{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:00:30Z","timestamp":1790362830711,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Pulsed field ablation (PFA) is a promising ablation technique for pulmonary vein isolation (PVI) with appealing advantages over radiofrequency (RF) including speed, tissue selectivity, and the promise of enhanced durability. In this study, we determine the procedural performance, efficacy, safety, and durability of PFA and compare its performance with a dataset of optimized RF ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>After propensity score matching, we compared 161 patients who received optimized RF-guided PVI in the PowerPlus study (CLOSE protocol) with 161 patients undergoing PFA-guided PVI for paroxysmal or persistent atrial fibrillation (AF; pentaspline basket catheter). The median age was 65 years with 78% paroxysmal AF in the PFA group (comparable characteristics in the RF group). Pulsed field ablation\u2013guided PVI was obtained in all patients with a procedure time of 47\u2005min (vs. 71\u2005min in RF, P &amp;lt; 0.0001) and a fluoroscopy time of 15\u2005min (vs. 11\u2005min in RF, P &amp;lt; 0.0001). One serious adverse event [transient ischaemic attack] occurred in a patient with thrombocytosis (0.6 vs. 0% in RF). During the 6-month follow-up, 24 and 27 patients experienced a recurrence with 20 and 11 repeat procedures in the PFA and the RF groups, respectively (P = 0.6 and 0.09). High-density mapping revealed a status of 4 isolated veins in 7\/20 patients in the PFA group and in 2\/11 patients in the RF group (35 vs. 18%, P = 0.3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pulsed field ablation fulfils the promise of offering a short and safe PVI procedure, even when compared with optimized RF in experienced hands. Pulmonary vein reconnection is the dominant cause of recurrence and tempers the expectation of a high durability rate with PFA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeae014","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T20:15:58Z","timestamp":1709151358000},"source":"Crossref","is-referenced-by-count":7,"title":["Procedural performance and outcome after pulsed field ablation for pulmonary vein isolation: comparison with a reference radiofrequency database"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-3693","authenticated-orcid":false,"given":"Benjamin","family":"De Becker","sequence":"first","affiliation":[{"name":"Department of Cardiology, AZ Sint-Jan Hospital , Ruddershove 10, 8000 Bruges , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9436-7820","authenticated-orcid":false,"given":"Milad","family":"El Haddad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, AZ Sint-Jan Hospital , Ruddershove 10, 8000 Bruges , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1885-7606","authenticated-orcid":false,"given":"Maarten","family":"De Smet","sequence":"additional","affiliation":[{"name":"Department of Cardiology, AZ Sint-Jan Hospital , Ruddershove 10, 8000 Bruges , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7341-5640","authenticated-orcid":false,"given":"Clara","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"Department of Cardiology, AZ Sint-Jan Hospital , Ruddershove 10, 8000 Bruges , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4575-5231","authenticated-orcid":false,"given":"Rene","family":"Tavernier","sequence":"additional","affiliation":[{"name":"Department of 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