{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:35:11Z","timestamp":1773113711384,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":129,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>A major limitation of cardiac positron emission tomography (PET) with F18-fluorodeoxyglucose (F18-FDG) for the evaluation of cardiac sarcoidosis (CS) is associated with physiologic myocardial glucose uptake. The optimal dietary protocol to suppress physiologic myocardial F18-FDG uptake is not well-established. We aimed to evaluate the diagnostic performance of a novel dietary preparation using a ketone-based infant formula.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Between 2018 and 2021, consecutive studies using a ketogenic dietary preparation were identified (n = 198). The rate of non-diagnostic studies due to failure to suppress myocardial glucose was 7.1% (n = 14) with a similar incidence in diabetics (n = 6, 8.1%). Among studies reported to have no inflammation (n = 137), 130 studies (66%) had mean myocardial standardized uptake value (SUV) less than or equal to mean blood pool SUV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patient preparation with a ketone-based infant formula resulted in low rate of inappropriate myocardial glucose suppression in patients undergoing F18-FDG cardiac PET to evaluate CS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyae037","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T12:12:08Z","timestamp":1715256728000},"source":"Crossref","is-referenced-by-count":5,"title":["Standardized ketogenic dietary preparation for metabolic PET imaging in suspected and known cardiac sarcoidosis"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8271-6648","authenticated-orcid":false,"given":"Erika","family":"Hutt","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic Foundation , 9500 Euclid Ave, Cleveland, OH, 44195 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghazaleh","family":"Goldar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, University of Iowa Health Care , Iowa City, IA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael A","family":"Jaber","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic Foundation , 9500 Euclid Ave, Cleveland, OH, 44195 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C","family":"Cremer","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Radiology, Northwestern Medicine , Chicago, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"2024071810105787500_qyae037-B1","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1253\/circj.CJ-19-0508","article-title":"JCS 2016 guideline on diagnosis and treatment of cardiac sarcoidosis\u2014digest version","volume":"83","author":"Terasaki","year":"2019","journal-title":"Circ J"},{"key":"2024071810105787500_qyae037-B2","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.hrthm.2014.03.043","article-title":"HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis","volume":"11","author":"Birnie","year":"2014","journal-title":"Heart Rhythm"},{"key":"2024071810105787500_qyae037-B3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s12350-016-0502-7","article-title":"Patient preparation for cardiac fluorine-18 fluorodeoxyglucose positron emission tomography imaging of inflammation","volume":"24","author":"Osborne","year":"2017","journal-title":"J Nucl Cardiol"},{"key":"2024071810105787500_qyae037-B4","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.2967\/jnumed.117.196287","article-title":"Joint SNMMI-ASNC expert consensus document on the role of 18F-FDG PET\/CT in cardiac sarcoid detection and therapy monitoring","volume":"58","author":"Chareonthaitawee","year":"2017","journal-title":"J Nucl Med"},{"key":"2024071810105787500_qyae037-B5","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.2967\/jnumed.121.261981","article-title":"Comparison of the effect of three different dietary modifications on myocardial suppression in 18F-FDG PET\/CT evaluation of patients for suspected cardiac sarcoidosis","volume":"62","author":"Ozutemiz","year":"2021","journal-title":"J Nucl Med"},{"key":"2024071810105787500_qyae037-B6","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jcmg.2017.04.020","article-title":"Prognostic impact of extent, severity, and heterogeneity of abnormalities on 18F-FDG PET scans for suspected cardiac sarcoidosis","volume":"11","author":"Sperry","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"2024071810105787500_qyae037-B7","doi-asserted-by":"crossref","first-page":"1-10","DOI":"10.1093\/europace\/euad273","article-title":"Optimal left ventricular ejection fraction in risk stratification of patients with cardiac sarcoidosis","volume":"25","author":"Hutt","year":"2023","journal-title":"EP Europace"},{"key":"2024071810105787500_qyae037-B8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.nuclcard.2007.06.006","article-title":"Corridor4DM: the Michigan method for quantitative nuclear cardiology","volume":"14","author":"Ficaro","year":"2007","journal-title":"J Nucl Cardiol"},{"key":"2024071810105787500_qyae037-B9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/BF03164926","article-title":"Glucose tolerance and myocardial F-18 fluorodeoxyglucose uptake in normal regions in coronary heart disease patients","volume":"12","author":"Hasegawa","year":"1998","journal-title":"Ann Nucl Med"},{"key":"2024071810105787500_qyae037-B10","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/s12350-023-03209-3","article-title":"Utility of serum ketone levels for assessment of myocardial glucose suppression for 18F-fluorodeoxyglucose PET in patients referred for evaluation of endocarditis","volume":"30","author":"Madamanchi","year":"2023","journal-title":"J Nucl Cardiol"},{"key":"2024071810105787500_qyae037-B11","first-page":"770","article-title":"Comparison of exogenous ketone administration versus dietary carbohydrate restriction on myocardial glucose suppression: a crossover clinical trial","volume":"63","author":"Selvaraj","year":"2022","journal-title":"J Nucl Med"},{"key":"2024071810105787500_qyae037-B12","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00259-022-06062-7","article-title":"The utility of beta-hydroxybutyrate in detecting myocardial glucose uptake suppression in patients undergoing inflammatory [18F]-FDG PET studies","volume":"50","author":"Alfawara","year":"2023","journal-title":"Eur J Nucl Med Mol Imaging"}],"container-title":["European Heart Journal - Imaging Methods and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjimp\/advance-article-pdf\/doi\/10.1093\/ehjimp\/qyae037\/57465999\/qyae037.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjimp\/article-pdf\/2\/1\/qyae037\/58557536\/qyae037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjimp\/article-pdf\/2\/1\/qyae037\/58557536\/qyae037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T10:14:23Z","timestamp":1721297663000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjimp\/article\/doi\/10.1093\/ehjimp\/qyae037\/7667464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,16]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjimp\/qyae037","relation":{},"ISSN":["2755-9637"],"issn-type":[{"value":"2755-9637","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1]]},"published":{"date-parts":[[2024,1]]},"article-number":"qyae037"}}