{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:51:24Z","timestamp":1780487484051,"version":"3.54.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":137,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Leeds Clinical Research Facility"},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["CH\/16\/2\/32089 and FS\/CRA\/22\/23034"],"award-info":[{"award-number":["CH\/16\/2\/32089 and FS\/CRA\/22\/23034"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We aimed to identify the distinctive cardiovascular magnetic resonance (CMR) features of patients with left bundle branch block (LBBB) and heart failure with reduced ejection fraction (HFrEF) of presumed non-ischaemic aetiology. The secondary aim was to determine whether these individuals exhibit characteristics that could potentially serve as predictors of left ventricular ejection fraction (LVEF) recovery as compared with patients without LBBB.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We prospectively recruited patients with HFrEF (LVEF \u2264 40%) on echocardiography who were referred for early CMR examination. Patients with an established diagnosis of coronary artery disease and known structural or congenital heart disease were excluded. LV recovery was defined as achieving \u226510% absolute improvement to \u226540% in LVEF between baseline evaluation to CMR. A total of 391 patients were recruited including 115 (29.4%) with LBBB. Compared with HF patients without LBBB, those with LBBB exhibited larger left ventricles and smaller right ventricles, but no differences were observed with respect to LVEF (35.8 \u00b1 12 vs. 38 \u00b1 12%, P = 0.105). The overall rate of LV recovery from baseline echocardiogram to CMR (70 [42\u2013128] days) was not significantly different between LBBB and non-LBBB patients (27.8% vs. 31.5%, P = 0.47). Reduced LVEF remained an independent predictor of LV non-recovery only in patients with LBBB.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patients presenting with HFrEF and LBBB had larger LV cavities and smaller RV cavities than those without LBBB but no difference in prevalence of scar or ischaemia. The rates of LV recovery were similar between both groups, which supports current guidelines to defer device therapy until 3\u20136 months of guideline-directed medical therapy, rather than early CMR and device implantation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyae047","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T10:13:28Z","timestamp":1715940808000},"source":"Crossref","is-referenced-by-count":2,"title":["CMR characterization of patients with heart failure and left bundle branch block"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-4088","authenticated-orcid":false,"given":"Raluca","family":"Tomoaia","sequence":"first","affiliation":[{"name":"Biomedical Imaging Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Woodhouse, Leeds, West Yorkshire LS2 9JT , UK"},{"name":"Cardiology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Harrison","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Woodhouse, Leeds, West Yorkshire LS2 9JT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Bevis","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Woodhouse, Leeds, West Yorkshire LS2 9JT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Wahab","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Woodhouse, Leeds, West Yorkshire LS2 9JT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Thompson","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Woodhouse, Leeds, West Yorkshire LS2 9JT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E D","family":"Saunderson","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Woodhouse, Leeds, West Yorkshire LS2 9JT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eylem","family":"Levelt","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Woodhouse, Leeds, West Yorkshire LS2 9JT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Dall\u2019Armellina","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Woodhouse, Leeds, West Yorkshire LS2 9JT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Health, Norwich Medical School, University of East Anglia , Norfolk , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Greenwood","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Woodhouse, Leeds, West Yorkshire LS2 9JT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0997-4384","authenticated-orcid":false,"given":"Sven","family":"Plein","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Woodhouse, Leeds, West Yorkshire LS2 9JT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-7079","authenticated-orcid":false,"given":"Peter P","family":"Swoboda","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Woodhouse, Leeds, West Yorkshire LS2 9JT , 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