{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:31:06Z","timestamp":1767339066897,"version":"3.46.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"publisher","award":["CS-2018\u201318-ST2-007","RP-2017-08-ST2-007"],"award-info":[{"award-number":["CS-2018\u201318-ST2-007","RP-2017-08-ST2-007"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In the assessment of myocardial ischaemia, vasoactive breathing manoeuvres have been proposed as a potential alternative to pharmacological vasodilator stress. However, it remains unclear whether the resultant physiological responses are comparable to those induced by adenosine in patients with suspected coronary artery disease (CAD). We sought to compare the myocardial oxygenation responses to a hyperventilation breath-hold (HVBH) manoeuvre with those elicited by adenosine, using oxygenation-sensitive cardiovascular magnetic resonance (OS-CMR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients with suspected angina underwent 3-Tesla OS-CMR with (i) HVBH and (ii) adenosine (140\u2013210\u2005\u03bcg\/kg\/min) prior to invasive coronary angiography. The primary outcome was the maximal percentage change in OS-CMR signal intensity for (i) HVBH [breathing-induced myocardial oxygenation reserve (B-MOREmax)] and (ii) adenosine [adenosine-induced myocardial oxygenation reserve (A-MORE)]. Significant CAD was defined as fractional flow reserve \u22640.80 in epicardial vessels \u22652\u2005mm diameter. From 53 prospectively recruited patients, 44 had complete, paired OS-CMR sequences (mean age 69 \u00b1 9 years, 75% male, CAD prevalence 59%). The HVBH manoeuvre elicited a myocardial oxygenation response comparable to that of adenosine (B-MOREmax 7.0 \u00b1 9.5% vs. A-MORE 8.6 \u00b1 12.3%, mean difference: \u22121.6% [\u22126.0%, 2.8%]; P = 0.469), which remained similar at the segmental level following adjustment for age, sex, cardiovascular comorbidities, CAD, and infarction (mean difference: \u22121.7% [\u22124.0%, 0.5%]; P = 0.126).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with suspected CAD, HVBH induces a myocardial oxygenation response comparable to that elicited by adenosine. Future prospective studies evaluating the diagnostic accuracy of OS-CMR combined with vasoactive breathing manoeuvres for detecting significant CAD are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyaf141","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:05:15Z","timestamp":1762952715000},"source":"Crossref","is-referenced-by-count":1,"title":["Vasoactive breathing manoeuvres as an effective coronary vasodilator in patients with suspected coronary artery disease: a prospective comparative oxygenation-sensitive CMR study"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4761-7297","authenticated-orcid":false,"given":"Simran","family":"Shergill","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester LE3 9QP ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Hillier","sequence":"additional","affiliation":[{"name":"Department of Medicine, McGill University Health Centre , 3605 de la Montagne, Montreal, QC H3G 2M1 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju","family":"Velvet","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester LE3 9QP ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charley A","family":"Budgeon","sequence":"additional","affiliation":[{"name":"Cardiovascular Epidemiology Research Centre, School of Population and Global Health, University of Western Australia , 35 Stirling Highway, Crawley 6009 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Moafi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester LE3 9QP ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8555-5141","authenticated-orcid":false,"given":"Mohamed","family":"Elshibly","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester LE3 9QP ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"England","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester LE3 9QP ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly S","family":"Parke","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester LE3 9QP ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne V","family":"Wormleighton","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester LE3 9QP ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Adlam","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester LE3 9QP ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep S","family":"Hothi","sequence":"additional","affiliation":[{"name":"Heart and Lung Centre, Royal Wolverhampton NHS Trust , Wolverhampton Road, Wolverhampton WV10 0QP ,","place":["UK"]},{"name":"Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham , Edgbaston, Birmingham B15 2TT ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-0594","authenticated-orcid":false,"given":"Andrew","family":"Ladwiniec","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester LE3 9QP ,","place":["UK"]},{"name":"Department of Cardiology, University Hospitals of Leicester NHS Trust , Glenfield Hospital, Groby Road, Leicester LE3 9QP ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias G","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Medicine, McGill University Health Centre , 3605 de la Montagne, Montreal, QC H3G 2M1 