{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:36:59Z","timestamp":1774924619987,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Pulmonary hypertension (PH) is a complex clinical condition, and left heart disease is the leading cause. Little is known about the epidemiology and prognosis of combined post- and pre-capillary PH (CpcPH).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This retrospective analysis of the Swiss PH Registry included incident patients with CpcPH registered from January 2001 to June 2019 at 13 Swiss hospitals. Patient baseline characteristics [age, sex, mean pulmonary artery pressure (mPAP), pulmonary artery wedge pressure (PAWP), pulmonary vascular resistance (PVR), and risk factors, including World Health Organization (WHO)-functional class (FC), 6\u2005min walk distance (6MWD), and N-terminal pro-brain natriuretic peptide (NT-proBNP), treatment, days of follow-up, and events (death or loss to follow-up) at last visit] were analysed by Kaplan\u2013Meier and Cox regression analyses. Two hundred and thirty-one patients (59.3% women, age 65 \u00b1 12 years, mPAP 48 \u00b1 11\u2005mmHg, PAWP 21 \u00b1 5\u2005mmHg, PVR 7.2 \u00b1 4.8 WU) were included. Survival analyses showed a significantly longer survival for women [hazard ratio (HR) 0.58 (0.38\u20130.89); P = 0.01] and a higher mortality risk for mPAP &amp;gt; 46\u2005mmHg [HR 1.58 (1.03\u20132.43); P = 0.04] but no association with age or PVR. Patients stratified to high risk according to four-strata risk assessment had an increased mortality risk compared with patients stratified to low-intermediate risk [HR 2.44 (1.23\u20134.84); P = 0.01]. A total of 46.8% of CpcPH patients received PH-targeted pharmacotherapy; however, PH-targeted medication was not associated with longer survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Among patients with CpcPH, women and patients with an mPAP \u226446\u2005mmHg survived longer. Furthermore, risk stratification by using non-invasively assessed risk factors, such as WHO-FC, 6MWD, and NT-proBNP, as proposed for pulmonary arterial hypertension, stratified survival in CpcPH, and might be helpful in the management of these patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oead069","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T07:51:48Z","timestamp":1688370708000},"source":"Crossref","is-referenced-by-count":4,"title":["Long-term outcome of patients with combined post- and pre-capillary pulmonary hypertension"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7431-1643","authenticated-orcid":false,"given":"Anna","family":"Titz","sequence":"first","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich , R\u00e4mistrasse 100, Zurich 8091 , Switzerland"},{"name":"Department of Pulmonology, University of Zurich , Zurich , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich , R\u00e4mistrasse 100, Zurich 8091 , Switzerland"},{"name":"Department of Pulmonology, University of Zurich , Zurich , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Appenzeller","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich , R\u00e4mistrasse 100, Zurich 8091 , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich , R\u00e4mistrasse 100, Zurich 8091 , Switzerland"},{"name":"Department of Pulmonology, University of Zurich , Zurich , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon R","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich , R\u00e4mistrasse 100, Zurich 8091 , Switzerland"},{"name":"Department of Pulmonology, University of Zurich , Zurich , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Tamm","sequence":"additional","affiliation":[{"name":"Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel , Basel , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei M","family":"Darie","sequence":"additional","affiliation":[{"name":"Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital Basel , Basel , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina A","family":"Guler","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Department for BioMedical Research, Inselspital, Bern University Hospital, University of Bern , Bern , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John-David","family":"Aubert","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Lausanne , Lausanne , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Lador","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Geneva , Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Stricker","sequence":"additional","affiliation":[{"name":"Department of Angiology, Ospedale La Carit\u00e0 , Locarno , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Fellrath","sequence":"additional","affiliation":[{"name":"Service of Pulmonology, Hospital Neuch\u00e2telois , Neuch\u00e2tel , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Pohle","sequence":"additional","affiliation":[{"name":"Lung Center, Cantonal Hospital St Gallen , St Gallen , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Lichtblau","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich , R\u00e4mistrasse 100, Zurich 8091 , Switzerland"},{"name":"Department of Pulmonology, University of Zurich , Zurich , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-5022","authenticated-orcid":false,"given":"Silvia","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University Hospital Zurich , R\u00e4mistrasse 100, Zurich 8091 , Switzerland"},{"name":"Department of Pulmonology, University of Zurich , Zurich , 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