{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T19:05:27Z","timestamp":1784142327562,"version":"3.55.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"publisher","award":["20241233"],"award-info":[{"award-number":["20241233"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Left ventricular (LV) hypertrophy is associated with adverse cardiac outcomes. LV mass index (LVMi) and interventricular septal wall thickness (WT) can be derived from 15O-water positron emission tomography (PET), but their prognostic value is unknown. We aimed to assess the prognostic value and test\u2013retest repeatability of PET-derived LV hypertrophy metrics in patients evaluated for suspected coronary artery disease (CAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We retrospectively included 783 consecutive patients referred for rest-stress PET. LVMi and WT were determined on non-ECG-gated resting 15O-water PET scans. Subjects were stratified by previous heart failure (HF) diagnosis and patients with known hypertrophic\/infiltrative cardiomyopathy were excluded. The primary outcome was major adverse cardiac events (MACE: cardiovascular death or acute HF). The prognostic value of LV hypertrophy measurements was evaluated using Cox hazard ratios (HR [95% confidence interval]). Test\u2013retest repeatability was evaluated in prospective data from 21 patients with repeated PET scans.<\/jats:p>\n                    <jats:p>Patients with known HF but no hypertrophic\/infiltrative cardiomyopathy (18%) had significantly higher LVMi (P &amp;lt; 0.0001) and WT (P = 0.0015) compared to subjects without HF (82%). Among patients without HF, 30 experienced MACE during a median 3.8 year follow up. Both LVMi (HR 1.04 [1.02\u20131.06] per g\/m2, P &amp;lt; 0.0001) and WT (HR 1.36 [1.10\u20131.68] per mm, P = 0.0045) independently predicted MACE after adjustment for sex, age and myocardial flow reserve. Test\u2013retest repeatability was high, with no significant bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PET LV hypertrophy metrics can be robustly quantified from routine 15O-water PET and provide prognostic information beyond myocardial perfusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyag121","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:48:44Z","timestamp":1782992924000},"source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of left ventricular hypertrophy assessed with 15O-water positron emission tomography"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8382-3624","authenticated-orcid":false,"given":"Jonathan","family":"Sigfridsson","sequence":"first","affiliation":[{"name":"Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University , Uppsala ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Svanstr\u00f6m","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University , Uppsala ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2002-8699","authenticated-orcid":false,"given":"Tanja","family":"Kero","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University , Uppsala ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik J","family":"Harms","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University , Uppsala ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonny","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University , Uppsala ,","place":["Sweden"]},{"name":"Uppsala\/G\u00e4vleborg County, Centre for Research and Development , G\u00e4vle ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lubberink","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University , Uppsala ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3121-0938","authenticated-orcid":false,"given":"Jens","family":"S\u00f6rensen","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University , Uppsala 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