{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:50:27Z","timestamp":1753876227902,"version":"3.41.2"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>We analysed longitudinal blood pressure (BP) data from hypertensive obstructive sleep apnoea (OSA) patients in the European Sleep Apnea Database cohort. The study investigated the interaction between positive airway pressure (PAP)-induced BP change and antihypertensive treatment (AHT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Hypertensive patients with AHT [monotherapy\/dual therapy n = 1283\/652, mean age 59.6 \u00b1 10.7\/60.6 \u00b1 10.3 years, body mass index (BMI) 34.2 \u00b1 6.5\/34.8 \u00b1 7.0\u2005kg\/m2, apnoea\u2013hypopnoea index 46 \u00b1 25\/46 \u00b1 24 n\/h, proportion female 29\/26%, respectively] started PAP treatment. Office BP at baseline and 2- to 36-month follow-up were assessed. The interaction between AHT drug classes and PAP on BP was quantified and the influences of age, gender, BMI, co-morbidities, BP at baseline, and study site were evaluated. Following PAP treatment (daily usage, 5.6 \u00b1 1.6\/5.7 \u00b1 1.9\u2005h\/day), systolic BP was reduced by \u22123.9 \u00b1 15.5\/\u22122.8 \u00b1 17.7\u2005mmHg in mono\/dual AHT and diastolic BP by \u22123.0 \u00b1 9.8\/\u22122.7 \u00b1 10.8\u2005mmHg, respectively, all P &amp;lt; 0.0001. Systolic and diastolic BP control was improved following PAP treatment (38\/35% to 54\/46% and 67\/67% to 79\/74%, mono\/dual AHT, respectively). PAP treatment duration predicted a larger BP improvement in the monotherapy group. Intake of renin\u2013angiotensin blockers [angiotensin converting enzyme inhibitor (ACEI)\/angiotensin receptor blocker (ARB)] alone or in any AHT combination was associated with better BP control. The AHT-dependent BP improvement was independent of confounders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In this pan-European OSA patient cohort, BP control improved following initiation of PAP. Longer PAP treatment duration, was associated with a favourable effect on BP. Our study suggests that ACEI\/ARB, alone or in combination with other drug classes, provides a particularly strong reduction of BP and better BP control when combined with PAP in OSA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oead109","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T20:59:43Z","timestamp":1697576383000},"source":"Crossref","is-referenced-by-count":4,"title":["Blood pressure control in hypertensive sleep apnoea patients of the European Sleep Apnea Database cohort - effects of positive airway pressure and antihypertensive medication"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5786-7938","authenticated-orcid":false,"given":"Sven","family":"Svedmyr","sequence":"first","affiliation":[{"name":"Department of Sleep Medicine, Sahlgrenska University Hospital , Bl\u00e5 str\u00e5ket 5, 413 45 Gothenburg , Sweden"},{"name":"Center for Sleep and Vigilance Disorders, Sahlgrenska Academy, Gothenburg University , Medicinaregatan 8B , Box 421, 405 30 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7190-394X","authenticated-orcid":false,"given":"Jan","family":"Hedner","sequence":"additional","affiliation":[{"name":"Department of Sleep Medicine, Sahlgrenska University Hospital , Bl\u00e5 str\u00e5ket 5, 413 45 Gothenburg , Sweden"},{"name":"Center for Sleep and Vigilance Disorders, Sahlgrenska Academy, Gothenburg University , Medicinaregatan 8B , Box 421, 405 30 Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien","family":"Bailly","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, INSERM HP2 (U1042) and Grenoble University Hospital , Grenoble , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Fanfulla","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Medicina del Sonno, Istituto Scientifico di Pavia IRCCS , Pavia , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Hein","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center, St.Adolf Stift , Reinbeck , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Sleep Center, IRCCS Istituto Auxologico Italiano , Milan , Italy"},{"name":"Department of Medicine and Surgery, University of Milano-Bicocca , Milan , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ondrej","family":"Ludka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Brno , Brno , Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Mihaicuta","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Precision Medicine and Pharmacy, \u2018Victor Babes\u2019 University of Medicine and Pharmacy , Timisoara , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9402-7439","authenticated-orcid":false,"given":"Gianfranco","family":"Parati","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Sleep Center, IRCCS Istituto Auxologico Italiano , Milan , Italy"},{"name":"Department of Medicine and Surgery, University of Milano-Bicocca , Milan , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3252-6694","authenticated-orcid":false,"given":"Athanasia","family":"Pataka","sequence":"additional","affiliation":[{"name":"Respiratory Failure Unit, G. 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