{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:11:54Z","timestamp":1788412314332,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Academic Clinical Fellows"},{"name":"Wellcome Trust PhD Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Cardiogenic shock remains the leading cause of death in patients hospitalized with acute myocardial infarction. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used in the treatment of infarct-related cardiogenic shock. However, there is limited evidence regarding its beneficial impact on mortality. The aim of this study was to systematically review studies reporting the impact of VA-ECMO on mortality in patients with acute myocardial infarction complicated by cardiogenic shock.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A comprehensive search of medical databases (Cochrane Register and PubMed) was conducted. Studies that reported mortality outcomes in patients treated with VA-ECMO for infarct-related cardiogenic shock were included. The database search yielded 1194 results, of which 11 studies were included in the systematic review. Four of these studies, with a total of 586 patients, were randomized controlled trials and were included in the meta-analysis. This demonstrated that there was no significant difference in 30-day all-cause mortality with the use of VA-ECMO compared with standard medical therapy [odds ratio (OR) 0.91; 95% confidence interval (CI) 0.65\u20131.27]. Meta-analysis of two studies showed that VA-ECMO was associated with a significant reduction in 12-month all-cause mortality (OR 0.31; 95% CI 0.11\u20130.86). Qualitative synthesis of the observational studies showed that age, serum creatinine, serum lactate, and successful revascularization are independent predictors of mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Veno-arterial extracorporeal membrane oxygenation does not improve 30-day all-cause mortality in patients with cardiogenic shock following acute myocardial infarction; however, there may be significant reduction in all-cause mortality at 12 months. Further studies are needed to delineate the potential benefit of VA-ECMO in long-term outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Registration<\/jats:title>\n                  <jats:p>The protocol was registered in the PROSPERO International Prospective Register of Systematic Reviews (ID: CRD42023461740).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeae003","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T14:09:14Z","timestamp":1705673354000},"source":"Crossref","is-referenced-by-count":21,"title":["The impact of extracorporeal membrane oxygenation on mortality in patients with cardiogenic shock post-acute myocardial infarction: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1163-9710","authenticated-orcid":false,"given":"Sophie","family":"Paddock","sequence":"first","affiliation":[{"name":"Cardiology Department, Norfolk and Norwich University Hospital , Colney Lane , Norwich NR4 7UY, UK"},{"name":"Norwich Medical School, University of East Anglia , Norwich, NR4 7TJ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Meng","sequence":"additional","affiliation":[{"name":"Cardiology Department, Norfolk and Norwich University Hospital , Colney Lane , Norwich NR4 7UY, UK"},{"name":"Norwich Medical School, University of East Anglia , Norwich, NR4 7TJ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Johnson","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia , Norwich, NR4 7TJ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia , Norwich, NR4 7TJ , UK"},{"name":"Cardiology Department, Cambridge University Hospital , Cambridge , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Tsampasian","sequence":"additional","affiliation":[{"name":"Cardiology Department, Norfolk and Norwich University Hospital , Colney Lane , Norwich NR4 7UY, UK"},{"name":"Norwich Medical School, University of East Anglia , Norwich, NR4 7TJ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-7752","authenticated-orcid":false,"given":"Vassilios","family":"Vassiliou","sequence":"additional","affiliation":[{"name":"Cardiology Department, Norfolk and Norwich University Hospital , Colney Lane , Norwich NR4 7UY, UK"},{"name":"Norwich Medical School, University of East Anglia , Norwich, NR4 7TJ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"2024022910043389600_oeae003-B1","doi-asserted-by":"crossref","first-page":"e000590","DOI":"10.1161\/JAHA.113.000590","article-title":"Trends in incidence, management, and outcomes of cardiogenic shock complicating ST-elevation myocardial infarction in the United States","volume":"3","author":"Kolte","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"2024022910043389600_oeae003-B2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/cce2.62","article-title":"Cardiogenic shock: current epidemiology and management","volume":"3","author":"Kataja","year":"2017","journal-title":"Contin Cardiol Educ"},{"key":"2024022910043389600_oeae003-B3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/2048872619894254","article-title":"Acute Cardiovascular Care Association position statement for the diagnosis and treatment of patients with acute myocardial infarction complicated by cardiogenic shock: a document of the Acute Cardiovascular Care Association of the European Society of Cardiology","volume":"9","author":"Zeymer","year":"2020","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"2024022910043389600_oeae003-B4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1056\/NEJM199908263410901","article-title":"Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK investigators. Should