{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T20:38:29Z","timestamp":1776976709403,"version":"3.51.4"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,2]]},"DOI":"10.1093\/ehjopen\/oead059","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T20:06:39Z","timestamp":1686341199000},"source":"Crossref","is-referenced-by-count":4,"title":["Exploring the link between Gilbert\u2019s syndrome and atherosclerotic cardiovascular disease: insights from a subpopulation-based analysis of over one million individuals"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-8037","authenticated-orcid":false,"given":"Uri","family":"Kartoun","sequence":"first","affiliation":[{"name":"Center for Computational Health, IBM Research , 314 Main St., Cambridge, MA 02142 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akl C","family":"Fahed","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA , USA"},{"name":"Division of Cardiology, Massachusetts General Hospital , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinwan","family":"Kany","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pulkit","family":"Singh","sequence":"additional","affiliation":[{"name":"Data Sciences Platform, Broad Institute of MIT and Harvard , Cambridge, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaan","family":"Khurshid","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA , USA"},{"name":"Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniruddh P","family":"Patel","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA , USA"},{"name":"Division of Cardiology, Massachusetts General Hospital , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Batra","sequence":"additional","affiliation":[{"name":"Data Sciences Platform, Broad Institute of MIT and Harvard , Cambridge, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Philippakis","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit V","family":"Khera","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA , USA"},{"name":"Division of Cardiology, Massachusetts General Hospital , Boston, MA , USA"},{"name":"Verve Therapeutics , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven A","family":"Lubitz","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA , USA"},{"name":"Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick T","family":"Ellinor","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard , Cambridge, MA , USA"},{"name":"Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibha","family":"Anand","sequence":"additional","affiliation":[{"name":"Center for Computational Health, IBM Research , 314 Main St., Cambridge, MA 02142 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenney","family":"Ng","sequence":"additional","affiliation":[{"name":"Center for Computational Health, IBM Research , 314 Main St., Cambridge, MA 02142 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"2023062612153683900_oead059-B1","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1056\/NEJM199511023331812","article-title":"Gilbert\u2019s syndrome \u2013 a legitimate genetic anomaly?","volume":"333","author":"Schmid","year":"1995","journal-title":"N Engl J Med"},{"key":"2023062612153683900_oead059-B2","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1056\/NEJM199511023331802","article-title":"The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert\u2019s syndrome","volume":"333","author":"Bosma","year":"1995","journal-title":"N Engl J Med"},{"key":"2023062612153683900_oead059-B3","doi-asserted-by":"crossref","first-page":"H429","DOI":"10.1152\/ajpheart.00417.2017","article-title":"Bilirubin acts as a multipotent guardian of cardiovascular integrity: more than just a radical idea","volume":"315","author":"Bulmer","year":"2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2023062612153683900_oead059-B4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.atherosclerosis.2009.02.010","article-title":"Low serum bilirubin concentration is associated with coronary artery calcification (CAC)","volume":"206","author":"Tanaka","year":"2009","journal-title":"Atherosclerosis"},{"key":"2023062612153683900_oead059-B5","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007792","article-title":"Bilirubin is inversely associated with cardiovascular disease among HIV-positive and HIV-negative individuals in VACS (Veterans Aging Cohort Study)","volume":"7","author":"Marconi","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2023062612153683900_oead059-B6","doi-asserted-by":"crossref","first-page":"12542","DOI":"10.1038\/s41598-022-16615-3","article-title":"Prediction performance and fairness heterogeneity in cardiovascular risk models","volume":"12","author":"Kartoun","year":"2022","journal-title":"Sci Rep"},{"key":"2023062612153683900_oead059-B7","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1161\/01.cir.0000437741.48606.98","article-title":"2013 ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"129","author":"Goff","year":"2014","journal-title":"Circulation"},{"key":"2023062612153683900_oead059-B8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v042.i07","article-title":"Multivariate and propensity score matching software with automated balance optimization: the matching package for R","volume":"42","author":"Sekhon","year":"2011","journal-title":"J Stat Softw"},{"key":"2023062612153683900_oead059-B9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jacc.2016.10.060","article-title":"Comparison of propensity score methods and covariate adjustment: evaluation in 4 cardiovascular studies","volume":"69","author":"Elze","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2023062612153683900_oead059-B10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0021-9150(01)00601-3","article-title":"Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels","volume":"160","author":"V\u00edtek","year":"2002","journal-title":"Atherosclerosis"}],"container-title":["European Heart Journal Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjopen\/advance-article-pdf\/doi\/10.1093\/ehjopen\/oead059\/50565258\/oead059.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjopen\/article-pdf\/3\/3\/oead059\/50702000\/oead059.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjopen\/article-pdf\/3\/3\/oead059\/50702000\/oead059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T12:57:22Z","timestamp":1687784242000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjopen\/article\/doi\/10.1093\/ehjopen\/oead059\/7193306"}},"subtitle":[],"editor":[{"given":"Magnus","family":"B\u00e4ck","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjopen\/oead059","relation":{},"ISSN":["2752-4191"],"issn-type":[{"value":"2752-4191","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5]]},"published":{"date-parts":[[2023,5]]},"article-number":"oead059"}}