{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:08:12Z","timestamp":1788480492664,"version":"build-2803163510"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":102,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Leducq Foundation PRIMA","award":["22ARF02"],"award-info":[{"award-number":["22ARF02"]}]},{"name":"Leducq Foundation PRIMA","award":["CNPq N\u00b0 09\/2020"],"award-info":[{"award-number":["CNPq N\u00b0 09\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Rheumatic mitral stenosis (MS) frequently leads to impaired left atrial (LA) function because of pressure overload, highlighting the underlying atrial pathology. Two-dimensional speckle tracking echocardiography (2D-STE) offers early detection of LA dysfunction, potentially improving risk assessment in patients with MS. This study aims to evaluate the predictive value of LA function assessed by 2D-STE for clinical outcomes in patients with MS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Between 2011 and 2021, patients with MS underwent LA function assessment using 2D-STE, with focus on the reservoir phase (LASr). Atrial fibrillation (AF) development constituted the primary outcome, with death or valve replacement as the secondary outcome. Conditional inference trees were employed for analysis, validated through sample splitting. The study included 493 patients with MS (mean valve area 1.1 \u00b1 0.4 cm2, 84% female). At baseline, 166 patients (34%) had AF, with 62 patients (19%) developing AF during follow-up. LASr emerged as the primary predictor for new-onset AF, with a threshold of 17.9%. Over a mean 3.8-year follow-up, 125 patients (25%) underwent mitral valve replacement, and 32 patients (6.5%) died. A decision tree analysis identified key predictors such as age, LASr, severity of tricuspid regurgitation (TR), net atrioventricular compliance (Cn), and early percutaneous mitral valvuloplasty, especially in patients aged \u226449 years, where LASr, with a threshold of 12.8%, significantly predicted adverse outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>LASr emerged as a significant predictor of cardiovascular events in this MS cohort, validated through a decision tree analysis. Patients were stratified into low- or high-risk categories for adverse outcomes, taking into account LASr, age, TR severity, and Cn.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyae067","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T15:18:11Z","timestamp":1720797491000},"source":"Crossref","is-referenced-by-count":12,"title":["Left atrial function in patients with rheumatic mitral stenosis: addressing prognostic insights beyond atrial fibrillation prediction"],"prefix":"10.1093","volume":"2","author":[{"given":"Fernanda de Azevedo","family":"Figueiredo","sequence":"first","affiliation":[{"name":"Postgraduate Program of Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena, 190, Santa Efig\u00eania, Belo Horizonte, MG 30130 100 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Antonio M","family":"Esteves","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena, 190, Santa Efig\u00eania, Belo Horizonte, MG 30130 100 ,","place":["Brazil"]},{"name":"Hospital das Cl\u00ednicas, School of Medicine,Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena, 190, Santa Efig\u00eania, Belo Horizonte, MG 30130 100 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3737-7584","authenticated-orcid":false,"given":"Judy","family":"Hung","sequence":"additional","affiliation":[{"name":"Cardiac Ultrasound Lab, Massachusetts General Hospital, Harvard Medical School , 55 Fruit Street Boston, MA 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayana Flamini Arantes","family":"Gomes","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena, 190, Santa Efig\u00eania, Belo Horizonte, MG 30130 100 ,","place":["Brazil"]},{"name":"Hospital das Cl\u00ednicas, School of Medicine,Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena, 190, Santa Efig\u00eania, Belo Horizonte, MG 30130 100 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar Augusto","family":"Taconeli","sequence":"additional","affiliation":[{"name":"Department of Statistics, Universidade Federal do Paran\u00e1 , Curitiba Rua Cel. Francisco Her\u00e1clito dos Santos, 100 Centro Polit\u00e9cnico - Jardim das Am\u00e9rica sEdif\u00edcio do Setor de Ci\u00eancias Exatas, 81531-980, Curitiba, PR ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Negr\u00e3o","family":"Pantale\u00e3o","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, School of Medicine,Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena, 190, Santa Efig\u00eania, Belo Horizonte, MG 30130 100 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Assun\u00e7\u00e3o Rabello","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, School of Medicine,Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena, 190, Santa Efig\u00eania, Belo Horizonte, MG 30130 100 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio Mendes","family":"de Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, School of Medicine,Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena, 190, Santa Efig\u00eania, Belo Horizonte, MG 30130 100 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Marina Tacuri","family":"Chavez","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais , Av. Professor Alfredo Balena, 190, Santa Efig\u00eania, Belo Horizonte, MG 30130 100 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Blacktown Hospital , Blacktown Road, Blacktown, Sydney, NSW 2148 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6357-4808","authenticated-orcid":false,"given":"Aditya","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Blacktown Hospital , Blacktown Road, Blacktown, Sydney, NSW 2148 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Levine","sequence":"additional","affiliation":[{"name":"Cardiac Ultrasound Lab, Massachusetts General Hospital, Harvard Medical School , 55 Fruit Street Boston, MA 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8801-1828","authenticated-orcid":false,"given":"Maria Carmo Pereira","family":"Nunes","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais , Av. 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