{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:07:40Z","timestamp":1784581660777,"version":"3.55.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Centre"},{"DOI":"10.13039\/501100009234","name":"Central Hospital Kristianstad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009234","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Southern Healthcare Region of Sweden"},{"name":"Swedish Society of Pulmonary Arterial Hypertension"},{"name":"Heart-Lung Foundation"},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish governmental funding of clinical research"},{"DOI":"10.13039\/501100007687","name":"Swedish Society of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoord Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011077","name":"Sk\u00e5ne University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lund University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Right ventricular (RV) failure is a key determinant of outcome in precapillary pulmonary hypertension (PHprecap). Contemporary four-strata risk assessment incorporates functional capacity and NT-proBNP, yet the relationship between these and RV function remains unclear. We therefore examined these associations in PHprecap.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients with PHprecap [n = 49; 69% women, median age 62 (IQR 52,74) years] underwent 6-min walk distance (6MWD), NT-proBNP sampling, right heart catheterization, and comprehensive RV assessment by echocardiography and cardiac magnetic resonance imaging (CMR) most within 24\u2005h. RV function was impaired (RVEFCMR 41%, FWSECHO 15%, and FACECHO 30%), 6MWD was reduced (315\u2005m), and NT-proBNP was elevated (1078\u2005ng\/L). In multivariable analysis adjusted for age and sex, 6MWD was associated with RV longitudinal function parameters (adjusted R2 = 0.33\u20130.50, all P &amp;lt; 0.05), including FWS (B = \u221215.2, 95% CI \u221222.3 to \u22128; P &amp;lt; 0.001) and TAPSE\/sPAP (B = 338.6, 95% CI 179.7\u2013498.7; P &amp;lt; 0.001). In univariable analysis, log10(NT-proBNP) was associated with TAPSE, RV\u2013PA coupling parameters, AVPD, and CMR-derived FWS (all P &amp;lt; 0.05), but only TAPSE\/sPAP, S\u2019\/sPAP, and CMR\u2013FWS remained significant after adjustment for mean right atrial pressure. Combined models showed minimal incremental explanatory value of RV function for 6MWD, whereas AVPD and age were the only independent predictors (adjusted R2 \u2248 0.50).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Impaired RV longitudinal function is significantly associated with exercise capacity independent of imaging modality and confounders, whereas NT-proBNP provides a moderate reflection of right-sided filling pressures. Resting RV assessment may underestimate disease severity, and stress-based evaluation could better capture functional impairment in PHprecap.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyag116","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:40:44Z","timestamp":1782214844000},"source":"Crossref","is-referenced-by-count":0,"title":["Right ventricular longitudinal function is associated with exercise capacity in pre-capillary pulmonary hypertension: a multimodality imaging study"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6361-4582","authenticated-orcid":false,"given":"Raluca","family":"Jumatate","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Lund, Cardiology, and Section for Heart Failure and Valvular Disease, Lund University, Skane University Hospital ,","place":["Sweden"]},{"name":"Section for Internal Medicine and Cardiology, Central Hospital , JA Hedlunds v\u00e4g 5, Kristianstad 291 33 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Labaf","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund, Cardiology, and Section for Heart Failure and Valvular Disease, Lund University, Skane University Hospital ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Ingvarsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund, Cardiology, and Section for Heart Failure and Valvular Disease, Lund University, Skane University Hospital ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund, Clinical Physiology, Lund University, Skane University Hospital , Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2655-2423","authenticated-orcid":false,"given":"Ellen","family":"Ostenfeld","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund, Clinical Physiology, Lund University, Skane University Hospital , Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Werther-Evaldsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund, Cardiology, and Section for Heart Failure and Valvular Disease, Lund University, Skane University Hospital ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"2026072016562455900_qyag116-B1","doi-asserted-by":"crossref","first-page":"2401323","DOI":"10.1183\/13993003.01323-2024","article-title":"Risk stratification and treatment goals in pulmonary arterial hypertension","volume":"64","author":"Dardi","year":"2024","journal-title":"Eur Respir J"},{"key":"2026072016562455900_qyag116-B2","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: developed by the task force for the diagnosis and treatment of pulmonary hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). 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