{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:50:20Z","timestamp":1753876220737,"version":"3.41.2"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim was to study pregnancy outcomes in women with coarctation of the aorta (CoA) and associations to hypertensive disorders of pregnancy. Maternal morbidity and mortality are higher in women with heart disease and pre-eclampsia. Chronic hypertension, frequently encountered in CoA, is a risk factor for pre-eclampsia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Clinical data from the National Unit for Pregnancy and Heart Disease database was reviewed for pregnant women with CoA from 2008 to 2021. The primary outcome was hypertensive pregnancy disorders. The secondary outcomes were other cardiovascular, obstetric, and foetal complications. Seventy-six patients were included, with a total of 87 pregnancies. Seventeen (20%) patients were treated for chronic hypertension before pregnancy. Fifteen (20%) patients developed pre-eclampsia, and 5 (7%) had pregnancy-induced hypertension. Major adverse cardiac events developed in four (5%) patients, with no maternal or foetal mortality. Maternal age at first pregnancy [odds ratio (OR) 1.37], body mass index before first pregnancy (OR 1.77), and using acetylsalicylic acid from the first trimester (OR 0.22) were statistically significantly associated with pre-eclampsia. At follow-up (median) 8 years after pregnancy, 29 (38%) patients had anti-hypertensive treatment, an increase of 16% compared to pre-pregnancy. Five (7%) patients had progression of aorta ascendens dilatation to &amp;gt;40\u2005mm, seven (9%) had an upper to lower systolic blood pressure gradient &amp;gt;20 mmHg, and six (8%) had received CoA re-intervention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pre-eclampsia occurred in 20% of women with CoA in their first pregnancy. All pre-eclamptic patients received adequate anti-hypertensive treatment. All CoA patients were provided multi-disciplinary management, including cardiologic follow-up, to optimize maternal\u2013foetal outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oead072","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T13:38:45Z","timestamp":1690465125000},"source":"Crossref","is-referenced-by-count":6,"title":["High prevalence of pre-eclampsia in women with coarctation of the aorta"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2320-3930","authenticated-orcid":false,"given":"Lasse","family":"Gronningsaeter","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Division of Emergencies and Critical Care Medicine, Oslo University Hospital, Rikshospitalet, Postboks 4950 Nydalen, Oslo N-0424 , Norway"},{"name":"Faculty of Medicine, Oslo University Hospital , Oslo , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldrid","family":"Langesaeter","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Division of Emergencies and Critical Care Medicine, Oslo University Hospital, Rikshospitalet, Postboks 4950 Nydalen, Oslo N-0424 , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingvil Krarup","family":"S\u00f8rbye","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Division of Obstetrics and Gynecology, Oslo University Hospital, Rikshospitalet, Oslo N-0424, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Quattrone","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Heart, Lung, and Vessel diseases, Oslo University Hospital, Rikshospitalet, Oslo N-0424, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibeke Marie","family":"Almaas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Heart, Lung, and Vessel diseases, Oslo University Hospital, Rikshospitalet, Oslo N-0424, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge","family":"Skulstad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Heart, Lung, and Vessel diseases, Oslo University Hospital, Rikshospitalet, Oslo N-0424, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo , Oslo , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette-Elise","family":"Estensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Heart, Lung, and Vessel diseases, Oslo University Hospital, Rikshospitalet, Oslo N-0424, 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