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerry P","family":"McCann","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester LE3 9QP ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Ranjit","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, the National Institute for Health and Care Research Leicester Biomedical Research Centre and British Heart Foundation Centre of Research Excellence, Glenfield Hospital , Groby Road, Leicester LE3 9QP ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"2025120512481230700_qyaf141-B1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/eurheartj\/ehm617","article-title":"MR-IMPACT: comparison of perfusion-cardiac magnetic resonance with single-photon emission computed tomography for the detection of coronary artery disease in a multicentre, multivendor, randomized trial","volume":"29","author":"Schwitter","year":"2008","journal-title":"Eur Heart J"},{"key":"2025120512481230700_qyaf141-B2","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/CIRCULATIONAHA.109.907659","article-title":"Incremental prognostic significance of combined cardiac magnetic resonance imaging, adenosine stress perfusion, delayed enhancement, and left ventricular function over preimaging information for the prediction of adverse events","volume":"123","author":"Bingham","year":"2011","journal-title":"Circulation"},{"key":"2025120512481230700_qyaf141-B3","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(11)61335-4","article-title":"Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease (CE-MARC): a prospective trial","volume":"379","author":"Greenwood","year":"2012","journal-title":"Lancet"},{"key":"2025120512481230700_qyaf141-B4","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1001\/jama.2016.12680","article-title":"Effect of care guided by cardiovascular magnetic resonance, myocardial perfusion scintigraphy, or NICE guidelines on subsequent unnecessary angiography rates: the CE-MARC 2 randomized clinical trial","volume":"316","author":"Greenwood","year":"2016","journal-title":"JAMA"},{"key":"2025120512481230700_qyaf141-B5","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1056\/NEJMoa1716734","article-title":"Magnetic resonance perfusion or fractional flow reserve in coronary disease","volume":"380","author":"Nagel","year":"2019","journal-title":"N Engl J Med"},{"key":"2025120512481230700_qyaf141-B6","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1001\/jamacardio.2023.1290","article-title":"Diagnostic and prognostic value of stress cardiovascular magnetic resonance imaging in patients with known or suspected coronary artery disease: a systematic review and meta-analysis","volume":"8","author":"Ricci","year":"2023","journal-title":"JAMA Cardiol"},{"key":"2025120512481230700_qyaf141-B7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10554-008-9392-3","article-title":"Tolerance and safety of adenosine stress perfusion cardiovascular magnetic resonance imaging in patients with severe coronary artery disease","volume":"25","author":"Karamitsos","year":"2009","journal-title":"Int J Cardiovasc Imaging"},{"key":"2025120512481230700_qyaf141-B8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1148\/radiol.2015142690","article-title":"Gadolinium-based contrast agent accumulates in the brain even in subjects without severe renal dysfunction: evaluation of autopsy brain specimens with inductively coupled plasma mass spectroscopy","volume":"276","author":"Kanda","year":"2015","journal-title":"Radiology"},{"key":"2025120512481230700_qyaf141-B9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1073\/pnas.22.4.210","article-title":"The magnetic properties and structure of hemoglobin, oxyhemoglobin and carbonmonoxyhemoglobin","volume":"22","author":"Pauling","year":"1936","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025120512481230700_qyaf141-B10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/mrm.1910140108","article-title":"Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields","volume":"14","author":"Ogawa","year":"1990","journal-title":"Magn Reson Med"},{"key":"2025120512481230700_qyaf141-B11","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/jcbfm.2012.23","article-title":"Biophysical and physiological origins of blood oxygenation level-dependent fMRI signals","volume":"32","author":"Kim","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"2025120512481230700_qyaf141-B12","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1161\/01.CIR.0000095271.08248.EA","article-title":"Blood oxygen level\u2013dependent magnetic resonance imaging in patients with stress-induced angina","volume":"108","author":"Friedrich","year":"2003","journal-title":"Circulation"},{"key":"2025120512481230700_qyaf141-B13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jcmg.2009.12.008","article-title":"Navigator-gated 3D blood oxygen level\u2013dependent CMR at 3.0-T for detection of stress-induced myocardial ischemic reactions","volume":"3","author":"Jahnke","year":"2010","journal-title":"JACC Cardiovasc Imaging"},{"key":"2025120512481230700_qyaf141-B14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1532-429X-12-54","article-title":"BOLD cardiovascular magnetic resonance at 3.0 tesla in myocardial ischemia","volume":"12","author":"Manka","year":"2010","journal-title":"J Cardiovasc