{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:52:08Z","timestamp":1790884328898,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Japanese Association of Cardiovascular Intervention and Therapeutics"},{"name":"Japanese Agency for Medical Research and Developments","award":["17ek0110097h0001"],"award-info":[{"award-number":["17ek0110097h0001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We examined in-hospital outcomes of patients that required mechanical circulatory support (MCS), such as intra-aortic balloon pumping (IABP), Impella\u00ae, or veno-arterial extracorporeal membrane oxygenation (VA-ECMO), for elective percutaneous coronary interventions (PCIs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The J-PCI is a prospective Japanese nationwide multicentre registry sponsored by the Japanese Association of Cardiovascular Intervention and Therapeutics (CVIT) and designed to collect clinical variables and in-hospital outcome data on consecutive patients undergoing PCI. Of the 253\u2009228 patients registered between January 2018 and December 2018, 1627 patients (0.6%) undergoing elective PCI under MCS at 551 sites were analyzed. The mean age of the patients was 74 years, and 25.2% of the patients were females. Multivessel disease and left main disease were observed in 59.0% and 19.7% of the patients, respectively. Majority of patients were treated with IABP alone (86.2%), followed by IABP plus VA-ECMO (6.0%) and Impella alone (3.9%). In-hospital mortality was reported in 134 patients (8.2%). Cardiac death was more common than non-cardiac death (6.8% vs. 1.5%). About 34.6% of the patients receiving VA-ECMO died during hospitalization, whereas 7.2% and 5.3% of patients receiving Impella and IABP died, respectively (P\u2009&amp;lt;\u20090.01). The proportion of patients with VA-ECMO or Impella who had major bleeding requiring blood transfusion was higher than that of patients with IABP (14.1% vs. 13.0% vs. 2.8%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In the setting of elective PCI, in-hospital mortality of patients requiring MCS was considerably high. VA-ECMO or Impella was associated with a higher risk of major bleeding than IABP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeac041","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T14:01:42Z","timestamp":1656338502000},"source":"Crossref","is-referenced-by-count":17,"title":["Mechanical circulatory support devices for elective percutaneous coronary interventions: novel insights from the Japanese nationwide J-PCI registry"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5925-2489","authenticated-orcid":false,"given":"Takashi","family":"Muramatsu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Fujita Health University Hospital , Toyoake , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Inohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3779-2972","authenticated-orcid":false,"given":"Shun","family":"Kohsaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-9186","authenticated-orcid":false,"given":"Kyohei","family":"Yamaji","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyoto University , Kyoto , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine , Maebashi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Shinke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Showa University School of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuo","family":"Toriya","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Fujita Health University Hospital , Toyoake , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yoshiki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fujita Health University Okazaki Medical Center , Okazaki , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fujita Health University Okazaki Medical Center , Okazaki , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aichi Medical University , Nagakute , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aichi Medical University , Nagakute , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-3469","authenticated-orcid":false,"given":"Masato","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Toho University Ohashi Medical Center , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5686-4324","authenticated-orcid":false,"given":"Yuji","family":"Ikari","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokai University School of Medicine , Isehara , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"2022072507091053800_oeac041-B1","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.jcin.2016.02.046","article-title":"A practical approach to mechanical circulatory support in patients undergoing percutaneous coronary intervention: an interventional perspective","volume":"9","author":"Atkinson","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"key":"2022072507091053800_oeac041-B2","doi-asserted-by":"publisher","first-page":"E262","DOI":"10.1002\/ccd.27375","article-title":"Temporal trends in percutaneous coronary interventions thru the drug eluting stent era: insights from 18,641 procedures performed over 12-year period","volume":"92","author":"Landes","year":"2018","journal-title":"Catheter Cardiovasc Interv"},{"key":"2022072507091053800_oeac041-B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2020.12.019","article-title":"Temporal trends in patient risk profile and clinical outcomes following percutaneous coronary intervention","author":"Dawson","year":"2020","journal-title":"Cardiovasc Revasc Med"},{"key":"2022072507091053800_oeac041-B4","first-page":"81","article-title":"Mechanical circulatory support in chronic total occlusion percutaneous coronary intervention: insights from a multicenter U.S. Registry","volume":"30","author":"Danek","year":"2018","journal-title":"J Invasive Cardiol"},{"key":"2022072507091053800_oeac041-B5","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s12928-020-00669-z","article-title":"Contemporary use and trends in percutaneous coronary intervention in Japan: an outline of the J-PCI registry","volume":"35","author":"Sawano","year":"2020","journal-title":"Cardiovasc Interv Ther"},{"key":"2022072507091053800_oeac041-B6","doi-asserted-by":"publisher","DOI":"10.1007\/s12928-021-00832-0","article-title":"Japanese Nationwide PCI (J-PCI) Registry Annual Report 2019: patient