we emergently revascularize occluded coronaries for cardiogenic shock","volume":"341","author":"Hochman","year":"1999","journal-title":"N Engl J Med"},{"key":"2024022910043389600_oeae003-B5","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1093\/eurheartj\/ehz363","article-title":"Management of cardiogenic shock complicating myocardial infarction: an update 2019","volume":"40","author":"Thiele","year":"2019","journal-title":"Eur Heart J"},{"key":"2024022910043389600_oeae003-B6","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC guidelines for the management of acute coronary syndromes: developed by the task force on the management of acute coronary syndromes of the European Society of Cardiology (ESC)","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur Heart J"},{"key":"2024022910043389600_oeae003-B7","first-page":"CD007398","article-title":"Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock","volume":"2015","author":"Unverzagt","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2024022910043389600_oeae003-B8","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0140-6736(13)61783-3","article-title":"Intraaortic balloon pump in cardiogenic shock II (IABP-SHOCK II) trial investigators. Intra-aortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock (IABP-SHOCK II): final 12 month results of a randomised, open-label trial","volume":"382","author":"Thiele","year":"2013","journal-title":"Lancet"},{"key":"2024022910043389600_oeae003-B9","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.3390\/jcm11143955","article-title":"Impella versus venoarterial extracorporeal membrane oxygenation for acute myocardial infarction cardiogenic shock: a systematic review and meta-analysis","volume":"11","author":"Batchelor","year":"2022","journal-title":"J Clin Med"},{"key":"2024022910043389600_oeae003-B10","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1016\/j.jacc.2014.09.017","article-title":"2014 AHA\/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology\/American Heart Association task force on practice guidelines","volume":"64","author":"Amsterdam","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2024022910043389600_oeae003-B11","doi-asserted-by":"crossref","first-page":"e004905","DOI":"10.1161\/CIRCHEARTFAILURE.118.004905","article-title":"Venoarterial extracorporeal membrane oxygenation for cardiogenic shock and cardiac arrest","volume":"11","author":"Rao","year":"2018","journal-title":"Circ Heart Fail"},{"key":"2024022910043389600_oeae003-B12","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0140-6736(08)60958-7","article-title":"Cardiopulmonary resuscitation with assisted extracorporeal life-support versus conventional cardiopulmonary resuscitation in adults with in-hospital cardiac arrest: an observational study and propensity analysis","volume":"372","author":"Chen","year":"2008","journal-title":"Lancet"},{"key":"2024022910043389600_oeae003-B13","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1097\/CCM.0b013e31816f7cf7","article-title":"Outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation for refractory cardiogenic shock","volume":"35","author":"Combes","year":"2008","journal-title":"Crit Care Med"},{"key":"2024022910043389600_oeae003-B14","first-page":"E166","article-title":"Extra corporeal membrane oxygenation (ECMO) review of lifesaving technology","volume":"7","author":"Makdisi","year":"2015","journal-title":"J Thorac Dis"},{"key":"2024022910043389600_oeae003-B15","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guidelines for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"2024022910043389600_oeae003-B16","doi-asserted-by":"crossref","first-page":"482","DOI":"10.4244\/EIJ-D-23-00204","article-title":"Venoarterial extracorporeal membrane oxygenation or standard care in patients with cardiogenic shock complicating acute myocardial infarction: the multicentre, randomised EURO SHOCK trial","volume":"19","author":"Banning","year":"2023","journal-title":"EuroIntervention"},{"key":"2024022910043389600_oeae003-B17","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.jacc.2019.02.044","article-title":"Extracorporeal life support in cardiogenic shock complicating acute myocardial infarction","volume":"73","author":"Brunner","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2024022910043389600_oeae003-B18","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1007\/s00392-020-01778-8","article-title":"Outcome of patients treated with extracorporeal life support in cardiogenic shock complicating acute myocardial infarction: 1-year result from the ECLS-Shock study","volume":"110","author":"Lackermair","year":"2021","journal-title":"Clin Res Cardiol"},{"key":"2024022910043389600_oeae003-B19","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJMoa2307227","article-title":"Extracorporeal life support in infarct-related cardiogenic shock","volume":"389","author":"Thiele","year":"2023","journal-title":"N Engl JMedi"},{"key":"2024022910043389600_oeae003-B20","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/CIRCULATIONAHA.122.062949","article-title":"Extracorporeal membrane oxygenation in the therapy of cardiogenic shock: results of the ECMO-CS randomised clinical trial","volume":"147","author":"Ostadal","year":"2023","journal-title":"Circulation"},{"key":"2024022910043389600_oeae003-B21","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1002\/ccd.25871","article-title":"Extracorporeal membrane oxygenation support in acute coronary syndromes complicated by cardiogenic shock","volume":"86","author":"Esper","year":"2015","journal-title":"Catheter Cardiovasc