{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:39:57Z","timestamp":1774312797009,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"John Hunter Hospital Charitable Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Cardiac catheterization procedures are typically performed with local anaesthetic and proceduralist guided sedation. Various fasting regimens are routinely implemented prior to these procedures, noting the absence of prospective evidence, aiming to reduce aspiration risk. However, there are additional risks from fasting including patient discomfort, intravascular volume depletion, stimulus for neuro-cardiogenic syncope, glycaemic outcomes, and unnecessary fasting for delayed\/cancelled procedures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This is an investigator-initiated, multicentre, randomized trial with a prospective, open-label, blinded endpoint (PROBE) assessment based in New South Wales, Australia. Patients will be randomized 1:1 to fasting (6\u2005h solid food and 2\u2005h clear liquids) or to no fasting requirements. The primary outcome will be a composite of hypotension, hyperglycaemia, hypoglycaemia, and aspiration pneumonia. Secondary outcomes will include patient satisfaction, contrast-induced nephropathy, new intensive care admission, new non-invasive or invasive ventilation requirement post procedure, and 30-day mortality and readmission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This is a pragmatic and clinically relevant randomised trial designed to compare fasting verse no fasting prior to cardiac catheterisation procedures. Routine fasting may not reduce peri-procedural adverse events in this setting.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oead111","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T20:59:33Z","timestamp":1697576373000},"source":"Crossref","is-referenced-by-count":8,"title":["Safety and care of no fasting prior to catheterization laboratory procedures: a non-inferiority randomized control trial protocol (SCOFF trial)"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-4503","authenticated-orcid":false,"given":"David","family":"Ferreira","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, John Hunter Hospital , Lookout Road, Newcastle 2305 , Australia"},{"name":"School of Medicine and Public Health, University of Newcastle , University Drive, Newcastle 2308 , Australia"},{"name":"Hunter Medical Research Institute , Kookaburra Circuit, Newcastle 2305 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Hardy","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, John Hunter Hospital , Lookout Road, Newcastle 2305 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Will","family":"Meere","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gosford Hospital , 75 Holden Street, Gosford 2250 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lloyd","family":"Butel-Simoes","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, John Hunter Hospital , Lookout Road, Newcastle 2305 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"McGee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tamworth Rural Referral Hospital , Dean Street, Tamworth 2340 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Calvary Mater Hospital , 20 Edith Street, Newcastle 2298 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Healey","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, John Hunter Hospital , Lookout Road, Newcastle 2305 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tamworth Rural Referral Hospital , Dean Street, Tamworth 2340 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Oldmeadow","sequence":"additional","affiliation":[{"name":"Hunter Medical Research Institute , Kookaburra Circuit, Newcastle 2305 , 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Lookout Road, Newcastle 2305 , Australia"},{"name":"School of Medicine and Public Health, University of Newcastle , University Drive, Newcastle 2308 , Australia"},{"name":"Hunter Medical Research Institute , Kookaburra Circuit, Newcastle 2305 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Boyle","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, John Hunter Hospital , Lookout Road, Newcastle 2305 , Australia"},{"name":"School of Medicine and Public Health, University of Newcastle , University Drive, Newcastle 2308 , Australia"},{"name":"Hunter Medical Research Institute , Kookaburra Circuit, Newcastle 2305 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"2024091718040155400_oead111-B1","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1161\/CIR.0000000000000996","article-title":"Evidence-based practices in the cardiac catheterization laboratory: a scientific statement from the American Heart Association","volume":"144","author":"Bangalore","year":"2021","journal-title":"Circulation"},{"key":"2024091718040155400_oead111-B2","first-page":"CD004423","article-title":"Preoperative fasting for adults to prevent perioperative complications","volume":"4","author":"Brady","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"2024091718040155400_oead111-B3","doi-asserted-by":"crossref","first-page":"101179","DOI":"10.1016\/j.cpcardiol.2022.101179","article-title":"Is NPO (Nil Per Os) order helping or hindering elective cardiac 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