{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:51:51Z","timestamp":1791467511085,"version":"4.3.4"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":76,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This retrospective cohort study evaluated the relationship between serum \u03b2-hydroxybutyrate (BHB) levels and myocardial glucose suppression in 74 patients undergoing fluorine-18 fluorodeoxyglucose positron emission tomography for suspected cardiac sarcoidosis. The average BHB concentration prior to FDG administration was 0.94 \u00b1 0.78\u2005mmol\/L. The septal-to-blood pool uptake ratio (SUVmax_septal\/SUVmean_blood pool) ranged from 0.50 to 0.88, with a median of 0.66 (Quartile 1 = 0.58; Quartile 3 = 0.73). No significant association was found between BHB levels and the septal-to-blood pool uptake ratio (r = 0.09; P = 0.48), suggesting a metabolic plateau regarding myocardial glucose utilization once adequate ketosis is achieved. These preliminary findings support a threshold effect rather than a dose-dependent relationship between serum BHB levels and myocardial glucose suppression following appropriate dietary preparation.<\/jats:p>","DOI":"10.1093\/ehjimp\/qyag161","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:30:35Z","timestamp":1789558235000},"source":"Crossref","is-referenced-by-count":0,"title":["Magnitude of serum \u03b2-hydroxybutyrate elevations and myocardial glucose suppression in fluorine-18 fluorodeoxyglucose positron emission tomography for cardiac sarcoidosis"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4228-7347","authenticated-orcid":false,"given":"Lamis","family":"El Harake","sequence":"first","affiliation":[{"name":"Division of Cardiology, Bluhm Cardiovascular Institute , Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8563-1554","authenticated-orcid":false,"given":"Richard","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Bluhm Cardiovascular Institute , Chicago, IL ,","place":["USA"]},{"name":"Bluhm Cardiovascular Institute, Feinberg School of Medicine, Northwestern University , 676 N St Clair St: Suite 700, Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ike","family":"Okwuosa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Bluhm Cardiovascular Institute , Chicago, IL ,","place":["USA"]},{"name":"Bluhm Cardiovascular Institute, Feinberg School of Medicine, Northwestern University , 676 N St Clair St: Suite 700, Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7913-0574","authenticated-orcid":false,"given":"Ryan","family":"Avery","sequence":"additional","affiliation":[{"name":"Bluhm Cardiovascular Institute, Feinberg School of Medicine, Northwestern University , 676 N St Clair St: Suite 700, Chicago, IL ,","place":["USA"]},{"name":"Department of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Lehrer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Bluhm Cardiovascular Institute , Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C","family":"Cremer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Bluhm Cardiovascular Institute , Chicago, IL ,","place":["USA"]},{"name":"Bluhm Cardiovascular Institute, Feinberg School of Medicine, Northwestern University , 676 N St Clair St: Suite 700, Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"2026100808570109500_qyag161-B1","first-page":"1172","article-title":"Relationship of F-18 fluorodeoxyglucose uptake in myocardium and blood pool to biomarkers","volume":"58","author":"Larson","year":"2017","journal-title":"J Nucl Med"},{"key":"2026100808570109500_qyag161-B2","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/s12350-023-03209-3","article-title":"Utility of serum ketone levels for assessment of myocardial glucose suppression for 18F-fluorodeoxyglucose PET in patients referred for evaluation of endocarditis","volume":"30","author":"Madamanchi","year":"2023","journal-title":"J Nucl Cardiol"},{"key":"2026100808570109500_qyag161-B3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s12350-016-0502-7","article-title":"Patient preparation for cardiac fluorine-18 fluorodeoxyglucose positron emission tomography imaging of inflammation","volume":"24","author":"Osborne","year":"2016","journal-title":"J Nucl Cardiol"},{"key":"2026100808570109500_qyag161-B4","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00259-022-06062-7","article-title":"The utility of beta-hydroxybutyrate in detecting myocardial glucose uptake suppression in patients undergoing inflammatory [18F]-FDG PET studies","volume":"50","author":"Alfawara","year":"2023","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2026100808570109500_qyag161-B5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/cpf.12881","article-title":"Point-of-care \u03b2-hydroxybutyrate measurement predicts adequate glucose metabolism suppression in cardiac FDG-PET\/CT","volume":"44","author":"Hartikainen","year":"2024","journal-title":"Clin Physiol Funct Imaging"}],"container-title":["European Heart Journal - Imaging Methods and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjimp\/advance-article-pdf\/doi\/10.1093\/ehjimp\/qyag161\/71122066\/qyag161.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjimp\/article-pdf\/4\/3\/qyag161\/71122066\/qyag161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjimp\/article-pdf\/4\/3\/qyag161\/71122066\/qyag161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:57:11Z","timestamp":1791464231000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjimp\/article\/doi\/10.1093\/ehjimp\/qyag161\/8801969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjimp\/qyag161","relation":{},"ISSN":["2755-9637"],"issn-type":[{"value":"2755-9637","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,7,2]]},"article-number":"qyag161"}}