{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:24:23Z","timestamp":1791725063845,"version":"4.3.4"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL177076"],"award-info":[{"award-number":["R01 HL177076"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL 158077"],"award-info":[{"award-number":["R01 HL 158077"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["UM1TR004408"],"award-info":[{"award-number":["UM1TR004408"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007299","name":"Harvard Catalyst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007299","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Exercise cardiovascular magnetic resonance (Ex-CMR) assesses cardiac function under physiological stress. Imaging during continuous in-bore exercise reflects peak physiology but is challenging, prone to motion artefacts and patient discomfort. Exercise performed outside the scanner followed by rapid post-exercise imaging improves feasibility and image quality, but the time course of ventricular volume recovery after exercise cessation remains poorly defined. We compared biventricular Ex-CMR measurements during steady-state peak exercise with those acquired sequentially after exercise termination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Ten healthy adults [24 (21\u201331) years; 8 female] underwent Ex-CMR on a 3T system. Biventricular volumes were assessed using a free-breathing, electrocardiogram-triggered, highly accelerated multi-slice cine sequence with compressed sensing and deep learning-based reconstruction. Short-axis stacks were acquired at rest, during two steady-state peak exercise acquisitions, and at three sequential post-exercise timepoints, with the first recovery scan beginning 10\u201315\u2005s after cessation. Linear mixed-effects models evaluated recovery categorically and as a function of elapsed time. Differences between repeated peak acquisitions were small [left ventricular (LV) end-diastolic volume +1 \u00b1 3\u2005mL; LV end-systolic volume \u22124 \u00b1 7\u2005mL]. Immediately after cessation (13 \u00b1 2\u2005s), biventricular volumes remained unchanged vs. peak (all P = 1.00). Significant recovery-related changes emerged by 54 \u00b1 9\u2005s and were present for all parameters by 99 \u00b1 18\u2005s. Linear modelling showed LV stroke volume declining 2.1\u2005mL (\u22121.9%) per 10\u2005s, with similar right-ventricular trends. Post-exercise acquisitions showed higher diagnostic quality and fewer artefacts than in-bore imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Biventricular volumes measured immediately after exercise closely approximate peak physiology, whereas recovery changes occur rapidly and linearly thereafter. Rapid post-exercise acquisition offers a practical surrogate for peak measurements while improving image quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyag135","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:44:27Z","timestamp":1785843867000},"source":"Crossref","is-referenced-by-count":1,"title":["Peak exercise-to-recovery changes in biventricular volumes and function assessed by exercise cardiovascular magnetic resonance"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5589-8792","authenticated-orcid":false,"given":"Alexander","family":"Schulz","sequence":"first","affiliation":[{"name":"Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School , 330 Brookline Ave., Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2581-7015","authenticated-orcid":false,"given":"Nicole C Y","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School , 330 Brookline Ave., Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5627-2345","authenticated-orcid":false,"given":"Marcelline","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School , 330 Brookline Ave., Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8903-9352","authenticated-orcid":false,"given":"Long","family":"Ngo","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School , 330 Brookline Ave., Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1903-4042","authenticated-orcid":false,"given":"Kathryn","family":"Arcand","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School , 330 Brookline Ave., Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren J","family":"Manning","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School , 330 Brookline Ave., Boston, MA 02215 ,","place":["USA"]},{"name":"Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School , 330 Brookline Ave., Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1963-7138","authenticated-orcid":false,"given":"Reza","family":"Nezafat","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School , 330 Brookline Ave., Boston, MA 02215 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"2026081210071274100_qyag135-B1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1532-429X-15-35","article-title":"Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) board of trustees task force on standardized post processing","volume":"15","author":"Schulz-Menger","year":"2013","journal-title":"J Cardiovasc Magn Reson"},{"key":"2026081210071274100_qyag135-B2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jocmr.2025.101901","article-title":"Free-breathing single-beat exercise cardiovascular magnetic resonance with generative artificial intelligence for evaluation of volumetric and functional cardiac indices: a reproducibility study","volume":"27","author":"Ghanbari","year":"2025","journal-title":"J Cardiovasc Magn Reson"},{"key":"2026081210071274100_qyag135-B3","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s10554-024-03054-6","article-title":"Assessment of the cardiac output at rest and during exercise stress using real-time cardiovascular magnetic resonance imaging in HFpEF-patients","volume":"40","author":"Schulz","year":"2024","journal-title":"Int J Cardiovasc Imaging"},{"key":"2026081210071274100_qyag135-B4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12968-020-00652-w","article-title":"Exercise cardiovascular magnetic resonance: development, current utility and future applications","volume":"22","author":"Craven","year":"2020","journal-title":"J Cardiovasc Magn Reson"},{"key":"2026081210071274100_qyag135-B5","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1093\/ehjci\/jey050","article-title":"Exercise cardiac magnetic resonance to differentiate athlete's heart from structural heart disease","volume":"19","author":"Claessen","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026081210071274100_qyag135-B6","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.222878","article-title":"Accelerated cardiac MRI cine with use of resolution enhancement generative adversarial inline neural network","volume":"307","author":"Yoon","year":"2023","journal-title":"Radiology"},{"key":"2026081210071274100_qyag135-B7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12968-020-0598-4","article-title":"The application of exercise stress cardiovascular magnetic resonance in patients with suspected dilated cardiomyopathy","volume":"22","author":"Le","year":"2020","journal-title":"J Cardiovasc Magn Reson"},{"key":"2026081210071274100_qyag135-B8","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1161\/CIRCULATIONAHA.120.051542","article-title":"Exercise stress real-time cardiac magnetic resonance imaging for noninvasive characterization of heart failure with preserved ejection fraction","volume":"143","author":"Backhaus","year":"2021","journal-title":"Circulation"},{"key":"2026081210071274100_qyag135-B9","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.120.011823","article-title":"Impaired exercise tolerance in repaired tetralogy of fallot is associated with impaired biventricular contractile reserve: an exercise-stress real-time cardiovascular magnetic resonance study","volume":"14","author":"Steinmetz","year":"2021","journal-title":"Circ Cardiovasc Imaging"},{"key":"2026081210071274100_qyag135-B10","doi-asserted-by":"crossref","first-page":"R638","DOI":"10.1152\/ajpregu.00158.2018","article-title":"Exercise cardiac magnetic resonance imaging: a feasibility study and meta-analysis","volume":"315","author":"Beaudry","year":"2018","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2026081210071274100_qyag135-B11","doi-asserted-by":"crossref","DOI":"10.1148\/ryct.240175","article-title":"Establishing cardiac MRI reference ranges stratified by sex and age for cardiovascular function during exercise","volume":"7","author":"Schweitzer","year":"2025","journal-title":"Radiol Cardiothorac Imaging"}],"container-title":["European Heart Journal - Imaging Methods and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjimp\/advance-article-pdf\/doi\/10.1093\/ehjimp\/qyag135\/70493851\/qyag135.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjimp\/article-pdf\/4\/3\/qyag135\/70493851\/qyag135.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjimp\/article-pdf\/4\/3\/qyag135\/70493851\/qyag135.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:09:02Z","timestamp":1786543742000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjimp\/article\/doi\/10.1093\/ehjimp\/qyag135\/8752480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjimp\/qyag135","relation":{},"ISSN":["2755-9637"],"issn-type":[{"value":"2755-9637","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,7,2]]},"article-number":"qyag135"}}