{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:07:11Z","timestamp":1791446831157,"version":"4.3.3"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Takotsubo syndrome (TTS) is an acute and reversible left ventricular dysfunction and can be complicated by cardiogenic shock (CS). However, few data are available on optimal care in TTS complicated by CS. Aim of this study was to evaluate short- and long-term impact of intra-aortic balloon pumping (IABP) on mortality in this setting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In a multi-centre, international registry on TTS, 2248 consecutive patients were enrolled from 38 centres from Germany, Italy, and Spain. Of the 2248 patients, 212 (9.4%) experienced CS. Patients with CS had a higher prevalence of diabetes (27% vs. 19%), male sex (25% vs. 10%), and right ventricular involvement (10% vs. 5%) (P &amp;lt; 0.01 in all cases). Forty-three patients with CS (20% of 212) received IABP within 8\u2005h (interquartile range 4\u201318) after admission. No differences in terms of age, gender, cardiovascular risk factors, and admission left ventricular ejection fraction were found among patients with and without IABP. There were no significant differences in terms of 30-day mortality (16% vs. 17%, P = 0.98), length of hospitalization (18.9 vs. 16.7 days, P = 0.51), and need of invasive ventilation (35% vs. 41%, P = 0.60) among two groups: 30-day survival was not significantly different even after propensity score adjustment (log-rank P = 0.73). At 42-month follow-up, overall mortality in patients with CS and TTS was 35%, not significantly different between patients receiving IABP and not (37% vs. 35%, P = 0.72).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In a large multi-centre observational registry, the use of IABP was not associated with lower mortality rates at short- and long-term follow-up in patients with TTS and CS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oead003","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T14:27:55Z","timestamp":1674570475000},"source":"Crossref","is-referenced-by-count":24,"title":["Impact of intra-aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syndrome complicated by cardiogenic shock: results from the German-Italian-Spanish (GEIST) registry"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-6513","authenticated-orcid":false,"given":"Francesco","family":"Santoro","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia , Viale Pinto n.1, 71122 Foggia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n J","family":"N\u00fa\u00f1ez Gil","sequence":"additional","affiliation":[{"name":"Interventional, Cardiology, Cardiovascular Institute. Hospital Cl\u00ednico Universitario San Carlos , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stiermaier","sequence":"additional","affiliation":[{"name":"University Heart Center L\u00fcbeck, Medical Clinic II (Cardiology\/Angiology\/Intensive Care Medicine) and German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck , L\u00fcbeck , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"El-Battrawy","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM) University of Heidelberg , Mannheim , Germany"},{"name":"German Center for Cardiovascular Research, Partner Site, Heidelberg-Mannheim , Mannheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Moeller","sequence":"additional","affiliation":[{"name":"University Heart Center L\u00fcbeck, Medical Clinic II (Cardiology\/Angiology\/Intensive Care Medicine) and German Center for Cardiovascular Research (DZHK), partner site Hamburg\/Kiel\/L\u00fcbeck , L\u00fcbeck , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5394-1312","authenticated-orcid":false,"given":"Federico","family":"Guerra","sequence":"additional","affiliation":[{"name":"Cardiology and Arrhythmology Clinic, Marche Polytechnic University, University Hospital \u2018Umberto I\u2014Lancisi\u2014Salesi\u2019 , Ancona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Novo","sequence":"additional","affiliation":[{"name":"Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Cardiology Unit , Palermo , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1410-6845","authenticated-orcid":false,"given":"Luca","family":"Arcari","sequence":"additional","affiliation":[{"name":"Cardiology, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology, Sapienza University of Rome , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Musumeci","sequence":"additional","affiliation":[{"name":"Cardiology, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology, Sapienza University of Rome , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cacciotti","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Madre Giuseppina Vannini Hospital , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Mariano","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Rome Tor Vergata , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Romeo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Rome Tor Vergata , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Cannone","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bonomo Hospital , Andria , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Caldarola","sequence":"additional","affiliation":[{"name":"Cardiology Department, San Paolo Hospital , Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Giannini","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research, Partner Site, Heidelberg-Mannheim , Mannheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Mallardi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia , Viale Pinto n.1, 71122 Foggia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Leopizzi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia , Viale Pinto n.1, 71122 Foggia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Vitale","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia , Viale Pinto n.1, 71122 Foggia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Montisci","sequence":"additional","affiliation":[{"name":"San Giovanni di Dio Hospital, University of Cagliari , Cagliari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Meloni","sequence":"additional","affiliation":[{"name":"San Giovanni di Dio Hospital, University of Cagliari , Cagliari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Department of cardiac Anesthesia and Intensive care unit, Santa Maria Hospital, GVM Care and Research , Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Di Biase","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia , Viale Pinto n.1, 71122 Foggia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Almendro-Delia","sequence":"additional","affiliation":[{"name":"Servicio de Cardiolog\u00eda, Hospital Virgen de la Macarena , Sevilla , 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