{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:51:30Z","timestamp":1790650290070,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lennander\u2019s Foundation"},{"name":"Erik, Karin and G\u00f6sta Selander\u2019s Foundation"},{"name":"Royal Society of Arts and Scientists"},{"DOI":"10.13039\/100018853","name":"Uppsala County Association Against Heart and Lung Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018853","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Swedish Heart and Lung Association"},{"DOI":"10.13039\/501100009230","name":"Uppsala County Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009230","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u00c5ke Senning\u2019s memory"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To investigate (i) the association between pre-operative left atrial (LA) reservoir strain and post-operative atrial fibrillation (AF) and (ii) the incidence of post-operative ischaemic stroke events separately in bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) patients after surgical aortic valve replacement for isolated severe aortic stenosis (AS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We prospectively enrolled 227 patients (n = 133 BAV and n = 94 TAV) with isolated severe AS scheduled for aortic valve replacement. A comprehensive intra- and inter-observer validated pre-operative echocardiogram with an analysis of LA reservoir strain was performed. Post-operative AF was defined as a sustained (&amp;gt;30\u2005s) episode of AF or atrial flutter. The timing of neurological events was defined in accordance with the Valve Academic Research Consortium-3 criteria for stroke. Post-operative AF occurred in 114 of 227 patients (50.2%), with no difference between BAV and TAV patients (48.1 vs. 53.1%, P = 0.452). Persisting post-operative AF at discharge was more frequent in BAV patients (29.7 vs. 8.0%, P = 0.005). Pre-operative LA reservoir strain was independently associated with post-operative AF (odds ratio = 1.064, 95% confidence interval 1.032\u20131.095, P &amp;lt; 0.001), with a significant interaction between LA reservoir strain and aortic valve morphology (Pinteraction = 0.002). The cumulative transient ischemic attack (TIA)\/stroke incidence during follow-up was significantly higher in BAV patients (19.1 vs. 5.8% at 5 years).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pre-operative LA function was associated with post-operative AF after aortic valve replacement in BAV AS patients, while post-operative AF in TAV AS patients likely depends on transient post-operative alterations and traditional cardiovascular risk factors. TIA\/stroke during follow-up was more common in BAV AS patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeae020","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T19:53:07Z","timestamp":1711655587000},"source":"Crossref","is-referenced-by-count":10,"title":["Left atrial dysfunction in bicuspid aortic valve patients with severe aortic stenosis is associated with post-operative atrial fibrillation following aortic valve replacement"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3867-8568","authenticated-orcid":false,"given":"Johan O","family":"Wedin","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University Hospital, entrance 70, 1st floor , SE-751 85 Uppsala , Sweden"},{"name":"Department of Cardiothoracic Surgery, Uppsala University Hospital, entrance 50, 4th floor , SE-751 85 Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Rodin","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University Hospital, entrance 70, 1st floor , SE-751 85 Uppsala , Sweden"},{"name":"Department of Cardiothoracic Surgery, Uppsala University Hospital, entrance 50, 4th floor , SE-751 85 Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7401-278X","authenticated-orcid":false,"given":"Frank A","family":"Flachskampf","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Uppsala University Hospital , entrance 40, 5th floor, SE-751 85 Uppsala , Sweden"},{"name":"Department of Clinical Physiology, Uppsala University Hospital , entrance 40, 5th floor, SE-751 85 Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar E","family":"Simonson","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University Hospital, entrance 70, 1st floor , SE-751 85 Uppsala , Sweden"},{"name":"Department of Cardiothoracic Surgery, Uppsala University Hospital, entrance 50, 4th floor , SE-751 85 Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Pallin","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Uppsala University Hospital, entrance 50, 4th floor , SE-751 85 Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"H\u00f6rsne Malmborg","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Uppsala University Hospital, entrance 50, 4th floor , SE-751 85 Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan K","family":"James","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Uppsala University Hospital , entrance 40, 5th floor, SE-751 85 Uppsala , Sweden"},{"name":"Department of Cardiology, Uppsala University Hospital , entrance 40, 5th floor, SE-751 85 Uppsala , Sweden"},{"name":"Uppsala Clinical Research Center , Uppsala Science Park, Hubben, Dag Hammarskj\u00f6lds v\u00e4g 38, SE-751 85 Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"St\u00e5hle","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University Hospital, entrance 70, 1st floor , SE-751 85 Uppsala , Sweden"},{"name":"Department of Cardiothoracic Surgery, Uppsala University Hospital, entrance 50, 4th floor , SE-751 85 Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Henrik","family":"Grinnemo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University Hospital, entrance 70, 1st floor , SE-751 85 Uppsala , 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