demographics and in-hospital outcomes","author":"Ando","year":"2022","journal-title":"Cardiovasc Interv Ther"},{"key":"2022072507091053800_oeac041-B7","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.106.685313","article-title":"Clinical end points in coronary stent trials: a case for standardized definitions","volume":"115","author":"Cutlip","year":"2007","journal-title":"Circulation"},{"key":"2022072507091053800_oeac041-B8","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1056\/NEJMoa1208410","article-title":"Intraaortic balloon support for myocardial infarction with cardiogenic shock","volume":"367","author":"Thiele","year":"2012","journal-title":"N Engl J Med"},{"key":"2022072507091053800_oeac041-B9","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/j.jacc.2020.07.037","article-title":"Comparative Trends in Percutaneous Coronary Intervention in Japan and the United States, 2013 to 2017","volume":"76","author":"Inohara","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2022072507091053800_oeac041-B10","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1067\/mhj.2003.14","article-title":"Elective versus provisional intra-aortic balloon pumping in high-risk percutaneous transluminal coronary angioplasty","volume":"145","author":"Briguori","year":"2003","journal-title":"Am Heart J"},{"key":"2022072507091053800_oeac041-B11","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1161\/CIRCULATIONAHA.112.098194","article-title":"A prospective, randomized clinical trial of hemodynamic support with Impella 2.5 versus intra-aortic balloon pump in patients undergoing high-risk percutaneous coronary intervention: the PROTECT II study","volume":"126","author":"O\u2019Neill","year":"2012","journal-title":"Circulation"},{"key":"2022072507091053800_oeac041-B12","doi-asserted-by":"publisher","first-page":"E501-E512","DOI":"10.1002\/ccd.29758","article-title":"Outcomes of bailout percutaneous ventricular assist device versus prophylactic strategy in patients undergoing nonemergent percutaneous coronary intervention","volume":"98","author":"O\u2019Neill","year":"2021","journal-title":"Catheter Cardiovasc Interv"},{"key":"2022072507091053800_oeac041-B13","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1177\/2048872618822460","article-title":"Incidence and outcome of peri-procedural cardiogenic shock: results from the international Euro Heart Survey PCI registry","volume":"9","author":"Weipert","year":"2020","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"2022072507091053800_oeac041-B14","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jcin.2008.11.006","article-title":"Survival of elderly patients undergoing percutaneous coronary intervention for acute myocardial infarction complicated by cardiogenic shock","volume":"2","author":"Lim","year":"2009","journal-title":"JACC Cardiovasc Interv"},{"key":"2022072507091053800_oeac041-B15","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1001\/jama.2013.1556","article-title":"Association between bleeding events and in-hospital mortality after percutaneous coronary intervention","volume":"309","author":"Chhatriwalla","year":"2013","journal-title":"JAMA"},{"key":"2022072507091053800_oeac041-B16","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1016\/j.jacc.2015.01.047","article-title":"Association of spontaneous bleeding and myocardial infarction with long-term mortality after percutaneous coronary intervention","volume":"65","author":"Kazi","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2022072507091053800_oeac041-B17","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1253\/circj.CJ-20-0836","article-title":"Application of the Modified High Bleeding Risk Criteria for Japanese Patients in an All-Comers Registry of Percutaneous Coronary Intervention- From the CREDO-Kyoto Registry Cohort-3","volume":"85","author":"Natsuaki","year":"2021","journal-title":"Circ J"},{"key":"2022072507091053800_oeac041-B18","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1253\/circj.CJ-19-0440","article-title":"Surgical ineligibility and long-term outcomes in patients with severe coronary artery disease","volume":"83","author":"Matsumura-Nakano","year":"2019","journal-title":"Circ J"},{"key":"2022072507091053800_oeac041-B19","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1161\/CIRCULATIONAHA.114.011541","article-title":"Surgical ineligibility and mortality among patients with unprotected left main or multivessel coronary artery disease undergoing percutaneous coronary intervention","volume":"130","author":"Waldo","year":"2014","journal-title":"Circulation"},{"key":"2022072507091053800_oeac041-B20","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1056\/NEJM199908263410901","article-title":"Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock","volume":"341","author":"Hochman","year":"1999","journal-title":"N Engl J Med"},{"key":"2022072507091053800_oeac041-B21","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.ahj.2013.12.018","article-title":"Evaluating the learning curve in the prospective Randomized Clinical Trial of hemodynamic support with Impella 2.5 versus Intra-Aortic Balloon Pump in patients undergoing high-risk percutaneous coronary intervention: a prespecified subanalysis of the PROTECT II study","volume":"167","author":"Henriques","year":"2014","journal-title":"Am Heart J"}],"container-title":["European Heart Journal Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjopen\/advance-article-pdf\/doi\/10.1093\/ehjopen\/oeac041\/44265378\/oeac041.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjopen\/article-pdf\/2\/4\/oeac041\/45054730\/oeac041.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjopen\/article-pdf\/2\/4\/oeac041\/45054730\/oeac041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T07:09:25Z","timestamp":1658732965000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjopen\/article\/doi\/10.1093\/ehjopen\/oeac041\/6618596"}},"subtitle":[],"editor":[{"given":"Salvatore","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,27]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7,7]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjopen\/oeac041","relation":{},"ISSN":["2752-4191"],"issn-type":[{"value":"2752-4191","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,6,27]]},"article-number":"oeac041"}}