{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:21:25Z","timestamp":1754558485122,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009033","name":"Center of Innovation Program","doi-asserted-by":"publisher","award":["JPMJPF2201"],"award-info":[{"award-number":["JPMJPF2201"]}],"id":[{"id":"10.13039\/501100009033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Laser speckle flowgraphy (LSFG) is a well-established tool renowned for its non-invasive and reproducible assessment of ocular blood flow. While rhythm control therapies, such as catheter ablation (CA), have shown promise in enhancing cognitive function in atrial fibrillation (AF) patients, the acute impact of CA on microcirculatory changes, particularly in ocular blood flow, remains a topic of limited understanding. The present study aims to delve into the potential of LSFG in detecting microcirculatory alterations following the restoration of sinus rhythm (SR) through CA in patients with AF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We studied 8 paroxysmal AF (Paf) and 20 persistent AF (PeAF) patients (mean age 67 \u00b1 6 years, 26% female) undergoing CA. Ocular blood flow was assessed using LSFG by measuring the mean blur rate (MBR) pre- and post-CA. Post-CA, all PeAF patients achieved SR restoration, resulting in a significant increase in tissue MBR (10.0 \u00b1 2.2 to 10.8 \u00b1 2.9, P = 0.021). In contrast, Paf patients showed no significant difference between pre- and post-MBR (12.0 \u00b1 2.7 vs. 11.8 \u00b1 2.6, P = 0.76).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>LSFG analysis effectively identified microcirculatory changes in patients undergoing CA for PeAF, suggesting that therapeutic interventions targeting the heart may have broader implications for ocular and cerebral health, establishing a novel \u2018cardio-oculo-cerebral relationship\u2019.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyae071","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T05:03:38Z","timestamp":1723093418000},"source":"Crossref","is-referenced-by-count":1,"title":["Ocular blood flow dynamics following sinus rhythm restoration through catheter ablation: laser speckle flowgraphy in patients with persistent atrial fibrillation"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0238-5944","authenticated-orcid":false,"given":"Nobuhiko","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Departments of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , 1-1, Seiryo-machi, Aoba-ku, Sendai 980-8574 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Nakano","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , 1-1, Seiryo-machi, Aoba-ku, Sendai 980-8574 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Nochioka","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , 1-1, Seiryo-machi, Aoba-ku, Sendai 980-8574 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine , Sendai ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kunikata","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine , Sendai ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine , Sendai ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7470-5236","authenticated-orcid":false,"given":"Satoshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , 1-1, Seiryo-machi, Aoba-ku, Sendai 980-8574 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"2025010217262546100_qyae071-B1","doi-asserted-by":"crossref","first-page":"e0173127","DOI":"10.1371\/journal.pone.0173127","article-title":"Longitudinal changes of ocular blood flow using laser speckle flowgraphy during normal pregnancy","volume":"12","author":"Sato","year":"2017","journal-title":"PLoS One"},{"key":"2025010217262546100_qyae071-B2","doi-asserted-by":"crossref","first-page":"e0117452","DOI":"10.1371\/journal.pone.0117452","article-title":"Relationship of ocular microcirculation, measured by laser speckle flowgraphy, and silent brain infarction in primary aldosteronism","volume":"10","author":"Kunikata","year":"2015","journal-title":"PLoS 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fibrillation","volume":"8","author":"Takahashi","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"key":"2025010217262546100_qyae071-B9","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.athoracsur.2018.11.067","article-title":"Cerebral circulation during retrograde cerebral perfusion: evaluation using laser speckle flowgraphy","volume":"107","author":"Kanda","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"2025010217262546100_qyae071-B10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jocn.2021.12.028","article-title":"Relation of middle cerebral artery flow velocity and risk of cognitive decline: a prospective community-based study","volume":"97","author":"Xiao","year":"2022","journal-title":"J Clin Neurosci"}],"container-title":["European Heart Journal - Imaging Methods and 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