{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T19:45:52Z","timestamp":1771357552381,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Western Regional Health Authorities and Department of Medicine, Haugesund Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Patients with severe obesity are predisposed to left ventricular (LV) hypertrophy, increased myocardial oxygen demand, and impaired myocardial mechanics. Bariatric surgery leads to rapid weight loss and improves cardiovascular risk profile. The present prospective study assesses whether LV wall mechanics improve 1 year after bariatric surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Ninety-four severely obese patients [43 \u00b1 10 years, 71% women, body mass index (BMI) 41.8 \u00b1 4.9 kg\/m2, 57% with hypertension] underwent echocardiography before, 6 months and 1 year after gastric bypass surgery in the FatWest (Bariatric Surgery on the West Coast of Norway) study. We assessed LV mechanics by midwall shortening (MWS) and global longitudinal strain (GLS), LV power\/mass as 0.222 \u00d7 cardiac output \u00d7 mean blood pressure (BP)\/LV mass, and myocardial oxygen demand as the LV mass-wall stress-heart rate product. Surgery induced a significant reduction in BMI, heart rate, and BP (P &amp;lt; 0.001). Prevalence of LV hypertrophy fell from 35% to 19% 1 year after surgery (P &amp;lt; 0.001). The absolute value of GLS improved by\u20144.6% (i.e. 29% increase in GLS) while LV ejection fraction, MWS, and LV power\/mass remained unchanged. In multivariate regression analyses, 1 year improvement in GLS was predicted by lower preoperative GLS, larger mean BP, and BMI reduction (all P &amp;lt; 0.05). Low 1-year MWS was associated with female sex, preoperative hypertension, and higher 1-year LV relative wall thickness and myocardial oxygen demand (all P &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In severely obese patients, LV longitudinal function is largely recovered one year after bariatric surgery due to reduced afterload. LV midwall mechanics does not improve, particularly in women and patients with persistent LV geometric abnormalities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>ClinicalTrials.gov identifier<\/jats:title>\n                  <jats:p>NCT01533142, 15 February 2012.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeab024","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T15:15:03Z","timestamp":1629472503000},"source":"Crossref","is-referenced-by-count":22,"title":["One-year impact of bariatric surgery on left ventricular mechanics: results from the prospective FatWest study"],"prefix":"10.1093","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9310-6394","authenticated-orcid":false,"given":"Lisa M D","family":"Grymyr","sequence":"first","affiliation":[{"name":"Haukeland University Hospital, Jonas Liesvei 65, 5021 Bergen 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