{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:49:42Z","timestamp":1753876182181,"version":"3.41.2"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"vor","delay-in-days":159,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim of this retrospective study was to evaluate the ability of dynamic SPECT with quantitative analysis of myocardial blood flow (MBF) and myocardial flow reserve (MFR) for the detection of coronary artery disease (CAD) in patients with presumed new left bundle branch block (LBBB).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We evaluated the dynamic SPECT results from 174 consecutive patients with LBBB without a history of CAD from a single center. MBF was assessed at rest and during regadenoson (400 \u03bcg). Normal MFR was defined as \u2265 2.1. Left ventricular function and segmental perfusion were assessed from conventional gated SPECT. SPECT abnormalities were found in 17\/174 (10%) patients including a reversible SPECT defect in 4 patients (2.3%), a fixed defect in 12 patients (7%), and both in 1 patient. Global left ventricular function was normal despite a significant impairment of septal wall motion. Stress and rest MBF was decreased in the septum and the inferior wall compared with other walls (P &amp;lt; 0.0001), resulting in similar MFR. A reduced MFR was associated with a fixed defect (P = 0.04). Only 18 patients (10%) presented with a decreased MFR. They were more often referred to subsequent coronary angiography (8\/18, 44%) compared with patients with a normal MFR (9\/156, 6%, \u03c72 = 27.382, P &amp;lt; 0.0001). However, significant coronary lesions were finally found in only 4\/174 patients (2%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Although a decreased MFR was associated with a fixed defect on conventional perfusion imaging, the low rate of CAD finally demonstrated in this study questions the relevance of routine screening for CAD in patients with presumed new LBBB.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyae129","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T23:17:52Z","timestamp":1733872672000},"source":"Crossref","is-referenced-by-count":0,"title":["Usefulness of dynamic perfusion SPECT with quantitative assessment of myocardial perfusion reserve for the detection of myocardial ischaemia in patients with presumed new left bundle branch block"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1578-0922","authenticated-orcid":false,"given":"Alain","family":"Manrique","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, CHU de Caen Normandie, Normandie Univ, UNICAEN UR \u00a0 4650 PSIR, Avenue Cote de Nacre, 14000 Caen ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9ment","family":"Guery","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, CHU de Caen Normandie, Normandie Univ, UNICAEN UR \u00a0 4650 PSIR, Avenue Cote de Nacre, 14000 Caen ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2297-4418","authenticated-orcid":false,"given":"Damien","family":"Legallois","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CHU de Caen Normandie, Normandie Univ, UNICAEN, INSERM \u00a0 U1086 ANTICIPE, Avenue Cote de Nacre, 14000 Caen ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Richard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hopital Priv\u00e9 Saint Martin , Rue des Roquemonts, 14000 Caen ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Roule","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CHU de Caen Normandie, Normandie Universit\u00e9 , Avenue Cote de Nacre, 14000 Caen ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Agostini","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, CHU de Caen Normandie, Normandie Univ, UNICAEN UR \u00a0 4650 PSIR, Avenue Cote de Nacre, 14000 Caen ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,12,7]]},"reference":[{"key":"2025010217270155500_qyae129-B1","doi-asserted-by":"crossref","first-page":"e12572","DOI":"10.1111\/anec.12572","article-title":"Left bundle branch block: epidemiology, etiology, anatomic features, electrovectorcardiography, and classification proposal","volume":"24","author":"P\u00e9rez-Riera","year":"2019","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2025010217270155500_qyae129-B2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(13)61752-3","article-title":"The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective","volume":"383","author":"Mahmood","year":"2014","journal-title":"Lancet"},{"key":"2025010217270155500_qyae129-B3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0735-1097(87)80162-6","article-title":"Bundle branch block in patients with chronic coronary artery disease: angiographic correlates and prognostic significance","volume":"10","author":"Freedman","year":"1987","journal-title":"J Am Coll Cardiol"},{"key":"2025010217270155500_qyae129-B4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejheart.2006.04.011","article-title":"Left bundle branch block as a risk factor for progression to heart failure","volume":"9","author":"Zannad","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"2025010217270155500_qyae129-B5","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0002-9149(96)00160-9","article-title":"Natural history of isolated bundle branch block","volume":"77","author":"Fahy","year":"1996","journal-title":"Am J Cardiol"},{"key":"2025010217270155500_qyae129-B6","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1093\/eurheartj\/ehi580","article-title":"Bundle-branch block in middle-aged men: risk of complications and death over 28 years. 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