{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:52:37Z","timestamp":1791474757515,"version":"4.3.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":76,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Patients with single ventricle (SV) congenital heart disease typically undergo surgical palliation that reroutes the superior\/inferior vena cava (SVC\/IVC) directly to the pulmonary arteries, which alters vascular flow dynamics. Four-dimensional flow (4DF) cardiovascular magnetic resonance (CMR), particularly with ferumoxytol contrast, enables comprehensive assessment of flow distribution and wall shear stress (WSS) in small paediatric vessels. This study aimed to evaluate the differences in caval flow and WSS between SV and BiV patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We retrospectively analysed patients who underwent clinically indicated ferumoxytol-enhanced (FE) 4DF CMR between 2019 and 2024. Patients with anomalous systemic or pulmonary venous return were excluded. 4DF data were evaluated on the cloud-based Tempus platform. Flow in the SVC, IVC, aorta, and descending aorta was quantified and indexed to the body surface area. The average WSS over time was measured. Among 387 patients (n = 126 for SV; n = 261 for BiV), SV patients had lower indexed SVC flow (1.11 \u00b1 0.51 vs. 1.50 \u00b1 0.69\u2005L\/min\/m2, P &amp;lt; 0.0001) and lower WSS (16.0 \u00b1 6.4 vs. 22.7 \u00b1 9.1 cPa, P &amp;lt; 0.0001) compared with BiV patients. The SVC\/caval flow ratio declined with age and body surface area, remaining independently lower in the SV group after multivariable adjustment (P = 0.0005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SV physiology is associated with lower SVC flow and WSS independent of age or body size, suggesting altered systemic venous return intrinsic to cavopulmonary circulation. 4DF CMR is a valuable tool for assessing and monitoring systemic venous physiology in congenital heart disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjimp\/qyag158","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:18:03Z","timestamp":1789384683000},"source":"Crossref","is-referenced-by-count":0,"title":["Altered caval flow and wall shear stress in single ventricle circulation: insights from ferumoxytol-enhanced 4D flow MRI"],"prefix":"10.1093","volume":"4","author":[{"given":"Vasupradha","family":"Suresh Kumar","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Heart Research Institute, Children's National Hospital , Washington DC 20010 ,","place":["USA"]},{"name":"Division of Pediatric Cardiology, Hasbro Children\u2019s Hospital\/Brown University , Providence, RI 02903 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Kollar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Heart Research Institute, Children's National Hospital , Washington DC 20010 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi V","family":"Vegulla","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Heart Research Institute, Children's National Hospital , Washington DC 20010 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areen","family":"Almarkhan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Heart Research Institute, Children's National Hospital , Washington DC 20010 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-1342","authenticated-orcid":false,"given":"Andrew","family":"Waberski","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Heart Research Institute, Children's National Hospital , Washington DC 20010 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1003-1903","authenticated-orcid":false,"given":"Yue-Hin","family":"Loke","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Heart Research Institute, Children's National Hospital , Washington DC 20010 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"2026100811070804200_qyag158-B1","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2024.109317","article-title":"Biomechanics and clinical implications of Fontan upsizing","volume":"183","author":"Govindarajan","year":"2024","journal-title":"Comput Biol Med"},{"key":"2026100811070804200_qyag158-B2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.athoracsur.2007.08.062","article-title":"Caval blood flow during supine exercise in normal and Fontan patients","volume":"85","author":"Hjortdal","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"2026100811070804200_qyag158-B3","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.123.016104","article-title":"Impact of age-related change in caval flow ratio on hepatic flow distribution in the Fontan circulation","volume":"17","author":"Govindarajan","year":"2024","journal-title":"Circ Cardiovasc Imaging"},{"key":"2026100811070804200_qyag158-B4","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jtcvs.2008.11.062","article-title":"Blood flow distribution in a large series of patients having the Fontan operation: a cardiac magnetic resonance velocity mapping study","volume":"138","author":"Whitehead","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026100811070804200_qyag158-B5","doi-asserted-by":"crossref","DOI":"10.1016\/j.siny.2020.101122","article-title":"Superior vena cava flow: role, assessment and controversies in the management of perinatal perfusion","volume":"25","author":"De Waal","year":"2020","journal-title":"Semin Fetal Neonatal Med"},{"key":"2026100811070804200_qyag158-B6","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1161\/01.CIR.92.7.1860","article-title":"Contribution of superior vena caval flow to total cardiac output in children. 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