \u22120.7 \u00b1 2.7%, ICC = 0.98), contractility (bias = 0.04 \u00b1 0.1\u2005mmHg\/mL, ICC = 0.97), and ventriculoarterial coupling (bias = 0.07 \u00b1 0.15, ICC = 0.99). All haemodynamic parameters differed between na\u00efve and cardiomyopathy animals (P &amp;lt; 0.05). The invasive vs. model-based PV loop dice similarity coefficient was 0.88 \u00b1 0.04.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>An elastance model\u2013based estimation of PV loops and associated haemodynamic parameters provided accurate measurements at transient loading conditions compared with invasive PV loops.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyae016","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T13:30:19Z","timestamp":1709645419000},"source":"Crossref","is-referenced-by-count":5,"title":["Non-invasive pressure\u2013volume loops using the elastance model and CMR: a porcine validation at transient pre-loads"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3074-5380","authenticated-orcid":false,"given":"Felicia","family":"Seemann","sequence":"first","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health , 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2848-3326","authenticated-orcid":false,"given":"Einar","family":"Heiberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Clinical Physiology, Skane University Hospital, Lund University , Entr\u00e9gatan 7, 221 85 Lund , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G","family":"Bruce","sequence":"additional","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health , 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaffar M","family":"Khan","sequence":"additional","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health , 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Potersnak","sequence":"additional","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health , 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Ramasawmy","sequence":"additional","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health , 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health , 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-3159","authenticated-orcid":false,"given":"H\u00e5kan","family":"Arheden","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Clinical Physiology, Skane University Hospital, Lund University , Entr\u00e9gatan 7, 221 85 Lund , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Lederman","sequence":"additional","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health , 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne E","family":"Campbell-Washburn","sequence":"additional","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health , 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"2024071810064082900_qyae016-B1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.hfc.2008.11.008","article-title":"Invasive hemodynamic assessment in heart failure","volume":"5","author":"Borlaug","year":"2009","journal-title":"Heart Fail Clin"},{"key":"2024071810064082900_qyae016-B2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/ejhf.1436","article-title":"The role of ventricular\u2013arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions. 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