{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:08:19Z","timestamp":1781863699348,"version":"3.54.5"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Karolinska Institutet, the Swedish Heart-Lung Foundation, and the Stockholm County Council"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Low testosterone has been associated with cardiovascular disease in men but with contradictory findings. Testosterone bind to the androgen receptor and polymorphisms of the receptor gene such as CAG repeat length may affect transcriptional activity, possibly mitigating testosterone effects. The aims were to study the CAG repeat length and testosterone levels at four time points following a myocardial infarction (MI) and to analyse possible relationships between CAG repeat length and cardiovascular prognosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Male patients admitted for acute MI (n = 122) from the Glucose in Acute Myocardial Infarction study were included. Blood samples were drawn at four time points (day after admission, at discharge, and at 3 and 12 months post-infarction) for assessment of testosterone levels. Patients were followed for a median of 11.6 years. Cox regression analyses were performed for CAG repeat length by one unit increment and by &amp;gt; vs. \u2264median for cardiovascular events and all-cause mortality. Median CAG repeat length was 20. There was no difference in testosterone levels at each time point when dividing the cohort into \u2264 vs. &amp;gt;CAG repeat median (=20). There was no association between CAG repeat length either as a continuous or categorical variable in unadjusted and age-adjusted Cox analyses for cardiovascular events. While CAG &amp;gt;20 was associated with all-cause mortality in unadjusted analyses (hazard ratio 2.19, 95% confidence interval 1.13\u20134.22; P = 0.02), it did not remain significant following adjustment for age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>CAG repeat length was not associated with testosterone levels or prognosis in men with acute MI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeab023","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T14:01:12Z","timestamp":1629900072000},"source":"Crossref","is-referenced-by-count":2,"title":["Androgen receptor polymorphism, testosterone levels, and prognosis in patients with acute myocardial infarction"],"prefix":"10.1093","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4047-7730","authenticated-orcid":false,"given":"Anne","family":"Wang","sequence":"first","affiliation":[{"name":"Cardiology Unit, Department of Medicine, Solna, Karolinska Institutet , Stockholm 171 76, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Center for Andrology and Sexual Medicine (ANOVA), Department of Medicine, Huddinge, Karolinska Institutet , Stockholm 141 86, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Arver","sequence":"additional","affiliation":[{"name":"Center for Andrology and Sexual Medicine (ANOVA), Department of Medicine, Huddinge, Karolinska Institutet , Stockholm 141 86, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Norhammar","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medicine, Solna, Karolinska Institutet , Stockholm 171 76, Sweden"},{"name":"Capio S:t G\u00f6rans Hospital , Stockholm 113 19, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"N\u00e4sman","sequence":"additional","affiliation":[{"name":"Center for Safety Research, KTH Royal Institute of Technology , SE-100 44, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Ryd\u00e9n","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medicine, Solna, Karolinska Institutet , Stockholm 171 76, Sweden"},{"name":"Heart and Vascular Theme, Karolinska University Hospital , Stockholm 171 76, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda G","family":"Mellbin","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medicine, Solna, Karolinska Institutet , Stockholm 171 76, Sweden"},{"name":"Heart and Vascular Theme, Karolinska University Hospital , Stockholm 171 76, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"2024011619414435100_oeab023-B1","doi-asserted-by":"crossref","first-page":"e000272","DOI":"10.1161\/JAHA.113.000272","article-title":"Testosterone and the cardiovascular system: a comprehensive review of the clinical literature","volume":"2","author":"Oskui","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"2024011619414435100_oeab023-B2","doi-asserted-by":"crossref","first-page":"298107","DOI":"10.1155\/2015\/298107","article-title":"Influence of CAG repeat polymorphism on the targets of testosterone action","volume":"2015","author":"Tirabassi","year":"2015","journal-title":"Int J Endocrinol"},{"key":"2024011619414435100_oeab023-B3","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/S0140-6736(02)09089-X","article-title":"Glucose metabolism in patients with acute myocardial 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Endocrinol"},{"key":"2024011619414435100_oeab023-B6","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1365-2605.2008.00942.x","article-title":"Androgen receptor gene polymorphism and the metabolic syndrome in 60-80 years old Norwegian men","volume":"33","author":"Skjaerpe","year":"2008","journal-title":"Int J Androl"},{"key":"2024011619414435100_oeab023-B7","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1177\/1479164118802543","article-title":"Dynamics of testosterone levels in patients with newly detected glucose abnormalities and acute myocardial infarction","volume":"15","author":"Wang","year":"2018","journal-title":"Diab Vasc Dis Res"},{"key":"2024011619414435100_oeab023-B8","doi-asserted-by":"crossref","first-page":"e3081","DOI":"10.1002\/dmrr.3081","article-title":"Interactive effects of testosterone and the androgen receptor CAG repeat length polymorphism on cardiovascular-renal events and mortality in men with diabetes","volume":"35","author":"Wong","year":"2019","journal-title":"Diabetes Metab Res Rev"},{"key":"2024011619414435100_oeab023-B9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/XCE.0000000000000230","article-title":"Androgen receptor-reduced sensitivity is associated with increased mortality and poorer glycaemia in men with type 2 diabetes mellitus: a prospective cohort study","volume":"10","author":"Heald","year":"2020","journal-title":"Cardiovasc Endocrinol Metab"}],"container-title":["European Heart Journal 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