{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:19:42Z","timestamp":1790014782502,"version":"4.0.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenbergs Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001858","name":"Vinnova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012324","name":"University Hospitals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Dilation of the ascending aorta (AA) is often asymptomatic until a life-threatening dissection or rupture occurs. An overall increase in the use of thoracic imaging has enabled early and sometimes incidental identification of AA dilation. Still, the prevalence and determinants of AA dilation remain to be clarified. The aim was to identify and characterize persons with AA dilation in a middle-aged Swedish population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We used the Swedish CardioPulmonary BioImage Study Link\u00f6ping (n = 5058, age 50\u201365 years) to identify cases with AA diameter \u2265 40\u2005mm on coronary computed tomography angiography (CCTA) or chest computed tomography. Age- and gender-matched individuals with AA diameter &amp;lt; 40\u2005mm served as controls. Echocardiography, blood pressure (BP) measurements (office and home), pulse wave velocity (PWV), coronary artery calcification (CAC), CCTA-detected coronary atherosclerosis, and carotid ultrasound were used to characterize these subjects. We identified 70 cases (mean AA diameter 44\u2005mm, 77% men) and matched these to 146 controls (mean AA diameter 34\u2005mm). Bicuspid aortic valve and aortic valve dysfunction were more common in cases than in controls (8% vs. 0% and 39% vs. 11%, respectively). Both office and home BP levels were significantly higher among cases. Also, high PWV (&amp;gt;10\u2005m\/s) levels were more common in cases (33% vs. 17%). Neither CAC scores nor prevalence or burden of atherosclerosis in coronary and carotid arteries differed between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The prevalence of dilated AA was 1.4% and showed positive associations with male gender, aortic valve pathology, and diastolic BP, though not with subclinical atherosclerosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oead085","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:56:02Z","timestamp":1693011362000},"source":"Crossref","is-referenced-by-count":13,"title":["Prevalence and determinants of dilated ascending aorta in a Swedish population: a case\u2013control study"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2608-2062","authenticated-orcid":false,"given":"Eva","family":"Swahn","sequence":"first","affiliation":[{"name":"Department of Cardiology, Link\u00f6ping University Hospital , Link\u00f6ping ,","place":["Sweden"]},{"name":"Department of Health, Medicine and Caring Sciences, Faculty of Medicine, Link\u00f6ping University , Link\u00f6ping ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Lekedal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Link\u00f6ping University Hospital , Link\u00f6ping ,","place":["Sweden"]},{"name":"Department of Health, Medicine and Caring Sciences, Faculty of Medicine, Link\u00f6ping University , Link\u00f6ping ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Engvall","sequence":"additional","affiliation":[{"name":"Department of Health, Medicine and Caring Sciences, Faculty of Medicine, Link\u00f6ping University , Link\u00f6ping ,","place":["Sweden"]},{"name":"Department of Clinical Physiology, Link\u00f6ping University , Link\u00f6ping ,","place":["Sweden"]},{"name":"CMIV, Center for Medical Image Science and Viusalization, Link\u00f6ping University , Link\u00f6ping ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik H","family":"Nystr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Health, Medicine and Caring Sciences, Faculty of Medicine and Health Sciences, Link\u00f6ping University , Link\u00f6ping ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Jonasson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Link\u00f6ping University Hospital , Link\u00f6ping ,","place":["Sweden"]},{"name":"Department of Health, Medicine and Caring Sciences, Faculty of Medicine, Link\u00f6ping University , Link\u00f6ping ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"2025012214061168000_oead085-B1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0003-4975(01)03236-2","article-title":"Yearly rupture or dissection rates for thoracic aortic aneurysms: simple prediction based on size","volume":"73","author":"Davies","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"2025012214061168000_oead085-B2","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00330-019-06433-z","article-title":"High prevalence of ascending aortic dilatation in a consecutive coronary CT angiography patient population","volume":"30","author":"Kauhanen","year":"2020","journal-title":"Eur Radiol"},{"key":"2025012214061168000_oead085-B3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/heartjnl-2019-315320","article-title":"Sex-specific distributions and determinants of thoracic aortic diameters in the elderly","volume":"106","author":"Bons","year":"2020","journal-title":"Heart"},{"key":"2025012214061168000_oead085-B4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/RCT.0000000000000167","article-title":"Prevalence and significance of incidentally noted dilation of the ascending aorta on routine chest computed tomography in older patients","volume":"39","author":"Benedetti","year":"2015","journal-title":"J Comput Assist Tomogr"},{"key":"2025012214061168000_oead085-B5","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.jacc.2016.06.025","article-title":". Risk of aortic dissection in the moderately dilated ascending aorta","volume":"68","author":"Kim","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2025012214061168000_oead085-B6","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/ejcts\/ezx024","article-title":"Natural history of moderately dilated tubular ascending aorta: implications for determining the optimal imaging interval","volume":"51","author":"Park","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"2025012214061168000_oead085-B7","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","article-title":"2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. 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Clinical, laboratory, and transesophageal echocardiographic correlates of thoracic aortic dimensions in the population with implications for thoracic aortic aneurysm formation","volume":"42","author":"Agmon","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2025012214061168000_oead085-B28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.atherosclerosis.2013.10.035","article-title":"Advanced atherosclerosis is associated with increased medial degeneration in sporadic ascending aortic aneurysms","volume":"232","author":"Albini","year":"2014","journal-title":"Atherosclerosis"},{"key":"2025012214061168000_oead085-B29","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ijcard.2011.05.039","article-title":"Body-surface adjusted aortic reference diameters for improved identification of patients with thoracic aortic aneurysms: results from the population-based Heinz Nixdorf Recall study","volume":"163","author":"Kalsch","year":"2013","journal-title":"Int J Cardiol"},{"key":"2025012214061168000_oead085-B30","doi-asserted-by":"crossref","first-page":"e003792","DOI":"10.1161\/JAHA.116.003792","article-title":"Thoracic aortic aneurysm growth: role of sex and aneurysm etiology","volume":"6","author":"Cheung","year":"2017","journal-title":"J Am Heart Assoc"}],"container-title":["European Heart Journal Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjopen\/advance-article-pdf\/doi\/10.1093\/ehjopen\/oead085\/51267661\/oead085.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjopen\/article-pdf\/3\/5\/oead085\/51760154\/oead085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjopen\/article-pdf\/3\/5\/oead085\/51760154\/oead085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T14:06:29Z","timestamp":1737554789000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjopen\/article\/doi\/10.1093\/ehjopen\/oead085\/7251460"}},"subtitle":[],"editor":[{"given":"Patrizio","family":"Lancellotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,8,25]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9,4]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjopen\/oead085","relation":{},"ISSN":["2752-4191"],"issn-type":[{"value":"2752-4191","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9]]},"published":{"date-parts":[[2023,8,25]]},"article-number":"oead085"}}