{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T20:38:27Z","timestamp":1781901507705,"version":"3.54.5"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>With the 2022 pulmonary hypertension (PH) definition, the mean pulmonary artery pressure (mPAP) threshold for any PH was lowered from \u226525 to &amp;gt;20\u2005mmHg, and the pulmonary vascular resistance (PVR) value to differentiate between isolated post-capillary PH (IpcPH) and combined pre- and post-capillary PH (CpcPH) was reduced from &amp;gt;3 Wood units (WU) to &amp;gt;2 WU. We assessed the impact of this change in the PH definition in aortic stenosis (AS) patients undergoing aortic valve replacement (AVR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Severe AS patients (n = 503) undergoing pre-AVR cardiac heart catheterization were classified according to both the 2015 and 2022 definitions. The post-AVR mortality [median follow-up 1348 (interquartile range 948\u20131885) days] was assessed. According to the 2015 definition, 219 (44% of the entire population) patients had PH: 63 (29%) CpcPH, 125 (57%) IpcPH, and 31 (14%) pre-capillary PH. According to the 2022 definition, 321 (+47%) patients were diagnosed with PH, and 156 patients (31%) were re-classified: 26 patients from no PH to IpcPH, 38 from no PH to pre-capillary PH, 38 from no PH to unclassified PH, 4 from pre-capillary PH to unclassified PH, and 50 from IpcPH to CpcPH (CpcPH: +79%). With both definitions, only the CpcPH patients displayed increased mortality (hazard ratios \u2248 4). Among the PH-defining haemodynamic components, PVR was the strongest predictor of death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In severe AS, the application of the 2022 PH definition results in a substantially higher number of patients with any PH as well as CpcPH. With either definition, CpcPH patients have a significantly increased post-AVR mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjopen\/oeae037","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T16:26:57Z","timestamp":1717000017000},"source":"Crossref","is-referenced-by-count":5,"title":["Impact of the 2022 pulmonary hypertension definition on haemodynamic classification and mortality in patients with aortic stenosis undergoing valve replacement"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7036-5791","authenticated-orcid":false,"given":"Micha T","family":"Maeder","sequence":"first","affiliation":[{"name":"Department of Cardiology, Kantonsspital St. Gallen , Rorschacherstrasse 95, CH-9007 St. Gallen , Switzerland"},{"name":"Departement of Medicine, University of Basel , Klingelbergstrasse 61, CH-4056 Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kantonsspital St. Gallen , Rorschacherstrasse 95, CH-9007 St. Gallen , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Pohle","sequence":"additional","affiliation":[{"name":"Lung Center, Kantonsspital St. Gallen , Rorschacherstrasse 95, CH-9007 St. Gallen , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joannis","family":"Chronis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kantonsspital St. Gallen , Rorschacherstrasse 95, CH-9007 St. Gallen , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Baty","sequence":"additional","affiliation":[{"name":"Lung Center, Kantonsspital St. Gallen , Rorschacherstrasse 95, CH-9007 St. Gallen , 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