{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:07:00Z","timestamp":1785827220434,"version":"3.56.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":171,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Oxford National Institute for Health and Care Research"},{"DOI":"10.13039\/501100018942","name":"Biomedical Research Centre","doi-asserted-by":"publisher","award":["IS-BRC-1215-20008"],"award-info":[{"award-number":["IS-BRC-1215-20008"]}],"id":[{"id":"10.13039\/501100018942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u2018SmartHeart\u2019 EPSRC programme"},{"name":"London Medical Imaging and Artificial Intelligence Centre for Value Based Healthcare"},{"name":"Data to Early Diagnosis and Precision Medicine"},{"name":"Industrial Strategy Challenge Fund"},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union's Horizon 2020","award":["825903"],"award-info":[{"award-number":["825903"]}]},{"name":"NIHR Integrated Academic Training programme","award":["CL-2021-19-00"],"award-info":[{"award-number":["CL-2021-19-00"]}]},{"name":"Academic Clinical Lectureship"},{"name":"British Heart Foundation Clinical Research Training Fellowship","award":["FS\/17\/81\/33318"],"award-info":[{"award-number":["FS\/17\/81\/33318"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The importance of early life factors in determining health in later adulthood is increasingly recognized. This study evaluated the association of adverse childhood experiences (ACEs) with cardiovascular magnetic resonance (CMR) phenotypes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>UK Biobank participants who had completed CMR and the self-reported questionnaire on traumatic childhood experiences were included. Images were analysed using automated pipelines to extract measures of left and right ventricular (LV and RV) structure and function, myocardial character, and arterial compliance. Multivariable linear regression was used to estimate the association of childhood adversity with CMR phenotypes adjusting for age, sex, deprivation, education, obesity, smoking, alcohol intake, exercise level, diabetes, hypertension, and hypercholesterolaemia. Amongst 30 814 participants analysed, 6023 (19.5%) experienced physical abuse, 2746 (8.9%) sexual abuse, 4685 (15.2%) emotional abuse, 6822 (22.1%) emotional neglect, and 4534 (14.7%) physical neglect. Except for physical abuse, women reported greater rates of childhood adversity than men. Collectively, all types of childhood adversity were associated with smaller LV and RV volumes, greater LV mass, a concentric pattern of LV remodelling, poorer LV and RV function, lower aortic compliance, and greater arterial stiffness. Sexual abuse was associated with unhealthy CMR phenotypes in age- and sex-adjusted models, but these relationships were attenuated in fully adjusted models. Physical neglect had the most prominent pattern of adverse cardiovascular remodelling.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>ACEs were associated with unhealthy cardiovascular remodelling in adulthood, independent of traditional cardiovascular risk factors. These findings support the consideration of early life factors in cardiovascular disease risk assessment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyae139","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T11:10:23Z","timestamp":1734606623000},"source":"Crossref","is-referenced-by-count":4,"title":["The association between adverse childhood experiences and adult cardiac function in the UK Biobank"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0241-5376","authenticated-orcid":false,"given":"Juan C","family":"Quiroz","sequence":"first","affiliation":[{"name":"Centre for Big Data Research in Health (CBDRH), The University of New South Wales (UNSW) , Level 2, AGSM Building G27, Botany St, Kensington, NSW 2033 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Cooper","sequence":"additional","affiliation":[{"name":"William Harvey Research 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Bartholomew\u2019s Hospital, Barts Health NHS Trust , West Smithfield, London EC1A 7BE ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1020-3402","authenticated-orcid":false,"given":"Liliana","family":"Laranjo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, Westmead Applied Research Centre (WARC), Sydney Medical School, The University of Sydney , Westmead ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5095-1611","authenticated-orcid":false,"given":"Nay","family":"Aung","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ ,","place":["UK"]},{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, Barts Health NHS Trust , West Smithfield, London EC1A 7BE 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