Magn Reson"},{"key":"2025120512481230700_qyaf141-B15","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.jacc.2012.01.055","article-title":"Myocardial oxygenation in coronary artery disease: insights from blood oxygen level\u2013dependent magnetic resonance imaging at 3 Tesla","volume":"59","author":"Arnold","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2025120512481230700_qyaf141-B16","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1093\/ehjci\/jeu138","article-title":"Relationship of vasodilator-induced changes in myocardial oxygenation with the severity of coronary artery stenosis: a study using oxygenation-sensitive cardiovascular magnetic resonance","volume":"15","author":"Luu","year":"2014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2025120512481230700_qyaf141-B17","doi-asserted-by":"crossref","first-page":"H1678","DOI":"10.1152\/ajpheart.00281.2011","article-title":"Cerebral and myocardial blood flow responses to hypercapnia and hypoxia in humans","volume":"301","author":"Beaudin","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2025120512481230700_qyaf141-B18","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2967\/jnumed.116.185991","article-title":"Arterial CO2 as a potent coronary vasodilator: a preclinical PET\/MR validation study with implications for cardiac stress testing","volume":"58","author":"Yang","year":"2017","journal-title":"J Nucl Med"},{"key":"2025120512481230700_qyaf141-B19","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/ehjci\/jet171","article-title":"Breathing manoeuvre-dependent changes in myocardial oxygenation in healthy humans","volume":"15","author":"Guensch","year":"2014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2025120512481230700_qyaf141-B20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/ehjci\/jeu202","article-title":"Response of myocardial oxygenation to breathing manoeuvres and adenosine infusion","volume":"16","author":"Fischer","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2025120512481230700_qyaf141-B21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12968-023-00983-4","article-title":"The reproducibility of breathing maneuvers as a vasoactive stimulus in the heart: an oxygenation-sensitive resonance imaging study","volume":"25","author":"Hillier","year":"2023","journal-title":"J Cardiovasc Magn Reson"},{"key":"2025120512481230700_qyaf141-B22","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jjcc.2016.03.011","article-title":"Impact of hyperventilation and apnea on myocardial oxygenation in patients with obstructive sleep apnea\u2014an oxygenation-sensitive CMR study","volume":"69","author":"Roubille","year":"2017","journal-title":"J Cardiol"},{"key":"2025120512481230700_qyaf141-B23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12968-018-0446-y","article-title":"Feasibility of cardiovascular magnetic resonance to detect oxygenation deficits in patients with multi-vessel coronary artery disease triggered by breathing maneuvers","volume":"20","author":"Fischer","year":"2018","journal-title":"J Cardiovasc Magn Reson"},{"key":"2025120512481230700_qyaf141-B24","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1097\/TP.0000000000003419","article-title":"Myocardial vascular function assessed by dynamic oxygenation-sensitive cardiac magnetic resonance imaging long-term following cardiac transplantation","volume":"105","author":"Iannino","year":"2021","journal-title":"Transplantation"},{"key":"2025120512481230700_qyaf141-B25","first-page":"e008903","article-title":"Insights into myocardial oxygenation and cardiovascular magnetic resonance tissue biomarkers in heart failure with preserved ejection fraction","volume":"15","author":"Fischer","year":"2022","journal-title":"Circulation"},{"key":"2025120512481230700_qyaf141-B26","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/ehjci\/jeae076","article-title":"Heterogeneity of coronary vascular function and myocardial oxygenation in women with angina and non-obstructive coronary artery disease","volume":"25","author":"Hillier","year":"2024","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2025120512481230700_qyaf141-B27","doi-asserted-by":"crossref","first-page":"101939","DOI":"10.1016\/j.jocmr.2025.101939","article-title":"CMR versus CCTA with fractional flow reserve for diagnosing obstructive coronary artery disease in higher risk patients: rationale and design of CONCORD\u2014a prospective, single-centre diagnostic accuracy study","author":"Shergill","year":"2025","journal-title":"J Cardiovasc Magn Reson"},{"key":"2025120512481230700_qyaf141-B28","doi-asserted-by":"crossref","first-page":"qyaf042","DOI":"10.1093\/ehjimp\/qyaf042","article-title":"Standard breath-hold versus free-breathing real-time cine cardiac MRI\u2014a prospective randomized comparison in patients with known or suspected cardiac disease","volume":"3","author":"Elshibly","year":"2025","journal-title":"Eur Heart J Imaging Methods Pract"},{"key":"2025120512481230700_qyaf141-B29","first-page":"e64149","article-title":"Oxygenation-sensitive cardiac MRI with vasoactive breathing maneuvers for the non-invasive assessment of coronary microvascular dysfunction","volume":"186","author":"Hillier","year":"2022","journal-title":"J Vis