{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:46:48Z","timestamp":1781866008743,"version":"3.54.5"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":67,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bern University Hospital Department of Anaesthesiology and Pain Medicine scientific"},{"name":"European Society of Anaesthesiology and Intensive Care","award":["ESAIC_GR_2019_KF"],"award-info":[{"award-number":["ESAIC_GR_2019_KF"]}]},{"name":"European Society of Anaesthesiology and Intensive Care","award":["ESAIC_GR_2019_DG"],"award-info":[{"award-number":["ESAIC_GR_2019_DG"]}]},{"name":"Swiss National Scientific Funds","award":["32003B_212536"],"award-info":[{"award-number":["32003B_212536"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cardiovascular magnetic resonance (CMR) imaging is a key modality for characterizing heart diseases, but is limited in assessing diastolic dysfunction (DD). 4D flow CMR now enables transvalvular blood flow quantification, while biventricular tissue relaxation can be quantified through annular tissue velocity and strain on standard cine images. This study investigated the utility of 4D-CMR-derived E\/e\u2032 in evaluating biventricular diastolic function. Secondary aims included comparison with echocardiography to establish 4D-E\/e\u2032 cutoffs for detecting unknown DD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Diastolic transvalvular flow (4D-E) was quantified from 4D flow in 75 controls and 57 patients with cardiovascular disease. Tissue velocity (e\u2032) was assessed using cine-derived mitral\/tricuspid annular velocity, longitudinal strain rate (e\u2032FT-SR), and strain velocity (e\u2032FT-vel). Biventricular 4D-E\/e\u2032 was feasible across all e\u2032 methods, and significantly higher in patients than controls (P &amp;lt; 0.05). The patients were split into two subgroups: one with echocardiographic graded DD to derive CMR cutoffs, and a second with unassessed diastolic function. 4D-E\/e\u2032 using annular velocity best distinguished patients with echocardiography-confirmed DD in the left (AUC = 0.90 \u00b1 0.05, P &amp;lt; 0.01) and right heart (AUC = 0.81 \u00b1 0.07, P &amp;lt; 0.01). Among patients without a diastolic assessment, 71% were identified with abnormal left ventricular diastolic function and 61% with abnormal right ventricular diastolic function when stratified against the lower 4D-E\/e\u2019 cutoffs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>4D-E\/e\u2032, integrating transvalvular flow and tissue velocity, is feasible for biventricular diastolic function assessment. CMR identified previously unrecognized biventricular diastolic abnormalities in patients with cardiovascular disease, suggesting 4D-E\/e\u2032 may be a valuable tool for early detection and referral for further diastolic testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyag039","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T12:41:29Z","timestamp":1772196089000},"source":"Crossref","is-referenced-by-count":1,"title":["Evaluating biventricular diastolic function using cardiovascular magnetic resonance 4d-flow derived E\/e\u2019"],"prefix":"10.1093","volume":"4","author":[{"given":"Leonard","family":"Grob","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern , Freiburgstrasse 10, Bern 3010 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Tengg-Kobligk","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern , Bern ,","place":["Switzerland"]},{"name":"Translation Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Boscolo Berto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0032-0181","authenticated-orcid":false,"given":"Matthias","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern , Bern 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