{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T04:53:12Z","timestamp":1772599992881,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":202,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Obtaining images of diagnostic quality using coronary CT angiography (CCTA) depends, in part, upon a patient\u2019s heart rate (HR) at time of scanning. HR reduction is most commonly achieved with beta blockers. In the paediatric population, the effectiveness of beta blockers is limited by hypotensive effects. Phenylephrine, a pure alpha agonist, raises blood pressure and causes reflex bradycardia so it could be used to reduce patients\u2019 HRs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and\u00a0results<\/jats:title>\n                    <jats:p>We retrospectively reviewed all children at a single centre who underwent sedated CCTA study using phenylephrine between 2019 and 2024. In 25 children (mean age 5.3 \u00b1 2.5 years), HR was reduced from a mean of 94.1 to 73.8 beats per minute (bpm). No adverse effects were reported. Images of diagnostic quality were obtained in all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this first-of-its-kind study we found that phenylephrine was effective at reducing patients\u2019 HRs prior to CCTA, with an average reduction of 20 bpm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyag023","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T12:49:59Z","timestamp":1770209399000},"source":"Crossref","is-referenced-by-count":0,"title":["Heart rate control in paediatric coronary CT angiography using phenylephrine"],"prefix":"10.1093","volume":"3","author":[{"given":"Yosef A","family":"Cohen","sequence":"first","affiliation":[{"name":"Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and NewYork-Presbyterian Hospital , 622 West 168th Street PH 10-203, New York, NY 10032 ,","place":["USA"]},{"name":"Department of Pediatrics, Children\u2019s Hospital at Montefiore , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bremner","sequence":"additional","affiliation":[{"name":"Vagelos College of Physicians and Surgeons , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrinali","family":"Shetty","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Louisville , Louisville, KY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charissa J","family":"Chou","sequence":"additional","affiliation":[{"name":"Vagelos College of Physicians and Surgeons , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Castillo","sequence":"additional","affiliation":[{"name":"Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and NewYork-Presbyterian Hospital , 622 West 168th Street PH 10-203, New York, NY 10032 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Chernovolenko","sequence":"additional","affiliation":[{"name":"Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and NewYork-Presbyterian Hospital , 622 West 168th Street PH 10-203, New York, NY 10032 ,","place":["USA"]},{"name":"Department of Radiology, Columbia University Irving Medical Center and NewYork-Presbyterian Hospital , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanwal M","family":"Farooqi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Columbia University Irving Medical Center and NewYork-Presbyterian Morgan Stanley Children's Hospital , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amee M","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Columbia University Irving Medical Center and NewYork-Presbyterian Morgan Stanley Children's Hospital , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Chelliah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Columbia University Irving Medical Center and NewYork-Presbyterian Morgan Stanley Children's Hospital , New York, NY ,","place":["USA"]},{"name":"Division of Cardiology, Department of Pediatrics, Goryeb Children's Hospital, Atlantic Health System , Morristown, NJ ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2583-9278","authenticated-orcid":false,"given":"Andrew J","family":"Einstein","sequence":"additional","affiliation":[{"name":"Seymour, Paul and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and NewYork-Presbyterian Hospital , 622 West 168th Street PH 10-203, New York, NY 10032 ,","place":["USA"]},{"name":"Department of Radiology, Columbia University Irving Medical Center and NewYork-Presbyterian Hospital , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"2026030322545979500_qyag023-B1","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1007\/s00247-010-1711-x","article-title":"Safety and efficacy of a drug regimen to control heart rate during 64-slice ECG-gated coronary CTA in children","volume":"40","author":"Rigsby","year":"2010","journal-title":"Pediatr 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