{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T03:19:52Z","timestamp":1767928792263,"version":"3.49.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Myocardial perfusion imaging (MPI) is used to evaluate ischaemia in patients with chronic total occlusion (CTO), but its prognostic implications following percutaneous coronary intervention (PCI) of CTO remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate outcomes in patients treated with CTO-PCI stratified by moderate\u2013severe ischaemia on MPI prior to intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients from the Western Danish Heart Registry assessed by nuclear MPI and subsequently treated with CTO-PCI \u2264 6 months were included. Moderate\u2013severe ischaemia was defined as \u226510% left ventricle involvement. Primary endpoints were all-cause mortality and a composite of major adverse cardio- and cerebrovascular events [MACCE; cardiovascular death, myocardial infarction (MI), stroke, and hospitalization for heart failure (HF) or angina pectoris]. Secondary endpoints included the individual MACCE components. Outcomes were compared between patients with and without moderate\u2013severe ischaemia using multivariable Cox regression and competing risk regression at 90-day and 5-year follow-ups. Among 319 patients, 208 (65.2%) had moderate\u2013severe ischaemia. All-cause mortality was similar between patients with and without moderate\u2013severe ischaemia [adjusted hazard ratio (aHR) 1.12, 95% confidence interval (CI): 0.52\u20132.43], P = 0.77). The estimated risk of MACCE was comparable between groups at 90 days [aHR 0.76 (0.38\u20131.55), P = 0.46] and 5 years [aHR 0.74 (0.45\u20131.20), P = 0.22]. No difference was found in MI [5 years: aHR 0.76 (0.26\u20132.22), P = 0.61] or hospitalization for HF [90 days: aHR 0.44 (0.16\u20131.21), P = 0.11]; 5 years: aHR 0.62 (0.30\u20131.30), P = 0.21]. Hospitalization for angina was similar at 90 days [aHR 0.75 (0.26\u20132.16), P = 0.60], but a decreased 5-year risk was observed in patients with moderate\u2013severe ischaemia [aHR 0.46 (0.23\u20130.91), P = 0.026].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Moderate\u2013severe ischaemia on nuclear MPI was not associated with differences in mortality or MACCE after CTO-PCI but was associated with a lower long-term risk of angina hospitalization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyaf137","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T12:46:05Z","timestamp":1761655565000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of myocardial perfusion abnormalities on clinical outcomes in patients treated with percutaneous coronary intervention for chronic total occlusions"],"prefix":"10.1093","volume":"4","author":[{"given":"Jesper Boes","family":"Henningsen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital , Hobrovej 18-20, Aalborg 9000 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc Meller","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital , Hobrovej 18-20, Aalborg 9000 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen Hyldgaard","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital , Hobrovej 18-20, Aalborg 9000 ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-5600","authenticated-orcid":false,"given":"Jacob 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