{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:53:21Z","timestamp":1777049601977,"version":"3.51.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":95,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019147","name":"University Medical Center G\u00f6ttingen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Transcatheter aortic valve replacement (TAVR) is an established therapy improving outcome in patients with severe aortic stenosis (AS). Cardiovascular magnetic resonance (CMR)-derived left atrioventricular coupling index (LACI) has demonstrated prognostic value, however, its prognostic utility in severe AS remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Between January 2017 and September 2023 138 consecutive patients with severe AS (80 years (70\u201383), 62% male) referred for TAVR were prospectively recruited for pre-procedural CMR imaging. LACI was defined as the ratio of the left atrial (LA) end-diastolic volume index (LA EDVi) and left ventricular (LV) end-diastolic volume index (LV EDVi). The primary endpoint was cardiovascular (CV)-mortality. The cohort was dichotomized at a median of 44.1% (high vs. low LACI). Patients with increased LACI (\u226544.1%) had higher symptom burden (NYHA III\/IV prevalence (68.1% vs. 44.9%; P = 0.047)), more frequently atrial fibrillation (50.7% vs. 14.5%; P &amp;lt; 0.001), and elevated NT-proBNP (2017\u2005ng\/L vs. 1012\u2005ng\/L; P = 0.007). Over a median follow-up of 2.7 years (IQR 1.7\u20133.6), high LACI was associated with higher CV mortality (log-rank P = 0.016). In exploratory multivariable Cox regression models, LACI remained associated with CV-mortality after adjustment for established parameters of left atrial or ventricular function (LA reservoir strain: HR 2.19, 95% CI 1.05\u20134.57, P = 0.036; LV GLS: HR 2.21 95% CI 1.00\u20134.9, P = 0.049).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with severe aortic stenosis, CMR-derived LACI was associated with cardiovascular mortality and may serve as a structural marker of advanced atrioventricular remodelling. Given its simplicity and routine availability in standard CMR workflows, LACI may serve as a clinically practical risk marker for baseline stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyag061","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:52:39Z","timestamp":1775217159000},"source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of cardiovascular magnetic resonance-derived left atrioventricular coupling Index in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7737-9720","authenticated-orcid":false,"given":"Svante","family":"Gersch","sequence":"first","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen , G\u00f6ttingen ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site 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