{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T12:08:07Z","timestamp":1770466087857,"version":"3.49.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["82150006"],"award-info":[{"award-number":["82150006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>There is still no non-invasive septal reduction therapy for patients with hypertrophic obstructive cardiomyopathy (HOCM). This study aimed to investigate the feasibility, safety, and efficacy of stereotactic body radiotherapy (SBRT) in patients with drug-refractory symptomatic HOCM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The radiation target of ventricular septum was determined by multiple anatomical imaging. Stereotactic body radiotherapy was performed with standard techniques. Patients were treated with a single fraction of 25\u2005Gy, followed up at 1, 3, 6, and 12\u2005months by clinical visit. Five patients were enrolled and completed the 12\u2005months follow-up. The mean radioablation time was 21.6\u2005min, and the mean target volume was 10.5\u2005cm3. All five patients survived and showed improvements in symptoms after SBRT. At 12\u2005months post-SBRT, the echocardiography-derived left ventricular outflow tract gradient decreased from 88\u2005mmHg (range, 63\u2013105) to 52\u2005mmHg (range, 36\u201366) at rest and from 101\u2005mmHg (range, 72\u2013121) to 74\u2005mmHg (range, 65\u2013100) after Valsalva. The end-diastolic thickness of the targeted septum reduced from 23.7\u2005mm (range, 20.3\u201329) to 22.4\u2005mm (range, 19.7\u201326.5); 6\u2005min walking distance increased from 190.4\u2005m (range, 50\u2013370) to 412.0\u2005m (range, 320\u2013480). All patients presented with new fibrosis in the irradiated septum area. No radiation-related complications were observed during SBRT and up to 12\u2005months post procedure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The current study suggests that SBRT might be a feasible radioablation therapeutic option for patients with drug-refractory symptomatic HOCM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration<\/jats:title>\n                  <jats:p>ClinicalTrials.gov Identifier: NCT04686487<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oead052","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T23:37:25Z","timestamp":1684885045000},"source":"Crossref","is-referenced-by-count":4,"title":["Septal radioablation therapy for patients with hypertrophic obstructive cardiomyopathy: first-in-human study"],"prefix":"10.1093","volume":"3","author":[{"given":"Xuping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University , 139 Mid-Renmin Road, Changsha, Hunan 410011 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaowei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University , 139 Mid-Renmin Road, Changsha, Hunan 410011 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Radiology Department, The Second Xiangya Hospital, Central South University , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawen","family":"Gao","sequence":"additional","affiliation":[{"name":"Oncology Department, The Second Xiangya Hospital, Central South University 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianling","family":"Liu","sequence":"additional","affiliation":[{"name":"Oncology Department, The Second Xiangya Hospital, Central South University , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhong","family":"Hu","sequence":"additional","affiliation":[{"name":"Oncology Department, The Second Xiangya Hospital, Central South University , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Ma","sequence":"additional","affiliation":[{"name":"Oncology Department, The Second Xiangya Hospital, Central South University , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Radiology Department, The Second Xiangya Hospital, Central South University , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Anesthesiology Department, Hunan Provincial People\u2019s Hospital , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University , 139 Mid-Renmin Road, Changsha, Hunan 410011 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University , 139 Mid-Renmin Road, Changsha, Hunan 410011 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central 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