{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:02:25Z","timestamp":1793091745287,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["20H03927"],"award-info":[{"award-number":["20H03927"]}]},{"name":"JSPS KAKENHI","award":["21H03179"],"award-info":[{"award-number":["21H03179"]}]},{"name":"JSPS KAKENHI","award":["22H03330"],"award-info":[{"award-number":["22H03330"]}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labor, and Welfare of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005072","name":"Japanese Circulation Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20314864"],"award-info":[{"award-number":["20314864"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["22672854"],"award-info":[{"award-number":["22672854"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We aimed to determine if coronary artery calcium (CAC) is associated with cardiovascular disease (CVD) events, defined as CVD-related death, unstable angina, myocardial infarction, or staged revascularization among patients with heterozygous familial hypercholesterolaemia (HeFH) under primary prevention settings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Data of patients with FH admitted to Kanazawa University Hospital between 2000 and 2020, who underwent CAC measurement and were followed up (n = 622, male = 306, mean age = 54 years), were retrospectively reviewed. Risk factors for CVD events were determined using the Cox proportional hazard model. The median follow-up duration was 13.2 years (interquartile range: 9.8\u201318.4 years). We observed 132 CVD events during the follow-up period. The event rate per 1000 person-years for CAC scores of 0 [n = 283 (45.5%)], 1\u2013100 [n = 260 (41.8%)], and &amp;gt;100 [n = 79 (12.7%)] was 1.2, 17.0, and 78.8, respectively. Log (CAC score + 1) was a significant predictor of the occurrence of CVD events (hazard ratio: 3.24; 95% confidence interval: 1.68\u20134.80; P &amp;lt; 0.0001) in the multivariate Cox regression analysis, independent of other factors. The risk discrimination of CVD events was enhanced by adding CAC information to other conventional risk factors (C-statistics: 0.833\u20130.934; P &amp;lt; 0.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The CAC score helps in further risk stratification in patients with HeFH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oead046","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T17:02:48Z","timestamp":1683133368000},"source":"Crossref","is-referenced-by-count":12,"title":["Coronary artery calcium among patients with heterozygous familial hypercholesterolaemia"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-1809","authenticated-orcid":false,"given":"Hayato","family":"Tada","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University , 13-1 Takara-machi, Kanazawa, 920-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuko","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University , 13-1 Takara-machi, Kanazawa, 920-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Yamagami","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University , 13-1 Takara-machi, Kanazawa, 920-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6647-8240","authenticated-orcid":false,"given":"Akihiro","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University , 13-1 Takara-machi, Kanazawa, 920-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nohara","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Ishikawa Prefectural Central Hospital , Kanazawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University , 13-1 Takara-machi, Kanazawa, 920-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University , 13-1 Takara-machi, Kanazawa, 920-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8219-7729","authenticated-orcid":false,"given":"Kenshi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University , 13-1 Takara-machi, Kanazawa, 920-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University , 13-1 Takara-machi, Kanazawa, 920-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Takamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University , 13-1 Takara-machi, Kanazawa, 920-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5759-1353","authenticated-orcid":false,"given":"Masa-aki","family":"Kawashiri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kaga Medical Center , Kaga , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"2023051312201080900_oead046-B1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5551\/jat.RV16008","article-title":"Half a century tales of familial hypercholesterolemia (FH) in Japan","volume":"24","author":"Mabuchi","year":"2017","journal-title":"J Atheroscler Thromb"},{"key":"2023051312201080900_oead046-B2","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.jacc.2021.09.004","article-title":"Familial hypercholesterolemia: JACC focus seminar 4\/4","volume":"78","author":"Brandts","year":"2021","journal-title":"J Am Coll 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