{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:51:42Z","timestamp":1753876302255,"version":"3.41.2"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":176,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Atrial fibrillation (AF) is a common comorbidity in non-ischaemic dilated cardiomyopathy (NIDCM) affecting conventional measures of left atrial (LA) function. We aimed to determine whether LA function analysis could identify patients at higher risk of major cardiovascular events (MACEs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A retrospective study of patients with NIDCM in AF referred to a single centre for transthoracic echocardiography (TTE) between 2015 and 2019. Peak atrial longitudinal strain (PALS) was measured along with LA emptying fraction and LA filling index (LAFI = E wave\/PALS). Cox regression analysis was conducted. A total of 153 patients were included [median age 74 years, left ventricular ejection fraction (LVEF) 35%], and 57 (37.3%) had MACE after a median follow-up of 3.2 years. LAFI was the only independent TTE parameter associated with MACE after adjustment for age, diabetes, LVEF, left ventricular global longitudinal strain (LV-GLS), and LA volume index [adjusted hazard ratio (HR) = 1.02 per point increase, P = 0.024], with the best cut-off at \u226515. LAFI \u226515 predicted each of MACE components when separately analysed: MACE HR = 1.95, 95% confidence interval (CI) 1.16\u20133.30; cardiovascular death HR = 3.68, 95% CI 1.41\u20139.56, heart failure admission HR = 2.13, 95% CI 1.19\u20133.80, and ventricular arrhythmia HR = 4.72, 95% CI 1.52\u201314.67. Higher LAFI was associated with worsening LV-GLS, E\/e\u2032, systolic pulmonary artery (PA) pressure, tricuspid annular plane systolic excursion, and right ventricular to PA coupling.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>LA deformation analysis is feasible in patients with NIDCM presenting with AF. LAFI may identify patients at higher risk of MACE and correlates with higher pulmonary pressures and worse right ventricular function, suggesting an elevation of left-sided ventricular pressures in patients with higher LAFI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyae063","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T15:50:09Z","timestamp":1719330609000},"source":"Crossref","is-referenced-by-count":0,"title":["Left atrial deformation analysis in patients with non-ischaemic dilated cardiomyopathy in atrial fibrillation"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1638-7820","authenticated-orcid":false,"given":"Eduard","family":"R\u00f3denas-Alesina","sequence":"first","affiliation":[{"name":"Department of Cardiology, Vall d\u2019Hebron University Hospital , Passeig de la Vall d\u2019Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Passeig de la Vall d\u2018Hebron 119-129, 08035 Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Lozano-Torres","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d\u2019Hebron University Hospital , Passeig de la Vall d\u2019Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Passeig de la Vall d\u2018Hebron 119-129, 08035 Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo Eduardo","family":"Tob\u00edas-Castillo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d\u2019Hebron University Hospital , Passeig de la Vall d\u2019Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Passeig de la Vall d\u2018Hebron 119-129, 08035 Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Badia-Molins","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d\u2019Hebron University Hospital , Passeig de la Vall d\u2019Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Passeig de la Vall d\u2018Hebron 119-129, 08035 Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Vila-Olives","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d\u2019Hebron University Hospital , Passeig de la Vall d\u2019Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Passeig de la Vall d\u2018Hebron 119-129, 08035 Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Calvo-Barcel\u00f3","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d\u2019Hebron University Hospital , Passeig de la Vall d\u2019Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Passeig de la Vall d\u2018Hebron 119-129, 08035 Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillem","family":"Casas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d\u2019Hebron University Hospital , Passeig de la Vall d\u2019Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Passeig de la Vall d\u2018Hebron 119-129, 08035 Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toni","family":"Soriano-Colom\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d\u2019Hebron University Hospital , Passeig de la Vall d\u2019Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Passeig de la Vall d\u2018Hebron 119-129, 08035 Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleix Olivella","family":"San Emeterio","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d\u2019Hebron University Hospital , Passeig de la Vall d\u2019Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Passeig de la Vall d\u2018Hebron 119-129, 08035 Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rub\u00e9n","family":"Fern\u00e1ndez-Galera","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d\u2019Hebron University Hospital , Passeig de la Vall d\u2019Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Passeig de la Vall d\u2018Hebron 119-129, 08035 Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana B","family":"M\u00e9ndez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d\u2019Hebron University Hospital , Passeig de la Vall d\u2019Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Passeig de la Vall d\u2018Hebron 119-129, 08035 Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A","family":"Barrab\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d\u2019Hebron University Hospital , Passeig de la Vall d\u2019Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Passeig de la Vall d\u2018Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares , Av. Monforte de Lemos, 3-5, 28029 Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Ferreira-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Vall d\u2019Hebron University Hospital , Passeig de la Vall d\u2019Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Passeig de la Vall d\u2018Hebron 119-129, 08035 Barcelona , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica , Av. 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