{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:50:50Z","timestamp":1787615450455,"version":"build-2736575974"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We wanted to assess if 15O-H2O myocardial perfusion imaging (MPI) in a clinical setting can predict referral to coronary artery catheterization [coronary angiography (CAG)], execution of percutaneous coronary intervention (PCI), and post-PCI angina relief for patients with angina and previous coronary artery bypass graft (CABG).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We analysed 172 symptomatic CABG patients referred for 15O-H2O positron emission tomography (PET) MPI at Aarhus University Hospital Department of Nuclear Medicine &amp; PET Centre, of which five did not complete the scan. In total, 145 (87%) enrolled patients had an abnormal MPI. Of these, 86\/145 (59%) underwent CAG within 3 months; however, no PET parameters predicted referral to CAG. During the CAG, 25\/86 (29%) patients were revascularized by PCI. Relative flow reserve (RFR) (0.49 vs. 0.54 P = 0.03), vessel-specific myocardial blood flow (MBF) (1.53 vs. 1.88\u2005mL\/g\/min, P &amp;lt; 0.01), and vessel-specific myocardial flow reserve (MFR) (1.73 vs. 2.13, P &amp;lt; 0.01) were significantly lower in patients revascularized by PCI. Receiver operating characteristic analysis of the vessel-specific parameters yielded optimal cutoffs of 1.36\u2005mL\/g\/min (MBF) and 1.28 (MFR) to predict PCI. Angina relief was experienced by 18\/24 (75%) of the patients who underwent PCI. Myocardial blood flow was an excellent predictor of angina relief on both a global [area under the curve (AUC) = 0.85, P &amp;lt; 0.01] and vessel-specific (AUC = 0.90, P &amp;lt; 0.01) level with optimal cutoff levels of 1.99\u2005mL\/g\/min and 1.85\u2005mL\/g\/min, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>For CABG patients, RFR, vessel-specific MBF, and vessel-specific MFR measured by 15O-H2O PET MPI predict whether subsequent CAG will result in PCI. Additionally, global and vessel-specific MBF values predict post-PCI angina relief.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oead044","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T15:38:34Z","timestamp":1682696314000},"source":"Crossref","is-referenced-by-count":12,"title":["Myocardial perfusion imaging by 15O-H2O positron emission tomography predicts clinical revascularization procedures in symptomatic patients with previous coronary artery bypass graft"],"prefix":"10.1093","volume":"3","author":[{"given":"Mazen","family":"Vester","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine & PET Centre, Aarhus University Hospital , Palle Juul-Jensens Boulevard 165, 8200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-5329","authenticated-orcid":false,"given":"Simon","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine & PET Centre, Aarhus University Hospital , Palle Juul-Jensens Boulevard 165, 8200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Louise Gram","family":"Kj\u00e6rulff","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine & PET Centre, Aarhus University Hospital , Palle Juul-Jensens Boulevard 165, 8200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Poulsen","family":"Tolbod","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine & PET Centre, Aarhus University Hospital , Palle Juul-Jensens Boulevard 165, 8200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bent Roni Rangh\u00f8j","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen Dalby","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Aarhus , Denmark"},{"name":"Department of Clinical Medicine, Aarhus University , Palle Juul-Jensens Boulevard 11, building A, 10th floor, 8200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evald H\u00f8j","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Aarhus , Denmark"},{"name":"Department of Clinical Medicine, Aarhus University , Palle Juul-Jensens Boulevard 11, building A, 10th floor, 8200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Hostrup","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-9983","authenticated-orcid":false,"given":"Jens","family":"S\u00f6rensen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine & PET Centre, Aarhus University Hospital , Palle Juul-Jensens Boulevard 165, 8200 Aarhus N , Denmark"},{"name":"Department of Surgical Sciences, Nuclear Medicine and PET, Uppsala University , Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-1305","authenticated-orcid":false,"given":"Lars Christian","family":"Gormsen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine & PET Centre, Aarhus University Hospital , Palle Juul-Jensens Boulevard 165, 8200 Aarhus N , Denmark"},{"name":"Department of Clinical Medicine, Aarhus University , Palle Juul-Jensens Boulevard 11, building A, 10th floor, 8200 Aarhus N , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"2023070611321620200_oead044-B1","first-page":"e9349","article-title":"Global epidemiology of ischemic heart disease: results from the global burden of disease study","volume":"12","author":"Khan","year":"2020","journal-title":"Cureus"},{"key":"2023070611321620200_oead044-B2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.7326\/0003-4819-157-10-201211200-00010","article-title":"Diagnosis of stable ischemic heart disease: summary of a clinical practice guideline from the American College of Physicians\/American College of Cardiology Foundation\/American Heart Association\/American Association for Thoracic Surgery\/Preventive Cardiovascular Nurses Association\/Society of Thoracic 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