{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:53:07Z","timestamp":1777931587695,"version":"3.51.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":133,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health-Ricerca Corrente"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Valve-in-Valve transcatheter aortic valve replacement (ViV-TAVR) is an appealing treatment option for patients with degenerated aortic bioprosthetic valves. However, higher post-procedural transprosthetic gradients are more common after ViV-TAVR than after TAVR for native aortic valve stenosis. We sought to evaluate the impact of type of implanted valve and balloon post-dilation on echocardiographic results and mortality in ViV-TAVR patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>One hundred and eleven consecutive patients were enrolled. A balloon-expandable valve, a self-expandable valve without balloon post-dilation, and a self-expandable valve with balloon post-dilation were performed in 35 (Group 1), 39 (Group 2), and 37 (Group 3) patients, respectively. All patients underwent comprehensive transthoracic echocardiography at baseline, discharge, and 6\u201312 months follow-up. Successful ViV-TAVR was performed in 110 patients (99%). Baseline transprosthetic gradients, left ventricular volumes, ejection fraction, and pulmonary artery systolic pressure were similar among groups. All groups experienced a significant reduction in post-procedural gradients at discharge and during the 6\u201312 months follow-up compared with baseline. At discharge, the lowest mean gradient was observed in Group 3 (12 \u00b1 7\u2005mmHg) compared with both Group 1 (20 \u00b1 9\u2005mmHg) and Group 2 (17 \u00b1 8\u2005mmHg, P = 0.001). This result was confirmed at 6\u201312 months follow-up (P = 0.012). Similar 5-year all-cause mortality was observed among groups (34%, 36%, 14%, respectively, P = 0.056).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with failed surgical aortic prosthesis, ViV-TAVR is an effective treatment option associated with sustained improved haemodynamics regardless of transcatheter valve type and use of balloon post-dilation. However, self-expandable valves with balloon post-dilation showed lower transprosthetic gradients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyaf048","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T09:49:22Z","timestamp":1747216162000},"source":"Crossref","is-referenced-by-count":2,"title":["Valve type and post-dilation impact on transprosthetic gradients in patients undergoing transcatheter aortic valve-in-valve procedure"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4200-1362","authenticated-orcid":false,"given":"Manuela","family":"Muratori","sequence":"first","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-6231","authenticated-orcid":false,"given":"Laura","family":"Fusini","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]},{"name":"Department of Electronics, Information and Biomedical Engineering, Politecnico di Milano , via Ponzio 34\/5, 20133 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2116-9644","authenticated-orcid":false,"given":"Gloria","family":"Tamborini","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1342-6820","authenticated-orcid":false,"given":"Paola","family":"Gripari","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7431-9343","authenticated-orcid":false,"given":"Sarah","family":"Ghulam Ali","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-1625","authenticated-orcid":false,"given":"Valentina","family":"Mantegazza","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]},{"name":"Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan , via della Commenda 19, 20122 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Garlasch\u00e8","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Doni","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]},{"name":"Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan , via della Commenda 19, 20122 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8261-4529","authenticated-orcid":false,"given":"Andrea","family":"Baggiano","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]},{"name":"Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan , via della Commenda 19, 20122 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cannata","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-2078","authenticated-orcid":false,"given":"Alberico","family":"Del Torto","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Fazzari","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8735-6932","authenticated-orcid":false,"given":"Antonio","family":"Frappampina","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via 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,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8479-122X","authenticated-orcid":false,"given":"Luigi","family":"Tassetti","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Volpe","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan 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20122 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio L","family":"Bartorelli","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, IRCCS Ospedale Galeazzi Sant'Ambrogio , via Belgioioso 173, 20157 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"De Marco","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2524-6288","authenticated-orcid":false,"given":"Mauro","family":"Pepi","sequence":"additional","affiliation":[{"name":"Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS , via Parea 4, 20138 Milan 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