Interv"},{"key":"2024022910043389600_oeae003-B22","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/MAT.0000000000001570","article-title":"Predictors of survival and ventricular recovery following acute myocardial infarction requiring extracorporeal membrane oxygenation","volume":"68","author":"Fried","year":"2022","journal-title":"ASAIO J"},{"key":"2024022910043389600_oeae003-B23","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.resuscitation.2012.01.037","article-title":"Efficacy of veno-arterial extracorporeal membrane oxygenation in acute myocardial infarction with cardiogenic shock","volume":"83","author":"Kim","year":"2012","journal-title":"Resuscitation"},{"key":"2024022910043389600_oeae003-B24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijcard.2023.03.037","article-title":"Veno-arterial extracorporeal membrane oxygenation for cardiogenic shock after acute myocardial infarction: insights from a French nationwide database","volume":"380","author":"Pozzi","year":"2023","journal-title":"Int J Cardiol"},{"key":"2024022910043389600_oeae003-B25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.athoracsur.2012.01.032","article-title":"Extracorporeal life support for cardiogenic shock or cardiac arrest due to acute coronary syndrome","volume":"94","author":"Sakamoto","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"2024022910043389600_oeae003-B26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s12471-017-1068-y","article-title":"Veno-arterial extracorporeal membrane oxygenation in addition to primary PCI in patients presenting with ST-elevation myocardial infarction","volume":"26","author":"Van den Brink","year":"2018","journal-title":"Neth Heart J"},{"key":"2024022910043389600_oeae003-B27","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.athoracsur.2019.04.049","article-title":"Extracorporeal life support in myocardial infarction-induced cardiogenic shock: weaning success","volume":"108","author":"Wagner","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"2024022910043389600_oeae003-B28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/00033197221091641","article-title":"Temporary mechanical circulatory support in cardiogenic shock due to ST-elevation myocardial infarction: analysis of the national readmissions database","volume":"74","author":"Briasoulis","year":"2023","journal-title":"Angiology"},{"key":"2024022910043389600_oeae003-B29","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jcrc.2015.05.022","article-title":"Long-term survival of adults with cardiogenic shock after venoarterial extracorporeal membrane oxygenation","volume":"30","author":"Burrell","year":"2015","journal-title":"J Crit Care"},{"key":"2024022910043389600_oeae003-B30","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/ejhf.260","article-title":"Clinical picture and risk prediction of short-term mortality in cardiogenic shock","volume":"17","author":"Harjola","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"2024022910043389600_oeae003-B31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1055\/s-0042-1757394","article-title":"Extracorporeal life support organisation registry report 2022","volume":"6","author":"Rycus","year":"2022","journal-title":"Journal of Cardiac Critical Care"},{"key":"2024022910043389600_oeae003-B32","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1161\/CIR.0000000000000525","article-title":"Contemporary management of cardiogenic shock: a scientific statement from the American Heart Association","volume":"136","author":"van Diepen","year":"2017","journal-title":"Circulation"},{"key":"2024022910043389600_oeae003-B33","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/S0140-6736(23)01607-0","article-title":"Venoarterial extracorporeal membrane oxygenation in patients with infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials","volume":"402","author":"Zeymer","year":"2023","journal-title":"Lancet"},{"key":"2024022910043389600_oeae003-B34","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1253\/circj.CJ-20-0259","article-title":"Optimal timing of venoarterial-extracorporeal membrane oxygenation in acute myocardial infarction patients suffering from refractory cardiogenic shock","volume":"84","author":"Choi","year":"2020","journal-title":"Circ J"},{"key":"2024022910043389600_oeae003-B35","doi-asserted-by":"crossref","first-page":"1104357","DOI":"10.3389\/fcvm.2022.1104357","article-title":"Meta-analysis of extracorporeal membrane oxygenation in combination with intra-aortic balloon pump vs. extracorporeal membrane oxygenation only in patients with cardiogenic shock due to acute myocardial infarction","volume":"9","author":"Meertens","year":"2023","journal-title":"Front Cardiovasc Med"}],"container-title":["European Heart Journal Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjopen\/advance-article-pdf\/doi\/10.1093\/ehjopen\/oeae003\/56245513\/oeae003.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjopen\/article-pdf\/4\/1\/oeae003\/56727099\/oeae003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjopen\/article-pdf\/4\/1\/oeae003\/56727099\/oeae003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T10:06:16Z","timestamp":1709201176000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjopen\/article\/doi\/10.1093\/ehjopen\/oeae003\/7576932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,29]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,12,29]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjopen\/oeae003","relation":{},"ISSN":["2752-4191"],"issn-type":[{"value":"2752-4191","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1]]},"published":{"date-parts":[[2023,12,29]]},"article-number":"oeae003"}}