{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T14:19:04Z","timestamp":1782569944644,"version":"3.54.5"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"publisher","award":["20K17087"],"award-info":[{"award-number":["20K17087"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grant-in-Aid for Scientific Research","award":["20K08476"],"award-info":[{"award-number":["20K08476"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Left ventricular (LV) global longitudinal strain (GLS) (LV-GLS) is a strong and independent predictor of outcomes in patients with immunoglobulin light-chain (AL) cardiac amyloidosis. This study was performed to investigate whether right ventricular (RV) GLS (RV-GLS) provides prognostic information in patients with AL amyloidosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Among 74 patients who were diagnosed with AL cardiac amyloidosis at Kumamoto University Hospital from December 2005 to December 2022, 65 patients who had enough information for two-dimensional speckle tracking imaging and did not receive chemotherapy before the diagnosis of cardiac amyloidosis were retrospectively analysed. During a median follow-up of 359 days, 29 deaths occurred. In two-dimensional echocardiographic findings, LV-GLS, left atrium reservoir strain (LASr), and RV-GLS were significantly lower in the all-cause death group than in the survival group (LV-GLS: 8.9 \u00b1 4.2 vs. 11.7 \u00b1 3.9, P &amp;lt; 0.01; LASr: 9.06 \u00b1 7.28 vs. 14.09 \u00b1 8.32, P &amp;lt; 0.05; RV-GLS: 12.0 \u00b1 5.1 vs. 16.8 \u00b1 4.0, P &amp;lt; 0.01). Multivariable Cox proportional hazard analysis showed RV-GLS was significantly and independently associated with all-cause death in patients with AL cardiac amyloidosis (hazard ratio 0.85; 95% confidence interval, 0.77\u20130.94; P &amp;lt; 0.01). Receiver operating characteristic analysis showed that the area under the curve of RV-GLS for all-cause death was 0.774 and that the best cut-off value of RV-GLS was 14.5% (sensitivity, 75%; specificity, 72%). In the Kaplan\u2013Meier analysis, patients with AL cardiac amyloidosis who had low RV-GLS (&amp;lt;14.5%) had a significantly higher probability of all-cause death (P &amp;lt; 0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>RV-GLS has prognostic value in patients with AL cardiac amyloidosis and provides greater prognostic power than LV-GLS and LASr.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oead048","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T23:58:46Z","timestamp":1683763126000},"source":"Crossref","is-referenced-by-count":11,"title":["Prognostic value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4086-7541","authenticated-orcid":false,"given":"Hiroki","family":"Usuku","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Kumamoto University Hospital , 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 , Japan"},{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 , Japan"},{"name":"Center of Metabolic Regulation of Healthy Aging, Kumamoto University Faculty of Life Sciences , 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 , Japan"},{"name":"Center of Metabolic Regulation of Healthy Aging, Kumamoto University Faculty of Life Sciences , 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0960-0339","authenticated-orcid":false,"given":"Daisuke","family":"Sueta","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 , Japan"},{"name":"Center of Metabolic Regulation of Healthy Aging, Kumamoto University Faculty of Life Sciences , 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoko","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Kumamoto University Hospital , 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 , 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1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6201-0701","authenticated-orcid":false,"given":"Seiji","family":"Takashio","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 , Japan"},{"name":"Center of Metabolic Regulation of Healthy Aging, Kumamoto University Faculty of Life Sciences , 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawara","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Hematology, Rheumatology, and Infectious Diseases, Graduate School of Medical Science, Kumamoto University , 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556 , 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