{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T18:04:09Z","timestamp":1764353049186,"version":"3.46.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Non-invasive estimation of left ventricular pressure (LVP) is crucial for managing cardiovascular diseases such as heart failure and myocardial infarction (MI). Current clinical practices rely on invasive catheterization, limiting its feasibility for routine or longitudinal monitoring. This study evaluates the accuracy of a novel LVP reconstruction algorithm in preclinical (rat) experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Using a standard coronary occlusion\/reperfusion model (n = 39 rats), we validated our algorithm across three physiological states: baseline, myocardial ischaemia, and MI. LVP waveforms were reconstructed using only carotid pressure waveforms and echocardiographic measurements. Algorithm performance was assessed by comparing reconstructed LVP waveforms to invasively measured LVP, using key haemodynamic metrics such as left ventricular end-diastolic pressure (LVEDP) and the subendocardial viability ratio (SEVR). Agreements between waveforms were assessed using intraclass correlation coefficients (ICC), normalized Euclidean distance (NED), and differences in harmonic modulus. The algorithm accurately estimated LVEDP across all physiological states (mean absolute error: 1.5\u202fmmHg), with strong correlation to invasively measured LVEDPs (r\u202f=\u202f0.91). Predicted SEVR also showed strong agreement with measured values (r\u202f=\u202f0.96). The algorithm captured the expected LVEDP elevation and SEVR reduction during myocardial ischaemia, and the metric's partial recovery after reperfusion. Waveform-level agreement demonstrated near-perfect alignment, with high ICC (98.5%), low NED (0.062), and minimal harmonic modulus differences (0.043) for all tested cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that LVP can be accurately reconstructed using the proposed algorithm in rats. Our algorithm reliably captured key LVP metrics and waveform features across varying physiological states, supporting its potential for cardiac monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyaf136","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:12:21Z","timestamp":1761829941000},"source":"Crossref","is-referenced-by-count":0,"title":["A new hybrid echocardiography and arterial pressure waveform approach for non-invasive reconstruction of the entire left ventricular pressure waveform"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0231-4727","authenticated-orcid":false,"given":"Coskun","family":"Bilgi","sequence":"first","affiliation":[{"name":"Department of Aerospace and Mechanical Engineering, University of Southern California , Los Angeles, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1179-7089","authenticated-orcid":false,"given":"Rashid","family":"Alavi","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering, California Institute of Technology , Pasadena, CA ,","place":["USA"]},{"name":"Cardiovascular Research Institute, Huntington Medical Research Institutes , Pasadena, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Aerospace and Mechanical Engineering, University of Southern California , Los Angeles, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4797-0138","authenticated-orcid":false,"given":"Wangde","family":"Dai","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Huntington Medical Research Institutes , Pasadena, CA ,","place":["USA"]},{"name":"Division of Cardiovascular Medicine, Viterbi School of Engineering and Keck School of Medicine, University of Southern California , 1002 Childs Way, MCB 470, Los Angeles, CA 90089 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdallah","family":"Elkhal","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Huntington Medical Research Institutes , Pasadena, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray V","family":"Matthews","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Viterbi School of Engineering and Keck School of Medicine, University of Southern California , 1002 Childs Way, MCB 470, Los Angeles, CA 90089 ,","place":["USA"]},{"name":"Cardiac and Vascular Institute, University of Southern California , Los Angeles, CA 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