Exp"},{"key":"2025120512481230700_qyaf141-B30","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12968-020-00607-1","article-title":"Standardized cardiovascular magnetic resonance imaging (CMR) protocols: 2020 update","volume":"22","author":"Kramer","year":"2020","journal-title":"J Cardiovasc Magn Reson"},{"key":"2025120512481230700_qyaf141-B31","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"2025120512481230700_qyaf141-B32","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.jacc.2004.09.020","article-title":"Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model","volume":"44","author":"Amado","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2025120512481230700_qyaf141-B33","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/CIRCINTERVENTIONS.112.968511","article-title":"Coronary pressure\u2013derived fractional flow reserve measurements: recommendations for standardization, recording, and reporting as a Core Laboratory Technique. Proposals for integration in clinical trials","volume":"5","author":"Vranckx","year":"2012","journal-title":"Circ Cardiovasc Interv"},{"key":"2025120512481230700_qyaf141-B34","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC guidelines for the management of chronic coronary syndromes: developed by the task force for the management of chronic coronary syndromes of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur Heart J"},{"key":"2025120512481230700_qyaf141-B35","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.jcmg.2025.05.009","article-title":"Quantitative flow ratio for detecting significant coronary artery disease: validation by cardiovascular magnetic resonance","volume":"18","author":"Shergill","year":"2025","journal-title":"JACC Cardiovasc Imaging"},{"key":"2025120512481230700_qyaf141-B36","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1093\/ehjci\/jey202","article-title":"Cardiovascular risk is associated with a transmural gradient of myocardial oxygenation during adenosine infusion","volume":"20","author":"Luu","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2025120512481230700_qyaf141-B37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1532-429X-15-43","article-title":"Oxygenation-sensitive cardiovascular magnetic resonance","volume":"15","author":"Friedrich","year":"2013","journal-title":"J Cardiovasc Magn Reson"},{"key":"2025120512481230700_qyaf141-B38","doi-asserted-by":"crossref","first-page":"800720","DOI":"10.3389\/fcvm.2022.800720","article-title":"Combined analysis of myocardial deformation and oxygenation detects inducible ischemia unmasked by breathing maneuvers in chronic coronary syndrome","volume":"9","author":"Spicher","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"2025120512481230700_qyaf141-B39","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s12265-023-10474-7","article-title":"Automated data transformation and feature extraction for oxygenation-sensitive cardiovascular magnetic resonance images","volume":"17","author":"Plasa","year":"2024","journal-title":"J Cardiovasc Transl Res"},{"key":"2025120512481230700_qyaf141-B40","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0735-1097(23)01851-X","article-title":"Machine learning based analysis of oxygenation-sensitive CMR images in patients with suspected coronary artery stenosis","volume":"81","author":"Plasa","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"2025120512481230700_qyaf141-B41","doi-asserted-by":"crossref","first-page":"e0210098","DOI":"10.1371\/journal.pone.0210098","article-title":"Relationship between myocardial oxygenation and blood pressure: experimental validation using oxygenation-sensitive cardiovascular magnetic resonance","volume":"14","author":"Guensch","year":"2019","journal-title":"PLoS One"},{"key":"2025120512481230700_qyaf141-B42","doi-asserted-by":"crossref","first-page":"qyae127","DOI":"10.1093\/ehjimp\/qyae127","article-title":"Haemodynamic and hyperaemic effects of adenosine in patients with atrial fibrillation undergoing quantitative myocardial perfusion cardiovascular magnetic resonance","volume":"2","author":"Shergill","year":"2024","journal-title":"Eur Heart J Imaging Methods Pract"},{"key":"2025120512481230700_qyaf141-B43","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12968-016-0262-1","article-title":"The impact of hematocrit on oxygenation-sensitive cardiovascular magnetic resonance","volume":"18","author":"Guensch","year":"2016","journal-title":"J Cardiovasc Magn Reson"}],"container-title":["European Heart Journal - Imaging Methods and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjimp\/advance-article-pdf\/doi\/10.1093\/ehjimp\/qyaf141\/65282223\/qyaf141.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjimp\/article-pdf\/3\/4\/qyaf141\/65282223\/qyaf141.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjimp\/article-pdf\/3\/4\/qyaf141\/65282223\/qyaf141.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T17:48:25Z","timestamp":1764956905000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjimp\/article\/doi\/10.1093\/ehjimp\/qyaf141\/8322297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10,6]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjimp\/qyaf141","relation":{},"ISSN":["2755-9637"],"issn-type":[{"type":"electronic","value":"2755-9637"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,10]]},"article-number":"qyaf141"}}