{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:38:01Z","timestamp":1787855881914,"version":"build-2784847793"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"BW","award":["R01HL180937"],"award-info":[{"award-number":["R01HL180937"]}]},{"name":"BW","award":["UL1TR002544"],"award-info":[{"award-number":["UL1TR002544"]}]},{"DOI":"10.13039\/100014180","name":"MH","doi-asserted-by":"publisher","award":["R01HL180937"],"award-info":[{"award-number":["R01HL180937"]}],"id":[{"id":"10.13039\/100014180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cardiac myosin inhibitors (CMIs) have revolutionized care for patients with obstructive hypertrophic cardiomyopathy (HCM), however they are associated with a risk of systolic dysfunction. Machine learning algorithms might expand access to frequent accurate assessment of left ventricular ejection fraction (LVEF). We assess the performance of a commercial ML-based LVEF model for patients with HCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Single centre prospective study of measurements of left ventricular function by Philips HeartModel\u00ae (automated) assessment, echocardiographer assessment (standard), and cardiac magnetic resonance imaging for patients with HCM. Assessments of LVEF, end diastolic volume and end systolic volume were studied across methods. 50 patients with HCM were included. Median age 64 years; 64% male; and 62% had cMRI data for analysis. Median automated LVEF was lower than standard [55.5% (IQR 9) vs. 62.5% (IQR 10), P 0.002, median difference\u20148% (IQR 14)] and cMRI assessment [55.5% (IQR 9) vs. 68% (IQR 9.5), P &amp;lt; 0.001, median difference\u201412% (IQR 16)]. Automated assessment traced larger EDVs and ESVs compared with standard 2D tracings [141\u2005mL (IQR 66) vs. 114\u2005mL (IQR 55), P 0.001, and 64\u2005mL (IQR 35) vs. 41\u2005mL (IQR 25), P &amp;lt; 0.001]. Automated assessment identified 11 (22%) patients as having LVEF &amp;lt; 50% vs. 6 (12%) patients identified by expert imaging assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For patients with HCM, automated assessments of LV size and function differ significantly from standard assessments, raising concerns about the use of this ML-enabled LVEF software for this patient population and potential application to guiding CMI treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyag003","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:41:40Z","timestamp":1767789700000},"source":"Crossref","is-referenced-by-count":2,"title":["Assessment of HeartModel\u00ae automated left ventricular ejection fraction for patients with hypertrophic cardiomyopathy"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0432-7468","authenticated-orcid":false,"given":"John","family":"Morrissey","sequence":"first","affiliation":[{"name":"Department of Medicine, Tufts Medical Center , Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libin","family":"Wang","sequence":"additional","affiliation":[{"name":"CardioVascular Center, Tufts Medical Center , 800 Washington Street, Box 63, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Dehn","sequence":"additional","affiliation":[{"name":"CardioVascular Center, Tufts Medical Center , 800 Washington Street, Box 63, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayan R","family":"Patel","sequence":"additional","affiliation":[{"name":"CardioVascular Center, Tufts Medical Center , 800 Washington Street, Box 63, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsalan","family":"Rafiq","sequence":"additional","affiliation":[{"name":"CardioVascular Center, Tufts Medical Center , 800 Washington Street, Box 63, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavi","family":"Kadiyala","sequence":"additional","affiliation":[{"name":"CardioVascular Center, Tufts Medical Center , 800 Washington Street, Box 63, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Tufts University, Medford, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Rowin","sequence":"additional","affiliation":[{"name":"Hypertrophic Cardiomyopathy Center at Lahey Hospital and Medical Center , Burlington, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Maron","sequence":"additional","affiliation":[{"name":"Hypertrophic Cardiomyopathy Center at Lahey Hospital and Medical Center , Burlington, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-1426","authenticated-orcid":false,"given":"Benjamin S","family":"Wessler","sequence":"additional","affiliation":[{"name":"CardioVascular Center, Tufts Medical Center , 800 Washington Street, Box 63, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"2026012812425853400_qyag003-B1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijcard.2023.04.005","article-title":"How common is hypertrophic cardiomyopathy\u2026 really?: disease prevalence revisited 27 years after 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